Human Phenotype Project Study Protocol
Longitudinal Collection of Observational Clinical and Lifestyle Data
1 other identifier
observational
30,000
1 country
1
Brief Summary
This is a prospective study aimed at recruiting 30,000 individuals, aged 40-70 years old, and following them longitudinally for 25 years with repeated measurements. The basic follow-up frame will include a visit to the Clinical Test Center (CTC) every two years and a phone interview every other year (on uneven years). Sample collection and biobanking will be performed every two years and online questionnaires will be filled out on an annual basis. The primary goals are to study the variation observed across different individuals in disease susceptibility, clinical phenotypes, and therapeutic responses. The study aims at studying the complex interplay and relative contribution of different omics, physiological characteristics and lifestyle on disease pathogenesis and progression and to evaluate how these effects are mediated.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P75+ for all trials
Started Oct 2018
Longer than P75 for all trials
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
Click on a node to explore related trials.
Study Timeline
Key milestones and dates
Study Start
First participant enrolled
October 1, 2018
CompletedFirst Submitted
Initial submission to the registry
January 31, 2023
CompletedFirst Posted
Study publicly available on registry
April 18, 2023
CompletedPrimary Completion
Last participant's last visit for primary outcome
December 31, 2045
ExpectedStudy Completion
Last participant's last visit for all outcomes
December 31, 2045
July 16, 2024
July 1, 2024
27.3 years
January 31, 2023
July 14, 2024
Conditions
Outcome Measures
Primary Outcomes (1)
Adult disease
Development of medical conditions based on participant's self-reporting coded to ICD11.
25 years
Eligibility Criteria
General volunteering population who can freely register for the study.
You may qualify if:
- Ages 18+, males and females.
You may not qualify if:
- Pregnancy.
- Mentally disabled or in general legally non-competent.
- Prisoner or soldier. Soldiers: mandatory service only
- Active cancer
- Fertility Treatments (current)
- Hepatitis ( B, C), chronic or acute
- HIV
- Liver cirrhosis
- Dialysis
- Unstable medical conditions
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Study Sites (1)
Weizmann institute of science
Rehovot, Israel
Related Publications (1)
Rein M, Elkan M, Godneva A, Dolev NC, Segal E. Sex-specific dietary habits and their association with weight change in healthy adults. BMC Med. 2024 Nov 6;22(1):512. doi: 10.1186/s12916-024-03730-3.
PMID: 39501340DERIVED
Biospecimen
Blood and stool sampls
MeSH Terms
Conditions
Condition Hierarchy (Ancestors)
Central Study Contacts
Study Design
- Study Type
- observational
- Observational Model
- COHORT
- Time Perspective
- PROSPECTIVE
- Sponsor Type
- OTHER
- Responsible Party
- PRINCIPAL INVESTIGATOR
- PI Title
- Prof. Eran Segal, PI at the department of computer science and applied math
Study Record Dates
First Submitted
January 31, 2023
First Posted
April 18, 2023
Study Start
October 1, 2018
Primary Completion (Estimated)
December 31, 2045
Study Completion (Estimated)
December 31, 2045
Last Updated
July 16, 2024
Record last verified: 2024-07