Assessing the Impact of Non-tailpipe Emissions From Traffic on the Asthmatic Airway

NCT05848791 | Completed

• 5 other identifiers: 32078415601955343AUK-AC-2018CR-83590201
• Study Type: observational
• Target: 52
• Locations: 1 country
• Sites: 1

Brief Summary

The goal of this observational study is to explore the health impacts of exposure to nontailpipe vehicle air pollution. The main question it aims to answer is: Does short term exposure to increased non-tailpipe course mode PM induce negative respiratory responses in adults living with asthma? We will recruit 48 non-smoking adults with mild-moderate asthma. Participants will be recruited from central and east London Participants will be exposed to three contrasting air quality environments, in field laboratories at the following locations:

1. 1.High-speed continuous traffic location, to enhance tire wear emissions
2. 2.An urban background location away from nearby traffic sources
3. 3.A busy road junction characterized by stop-go traffic to enhance emissions from brake wear

Conditions

Asthma

Outcome Measures

Primary Outcomes (1)

• Change in Forced Expiratory volume in one Second (FEV1)

  FEV1 as measured by spirometry

  0 hours and 2.5hours.

Secondary Outcomes (5)

• Change in Forced Vital Capacity (FVC)

  0 hours, 2.5hours and 26 hours

• Change in Fractional expired Nitric Oxide

  0 hours, 2.5hours and 26 hours

• Change in Daily asthma symptoms

  0 hours, 2.5hours and 26 hours

• Change in Immune response

  0 hours, 2.5hours and 26 hours

• Change in Airway resistance

  0 hours, 2.5hours and 26 hours

Interventions

Exercise exposure OTHER

Participants are exposed to three different air quality environments in central London, chosen to maximise differences in nontailpipe air pollution. Participants will cycle at 60% of estimated maximum vo2 on static bikes for six 15 minute bouts with 15 minutes rest between bouts.

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Participants will be recruited from universities and general practices in London.

You may qualify if:

• Doctor diagnosed asthma starting on or before age 16 years
• Prescribed regular inhaled corticosteroid medication
• Able to use a static exercise bicycle for the study duration

You may not qualify if:

• Tobacco smoking, or living with smoker
• Body mass index (BMI) \> 30
• Asthma hospitalisation within 12 months
• Three or more asthma episodes requiring oral corticosteroid medication within 12 months
• Other major lung disease
• Chest surgery within 6 months
• Unable to give informed consent
• Occupational exposure to particulate matter (PM) or high levels of air pollution

Sponsors & Collaborators

• Queen Mary University of London: lead
• Asthma UK: collaborator
• Health Effects Institute: collaborator
• Imperial College London: collaborator

Study Sites (1)

Queen Mary University London

London, E1 2A, United Kingdom

Location

Biospecimen

Retention: SAMPLES WITH DNA

Blood Plasma. Nasal Mucus. Urine.

MeSH Terms

Conditions

Asthma

Condition Hierarchy (Ancestors)

Bronchial Diseases; Respiratory Tract Diseases; Lung Diseases, Obstructive; Lung Diseases; Respiratory Hypersensitivity; Hypersensitivity, Immediate; Hypersensitivity; Immune System Diseases

Study Officials

• James Scales, PhD

  Queen Mary University London

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: CASE CROSSOVER
• Time Perspective: CROSS SECTIONAL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Research Fellow (AUKCAR)

Study Record Dates

• First Submitted: April 13, 2023
• First Posted: May 8, 2023
• Study Start: December 1, 2022
• Primary Completion: August 1, 2023
• Study Completion: August 1, 2023
• Last Updated: March 18, 2025

Record last verified: 2025-03

Data Sharing

• IPD Sharing: Will not share

Locations

GB (1)