Knee Pressure Stimuli on Quadriceps Strength in Knee Osteoarthritis
Effects of Joint Pressure Stimuli on Quadriceps Strength and Neuromuscular Activity in Patients With Knee Ostearthritis
1 other identifier
observational
50
0 countries
N/A
Brief Summary
The study aims at investigating the effects of a periarticular knee pressure stimulation on quadriceps strength and neuromuscular activity in subjects with knee ostearthritis. Twenty-five patients with end-stage knee osteoarthritis and and twenty-five age-matched healthy subjects will be enrolled. All participants will be asked to performed isometric maximal voluntary knee extension tasks with three different pressure stimuli in terms of intensity (0 mmHg, 60 mmHg, 120 mmHg) around the knee using a sphygmomanometer. Peak force and root-mean-square peak of rectus femoris, vastus medialis, and vastus lateralis will be collected.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P25-P50 for all trials
Started Apr 2023
Shorter than P25 for all trials
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
First Submitted
Initial submission to the registry
April 7, 2023
CompletedStudy Start
First participant enrolled
April 15, 2023
CompletedFirst Posted
Study publicly available on registry
April 24, 2023
CompletedPrimary Completion
Last participant's last visit for primary outcome
June 1, 2023
CompletedStudy Completion
Last participant's last visit for all outcomes
September 1, 2023
CompletedApril 24, 2023
April 1, 2023
2 months
April 7, 2023
April 20, 2023
Conditions
Outcome Measures
Primary Outcomes (1)
Changes in Peak Force
Changes in strength during a maximal voluntary contraction using 0mmHg, 60mmHg or 120mmHg of compression intensity.
Baseline (0mmHg), 3 minute after baseline (60mmHg) and 6 minutes after baseline (120mmHg)
Secondary Outcomes (1)
Changes in Root Mean Square peak
Baseline (0mmHg), 3 minute after baseline (60mmHg) and 6 minutes after baseline (120mmHg)
Study Arms (2)
Patients with knee osteoarthritis
Periarticular knee compression using a sphygmomanometer.
Healthy subjects
Periarticular knee compression using a sphygmomanometer.
Interventions
Periarticular knee compression using a sphygmomanometer.
Eligibility Criteria
Subjects with end-stage knee osteoarthritis with the aforementioned eligibility criteria and age-matched healthy subjects with the same criteria except "end-stage knee osteoarthritis".
You may qualify if:
- End-stage knee osteoarthritis
- Age between 40 and 80 years
- at least 0-90° of knee range of motion along the sagittal plane
You may not qualify if:
- Cognitive impairments or psychiatric disorders
- Concomitant neurological, orthopedic, cardiovascular disorders
- Lower limb orthopedic surgery or traumatic events in the previous year
Contact the study team to confirm eligibility.
Sponsors & Collaborators
MeSH Terms
Conditions
Condition Hierarchy (Ancestors)
Study Design
- Study Type
- observational
- Observational Model
- COHORT
- Time Perspective
- CROSS SECTIONAL
- Sponsor Type
- OTHER
- Responsible Party
- SPONSOR
Study Record Dates
First Submitted
April 7, 2023
First Posted
April 24, 2023
Study Start
April 15, 2023
Primary Completion
June 1, 2023
Study Completion
September 1, 2023
Last Updated
April 24, 2023
Record last verified: 2023-04
Data Sharing
- IPD Sharing
- Will not share