Rhythmic Auditory Stimulation on Neural Activity During Finger-tapping in PD Patients

NCT05839821 | Not Yet Recruiting

• 1 other identifier: HongKongPU21037721r_20230220
• Study Type: observational
• Target: 72
• Locations: 0 countries
• Sites: N/A

Brief Summary

Introduction Bradykinesia (i.e., slow movements) is one of the most prominent symptoms of Parkinson's disease (PD) and has a negative impact on quality of life. Rhythmic auditory stimulation (RAS), a widely used and promising treatment technique, has been shown to effectively improve gait speed in PD patients. However, only few studies have explored effects and neural mechanisms of RAS on upper-limb movements. The investigators will conduct two studies to investigate effects and mechanisms of RAS on upper-limb movements in PD patients. The purpose of this study is to examine real-time neural activity when patients with PD and healthy controls listen to RAS and execute finger-tapping task simultaneously. Methods and analysis This study will recruit patients with PD and healthy controls. Electroencephalography (EEG) will be used under six conditions related to a finger-tapping task. Two-way repeated measures analysis of variance will be performed to investigate the group and condition effects on neural mechanisms. Study significance This study will offer evidence on RAS effects and mechanisms by investigating the changes in upper-limb movements and neural mechanisms during auditory-motor entrainment. Results from this study will provide a solid foundation for further research and clinical applications of RAS.

Conditions

Acoustic Stimulation; Parkinson Disease; Electroencephalography

Keywords

Acoustic Stimulation; Parkinson Disease; Movement; Electroencephalography

Outcome Measures

Primary Outcomes (2)

• The spectral power analysis of Electroencephalography (EEG)

  The spectral power analysis (unit: watt) will be conducted

  EEG will be continuously recorded during the whole experiment, which is about 20 minutes.

• The functional connectivity analysis of Electroencephalography (EEG)

  The functional connectivity analysis (unit: coherence) will be conducted

  EEG will be continuously recorded during the whole experiment, which is about 20 minutes.

Study Arms (2)

PD patients

Patients with Parkinson's disease

Behavioral: noF-noRAS; Behavioral: F-noRAS; Behavioral: noF-100RAS; Behavioral: F-100RAS; Behavioral: F-105RAS; Behavioral: F-110RAS

Healthy controls

Healthy older adults

Behavioral: noF-noRAS; Behavioral: F-noRAS; Behavioral: noF-100RAS; Behavioral: F-100RAS; Behavioral: F-105RAS; Behavioral: F-110RAS

Interventions

noF-noRAS BEHAVIORAL

resting state, that is, without finger-tapping and without listening to RAS

Healthy controls; PD patients

F-noRAS BEHAVIORAL

finger-tapping without listening to RAS

Healthy controls; PD patients

noF-100RAS BEHAVIORAL

listening to RAS with the 100% of the baseline tempo and without finger-tapping

Healthy controls; PD patients

F-100RAS BEHAVIORAL

finger-tapping and listening to RAS with 100 % of baseline tempo

Healthy controls; PD patients

F-105RAS BEHAVIORAL

finger-tapping and listening to RAS with 105 % of baseline tempo

Healthy controls; PD patients

F-110RAS BEHAVIORAL

finger-tapping and listening to RAS with 110 % of baseline tempo

Healthy controls; PD patients

Eligibility Criteria

• Age: 18 Years - 85 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Patients with Parkinson's disease

You may qualify if:

• (a) idiopathic PD diagnosed by a neurologist based on the Movement Disorders Society clinical diagnostic criteria;
• (b) the Hoehn and Yahr stage is 2 or 3, meaning that bilateral movement problems or combination with mild postural instability;
• (c) a score of Montreal Cognitive Assessment (MoCA) is equal to or higher than 21 to ensure that they understand experimental instructions;
• (d) a score of Edinburgh Handedness Inventory is above 60 to ensure that they are right-handed;
• (e) types and doses of medications remain unchanged in the past month right before participation.
• Age- and sex-matched healthy controls who filled the criteria (c) and (d) will be recruited from communities.

You may not qualify if:

• the presence of medical conditions or diseases that may affect hand movements, vision, or hearing based on self-report.

Sponsors & Collaborators

• The Hong Kong Polytechnic University: lead

Related Publications (6)

• Fan W, Li J, Wei W, Xiao SH, Liao ZJ, Wang SM, Fong KNK. Effects of rhythmic auditory stimulation on upper-limb movements in patients with Parkinson's disease. Parkinsonism Relat Disord. 2022 Aug;101:27-30. doi: 10.1016/j.parkreldis.2022.06.020. Epub 2022 Jun 23.

  PMID: 35763906 BACKGROUND

• Wang SM, Chan ST, Wong YL, Hsu HM, Lee CY, Check CY, Leung CK. Rhythmic auditory stimulation incorporated in training improved movements in individuals with psychotic-like experiences. Eur Arch Psychiatry Clin Neurosci. 2023 Jun;273(4):995-1005. doi: 10.1007/s00406-022-01524-3. Epub 2022 Nov 24.

  PMID: 36422679 BACKGROUND

• Leuk JSP, Low LLN, Teo WP. An Overview of Acoustic-Based Interventions to Improve Motor Symptoms in Parkinson's Disease. Front Aging Neurosci. 2020 Aug 14;12:243. doi: 10.3389/fnagi.2020.00243. eCollection 2020.

  PMID: 32922283 BACKGROUND

• Thaut MH, McIntosh GC, Rice RR, Miller RA, Rathbun J, Brault JM. Rhythmic auditory stimulation in gait training for Parkinson's disease patients. Mov Disord. 1996 Mar;11(2):193-200. doi: 10.1002/mds.870110213.

  PMID: 8684391 BACKGROUND

• Koshimori Y, Thaut MH. Future perspectives on neural mechanisms underlying rhythm and music based neurorehabilitation in Parkinson's disease. Ageing Res Rev. 2018 Nov;47:133-139. doi: 10.1016/j.arr.2018.07.001. Epub 2018 Jul 10.

  PMID: 30005957 BACKGROUND

• Dong VA, Fong KN, Chen YF, Tseng SS, Wong LM. 'Remind-to-move' treatment versus constraint-induced movement therapy for children with hemiplegic cerebral palsy: a randomized controlled trial. Dev Med Child Neurol. 2017 Feb;59(2):160-167. doi: 10.1111/dmcn.13216. Epub 2016 Aug 9.

  PMID: 27503605 BACKGROUND

MeSH Terms

Conditions

Parkinson Disease

Condition Hierarchy (Ancestors)

Parkinsonian Disorders; Basal Ganglia Diseases; Brain Diseases; Central Nervous System Diseases; Nervous System Diseases; Movement Disorders; Synucleinopathies; Neurodegenerative Diseases

Study Officials

• Wei FAN (PhD student), MSc

  Rehabilitation Sciences

  PRINCIPAL INVESTIGATOR

Central Study Contacts

Wei FAN (PhD student), MSc

CONTACT

+85267681229; 21037721r@connect.polyu.hk

Shu-mei Wang (supervisor), PhD

CONTACT

+85227664197; shumei.wang@polyu.edu.hk

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: CROSS SECTIONAL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: PhD Candidate

Study Record Dates

• First Submitted: February 24, 2023
• First Posted: May 3, 2023
• Study Start: June 1, 2023
• Primary Completion: March 31, 2026
• Study Completion: March 31, 2026
• Last Updated: May 3, 2023

Record last verified: 2023-04

Data Sharing

• IPD Sharing: Will not share