Auditory and Vestibular Function in Parkinson's Disease

NCT05034094 | Unknown

• 1 other identifier: parkinson
• Study Type: observational
• Target: 70
• Locations: 0 countries
• Sites: N/A

Brief Summary

The aims of this study are to:

1. 1.Evaluate peripheral and central auditory and vestibular function in group of adults with idiopathic PD.
2. 2.Determine the relationship between the presence of significant auditory and vestibular dysfunctions to patients' demographic, clinical (motor and non-motor manifestations) and treatment variables

Conditions

Parkinson Disease

Outcome Measures

Primary Outcomes (1)

• Auditory and vestibular functions in patients with Parkinson's disease

  1.1 basic audiological evaluation this include otoscopic examination , screening audiogram,stapedial reflex testing 1.2 vestibular evaluation by VNG recording ,VEMP recording ,cVEMP recording ,oVEMP recording

  16 month

Interventions

VEMP recording OTHER

* Clinical evaluation: All participants will undergo detailed medical and neurological histories and examinations. * The severity of manifestations of PD will be assessed using the Movement Disorder Society (MDS)-sponsored new version of Unified PD Rating Scale (MDS-UPDRS).

Eligibility Criteria

• Age: 55 Years - 70 Years
• Gender Eligibility Details: old age
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

* Patients with PD will be recruited from the Department of Neurology and Psychiatry and its out-patient clinic, Assiut University Hospital, Assiut, Egypt. * All patients will be encoded to confidentiality.

You may qualify if:

• Adults with age range 55-65 years old from both gender.
• Patients have to fulfil the criteria for diagnosis of idiopathic PD \[Postuma et al., 2015\]. and age, sex and socioeconomic matched healthy subjects recruited from the general population as controls for statistical comparisons.

You may not qualify if:

• \- Concomitant medical and metabolic illnesses.
• Secondary or atypical parkinsonism
• Evidence of concomitant cerebrovascular stroke temporally related to the onset of the disease.
• Major psychiatric disorder known to affect cognition.
• Dementia (i.e. mini mental score examination or MMSE score \<24)
• Major language disturbance
• MRI brain showing structural lesion
• Severe known auditory (hearing thresholds \>50 dBnHL) or visual impairment affecting their ability to complete testing before participation of the study.
• Improper neck movements that interfere with assessment.
• Middle ear diseases, ear infection, ear trauma, or acoustic trauma

Sponsors & Collaborators

• Assiut University: lead

Related Publications (2)

• Smith PF. Vestibular Functions and Parkinson's Disease. Front Neurol. 2018 Dec 11;9:1085. doi: 10.3389/fneur.2018.01085. eCollection 2018.

  PMID: 30619045 BACKGROUND

• Scarpa A, Cassandro C, Vitale C, Ralli M, Policastro A, Barone P, Cassandro E, Pellecchia MT. A comparison of auditory and vestibular dysfunction in Parkinson's disease and Multiple System Atrophy. Parkinsonism Relat Disord. 2020 Feb;71:51-57. doi: 10.1016/j.parkreldis.2020.01.018. Epub 2020 Jan 30.

  PMID: 32032926 BACKGROUND

MeSH Terms

Conditions

Parkinson Disease

Condition Hierarchy (Ancestors)

Parkinsonian Disorders; Basal Ganglia Diseases; Brain Diseases; Central Nervous System Diseases; Nervous System Diseases; Movement Disorders; Synucleinopathies; Neurodegenerative Diseases

Central Study Contacts

Mohamed kamal, master

CONTACT

01010110373; bdewimo@gmail.com

sherifa hamed, professor

CONTACT

01115324560; hamed_sherifa@yaho.com

Study Design

• Study Type: observational
• Observational Model: CASE CONTROL
• Time Perspective: RETROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: resident

Study Record Dates

• First Submitted: August 9, 2021
• First Posted: September 5, 2021
• Study Start: August 13, 2023
• Primary Completion: December 1, 2023
• Study Completion: April 1, 2024
• Last Updated: September 5, 2021

Record last verified: 2021-08