Arterial Blood Gases in Weaning of Mechanical VEntilation

NCT05801692 | Unknown

• 1 other identifier: CHUB WAVE
• Study Type: observational
• Target: 100
• Locations: 1 country
• Sites: 1

Brief Summary

Weaning of mechanical ventilation is an important phase of ICU (Intensive Care Unit) patient hospitalization. Patients have to pass a spontaneous breathing trial, can have a phase of pause with mechanical ventilation before extubation and then can be weaned of invasive mechanical ventilation. Spontaneous breathing trial can be performed with a T-Tube or with Pressure support without PEEP (End Expiratory Positive Pressure) . Duration of spontaneous breathing trial range from 30 minutes to 120 minutes. Some clinicians performed an arterial blood gases at the end of the spontaneous breathing trial but this practice is not really defined and clearly explained in recommendations. Patients can benefit of ventilation support after extubation like non invasive pressure support or high flow nasal canulae. The procedure can be very different from a center to another, especially for arterial blood gases at the end of spontaneous breathing trial. Our aim is to observe in a multicenter study the daily practice of weaning of mechanical ventilation especially for arterial blood gases.

Conditions

Weaning of Mechanical Ventilation

Outcome Measures

Primary Outcomes (1)

• Type of spontaneous breathing trial performed

  Spontaneous breathing trial is performed either with pressure support or with a T-Piece

  In the 24 hours of spontaneous breathing trial

Secondary Outcomes (9)

• Arterial blood gases at the end of spontaneous breathing trial

  In the hour of spontaneous breathing trial

• Duration of spontaneous breathing trial

  The day of the spontaneous breathing trial

• Ventilatory procedure at the end of spontaneous breathing trial: either immediate extubation or pressure support ventilation with intubation

  The day of extubation if extubation performed

• Frequency and type of ventilatory support after extubation

  The day of extubation if extubation performed

• Need for reintubation

  During the seven days following extubation

Interventions

Weaning of mechanical ventilation PROCEDURE

Weaning of mechanical ventilation is the time when the patient is ready for separation from ventilatory support until breathing without invasive support

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Patients hospitalized in intensive care unit with invasive mechanical ventilation, first attempt of weaning of mechnical ventilation

You may qualify if:

• Older than 18 years
• first attempt of weaning of mechanical ventilation

You may not qualify if:

• withholding of life sustaining therapies
• spontaneous breathing trial unsuccessful

Sponsors & Collaborators

• Centre Hospitalier Universitaire de Besancon: lead

Study Sites (1)

BARROT

Besançon, 25320, France

Location

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: February 10, 2023
• First Posted: April 6, 2023
• Study Start: December 21, 2022
• Primary Completion: July 1, 2023
• Study Completion: October 1, 2023
• Last Updated: April 6, 2023

Record last verified: 2023-01

Data Sharing

• IPD Sharing: Will not share

Locations

FR (1)