PPI in Weaning Prediction

NCT07120672 | Recruiting DMC

• 1 other identifier: Gaziosmanpaşa TREH, VD
• Study Type: observational
• Target: 100
• Locations: 1 country
• Sites: 1

Brief Summary

The aim of this study is to evaluate the predictive role of the Peripheral Perfusion Index (PPI) in forecasting extubation success during the weaning process in intensive care unit (ICU) patients. The study will investigate the ability of PPI to predict extubation failure by comparing it with traditional weaning criteria, including the Rapid Shallow Breathing Index (RSBI), PaO₂/FiO₂ ratio, and respiratory rate.

Conditions

Perfusion Index; Weaning of Mechanical Ventilation; ICU

Keywords

perfusion index; weaning; ıcu

Outcome Measures

Primary Outcomes (1)

• • The ability of Peripheric Perfusion Index(PPI) measured 1 hour after extubation to predict extubation failure within 48 hours following extubation.

  48 hours

Secondary Outcomes (3)

• • The predictive power of Peripheric Perfusion Index(PPI) measured at the beginning of the spontaneous breathing trial (SBT), at the 15th minute, at the end of SBT, and 2 hours after extubation in determining extubation success.

  3 hours

• • Correlation of Peripheric Perfusion Index(PPI) measurements between cardiac patients(Patients with at least one diagnosis of cardiac disease) and non-cardiac patients.

  48 hours

• Changes in Peripheric Perfusion Index(PPI) values in patients who experience spontaneous breathing trial(SBT) failure.

  48 hours

Interventions

patients were monitored for reentubation for 48 hours. OTHER

patients were monitored for reentubation for 48 hours.

weaning group OTHER

patients were monitored for reentubation for 48 hours.

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Probability Sample

Study Population

Patients who have been on mechanical ventilation for at least 48 hours and Patients over 18 years of age who are planned to undergo extubation following a spontaneous breathing trial (SBT) Patients or their legal representatives who provide informed consent to participate in the study

You may qualify if:

• Patients who have been on mechanical ventilation for at least 48 hours
• Patients over 18 years of age who are planned to undergo extubation following a spontaneous breathing trial (SBT)
• Patients or their legal representatives who provide informed consent to participate in the study

You may not qualify if:

• Patients for whom extubation is not planned due to hemodynamic instability
• Patients with peripheral vascular disease or a history of hand surgery
• Patients who die or cannot be followed up during the study period

Sponsors & Collaborators

• Gaziosmanpasa Research and Education Hospital: lead

Study Sites (1)

Gaziosmanpaşa Training and Research Hospital

Istanbul, 34000, Turkey (Türkiye)

RECRUITING

Central Study Contacts

Veysel Dinç

CONTACT

+90 545 745 3472; drvdinc@gmail.com

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER GOV
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Assist. Prof.

Study Record Dates

• First Submitted: May 7, 2025
• First Posted: August 13, 2025
• Study Start: May 8, 2025
• Primary Completion: August 15, 2025
• Study Completion: August 30, 2025
• Last Updated: August 13, 2025

Record last verified: 2025-08

Data Sharing

• IPD Sharing: Will not share

Locations

TU (1)