Environmental Mixtures, Cognitive Control and Reward Processes, and Risk for Psychiatric Problems in Adolescence

NCT05795452 | Active Not Recruiting

• 3 other identifiers: AAAU94735R01ES032296-038191
• Study Type: observational
• Target: 250
• Locations: 1 country
• Sites: 1

Brief Summary

This study aims to examine the cognitive and neural pathways underlying the joint impact of chemical and social exposures on two aspects of cognitive function: cognitive control and reward processing. The investigators will use high resolution, multi-band resting state and task functional magnetic resonance imaging (fMRI) as well as neuromelanin stain MRI to identify pathways through which exposure to a mixture of prenatal chemical and early life social exposures alters brain function and behavior. Specifically, the investigators will leverage extant prenatal exposure data (N=550) from the Columbia Center for Children's Environmental Health (CCCEH) Mothers and Newborns (MN) birth cohort and study symptoms and brain function in adolescence.

Conditions

Psychiatric Problem

Keywords

Functional magnetic resonance imaging (fMRI); Cognitive function; Cognitive Control; Reward Processing

Outcome Measures

Primary Outcomes (1)

• Youth Self Report (YSR) from the Child Behavior Checklist (CBCL)

  This is a 112-question scale for adolescents about their own behavioral functioning. It has a Likert-like scoring format and multiple syndrome and DSM-oriented scales, with higher scores indicating more symptoms. Raw scores are converted to T scores with a mean of 50 and standard deviation of 10. The range is 0 to 90.

  15 minutes during study visit

Study Arms (1)

Adolescents from the Mothers and Newborns Cohort

Eligibility Criteria

• Age: 13 Years - 20 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Child (0-17), Adult (18-64)
• Sampling Method: Non-Probability Sample

Study Population

The current proposed study is funded to conduct resting state and task fMRI and assessment of psychiatric symptoms in 250 adolescents in the Mothers and Newborns birth cohort. Prenatal exposure data will be leveraged from the CCCEH database.

You may qualify if:

• Adolescents between 13-20 years
• Available prenatal exposure data
• Adolescents and parents are English- or Spanish-speaking

You may not qualify if:

• Presence of metallic device or dental braces
• Full Scale Intelligence Quotient (IQ) \< 70 at prior assessment
• Pregnant women or lactating women

Sponsors & Collaborators

• Ohio State University: lead
• National Institute of Environmental Health Sciences (NIEHS): collaborator

Study Sites (1)

Columbia University Irving Medical Center

New York, New York, 10032, United States

Location

Study Officials

• Amy Margolis, PhD

  Ohio State University

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: March 21, 2023
• First Posted: April 3, 2023
• Study Start: February 20, 2022
• Primary Completion: May 1, 2026
• Study Completion: May 1, 2026
• Last Updated: February 25, 2026

Record last verified: 2026-02

Locations

US (1)