Muscle Architecture in Knee Osteoarthritis

NCT06319937 | Not Yet Recruiting

• 1 other identifier: OA2023
• Study Type: interventional
• Target: 50
• Locations: 0 countries
• Sites: N/A

Brief Summary

Background: The aim of this study was to compare the knee and ankle muscle architecture and plantar pressure distribution differences in knee osteoarthritis (OA) women with healthy women. Methods: Fifty women with knee OA (Mean age=52.11±4.96 years, mean BMI=30.94±4.23 kg/m2) and fifty healthy women (Mean age= 50.93±3.78 years, mean BMI=29.06±4.82 kg/m2) were included in the study. Ultrasonography was used to evaluate Rectus Femoris (RF), Vastus Medialis (VM), Vastus Lateralis (VL), Peroneus Longus (PL), Tibialis Anterior (TA), and Medial Gastrocnemius (MG) muscle thickness, pennation angle, fascicle length, and fat thickness. The plantar pressure distribution was evaluated using the Digital Biometry Scanning System and software (DIASU, Italy).

Conditions

Knee Osteoarthritis; Foot Deformities; Muscle Weakness; Kinesiophobia

Keywords

knee osteoarthritis; ultrasonography; kinesiophobia; functional performance; muscles; foot

Outcome Measures

Primary Outcomes (3)

• Muscle thickness

  Muscle thickness of Rectus Femoris, Vastus Medialis, Vastus Lateralis, Medial Gastrocnemius, Peronalis Longus. Muscle thickness of Rectus Femoris, Vastus Medialis, Vastus Lateralis, Medial Gastrocnemius, Peronalis Longus. Ultrasound, which is a measurement method with validity and reliability in individuals with knee OA, was used to evaluate the knee and ankle muscles. A total of six muscles were evaluated, including three knee muscles and three ankle muscles: Rectus Femoris (RF), Vastus Medialis (VM), Vastus Lateralis (VL), Tibialis Anterior (TA), Peroneus Longus (PL) and Medial Gastrocnemius (MG). The muscle thickness of each muscle were evaluated using B-Mode ultrasonography (Esaote MyLab X8 eXP Ultrasound System, Florence, Italy) and a linear array transducer (4-11.4 MHz)

  15 days

• Pennation angle

  Pennation angle of Rectus Femoris, Vastus Medialis, Vastus Lateralis, Medial Gastrocnemius, Peronalis Longus. Ultrasound, which is a measurement method with validity and reliability in individuals with knee OA, was used to evaluate the knee and ankle muscles. A total of six muscles were evaluated, including three knee muscles and three ankle muscles: Rectus Femoris (RF), Vastus Medialis (VM), Vastus Lateralis (VL), Tibialis Anterior (TA), Peroneus Longus (PL) and Medial Gastrocnemius (MG). The pennation angle of each muscle were evaluated using B-Mode ultrasonography (Esaote MyLab X8 eXP Ultrasound System, Florence, Italy) and a linear array transducer (4-11.4 MHz)

  15 days

• Fat thickness

  Fat thickness of Rectus Femoris, Vastus Medialis, Vastus Lateralis, Medial Gastrocnemius, Peronalis Longus. Ultrasound, which is a measurement method with validity and reliability in individuals with knee OA, was used to evaluate the knee and ankle muscles. A total of six muscles were evaluated, including three knee muscles and three ankle muscles: Rectus Femoris (RF), Vastus Medialis (VM), Vastus Lateralis (VL), Tibialis Anterior (TA), Peroneus Longus (PL) and Medial Gastrocnemius (MG). The fat thickness of each muscle were evaluated using B-Mode ultrasonography (Esaote MyLab X8 eXP Ultrasound System, Florence, Italy) and a linear array transducer (4-11.4 MHz)

  15 days

Secondary Outcomes (2)

• Stair climbing test

  15 days

• Sit-stand test

  15 days

Study Arms (1)

OA Group

EXPERIMENTAL

Knee OA were included in the study. All patients exhibited evident radiographic changes in either unilateral or bilateral knees, consistent with a diagnosis of osteoarthritis, and were classified as Kellgren Lawrence (K-L) grade 2.

Diagnostic Test: Ultrasound

Interventions

Ultrasound DIAGNOSTIC_TEST

Ultrasound

OA Group

Eligibility Criteria

• Age: 45 Years - 65 Years
• Sex: female
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Aged 45-65 years
• Activity-related knee pain
• Morning knee stiffness for 30 min
• Knee pain on most days for 3 months or more

You may not qualify if:

• Having lower extremity surgery
• Conditions that cause congenital or developmental diseases
• The presence of systemic inflammatory arthritis
• Polyneuropathy/lower extremity neuropathy, severe radiculopathy
• Having undergone physical therapy, exercises or knee injections for the knee in the previous 6 months
• Congenital foot deformity
• BMI higher than 35 kg/m2

Sponsors & Collaborators

• Hacettepe University: lead

MeSH Terms

Conditions

Osteoarthritis, Knee; Foot Deformities; Muscle Weakness; Kinesiophobia

Interventions

Ultrasonography

Condition Hierarchy (Ancestors)

Osteoarthritis; Arthritis; Joint Diseases; Musculoskeletal Diseases; Rheumatic Diseases; Muscular Diseases; Neuromuscular Manifestations; Neurologic Manifestations; Nervous System Diseases; Pathologic Processes; Pathological Conditions, Signs and Symptoms; Signs and Symptoms; Phobic Disorders; Anxiety Disorders; Mental Disorders

Intervention Hierarchy (Ancestors)

Diagnostic Imaging; Diagnostic Techniques and Procedures; Diagnosis

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NA
• Masking: NONE
• Purpose: DIAGNOSTIC
• Intervention Model: SINGLE GROUP
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: PT, PhD, Prof.

Study Record Dates

• First Submitted: January 26, 2024
• First Posted: March 20, 2024
• Study Start: April 1, 2024
• Primary Completion: June 1, 2024
• Study Completion: September 1, 2025
• Last Updated: March 20, 2024

Record last verified: 2024-03