Novel Biomarkers in Patients With Acute Myocardial Infarction
CLEAR-AMI
Clinical, Laboratory and Echocardiographic Assessment of Biomarkers in Patients With Acute Myocardial Infarction
1 other identifier
observational
500
1 country
2
Brief Summary
This study seeks to investigate the clinical value of novel biomarkers and echocardiographic indices, including myocardial work parameters, in patients with first acute myocardial infarction. The relationship between novel echocardiographic indices with clinical data, biochemical data in different myocardial infarction types will be attempted. Prognostic implications of those indices will be explored.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P75+ for all trials
Started Mar 2022
Typical duration for all trials
2 active sites
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
Study Start
First participant enrolled
March 10, 2022
CompletedFirst Submitted
Initial submission to the registry
March 18, 2023
CompletedFirst Posted
Study publicly available on registry
March 30, 2023
CompletedPrimary Completion
Last participant's last visit for primary outcome
December 10, 2024
CompletedStudy Completion
Last participant's last visit for all outcomes
February 1, 2025
CompletedFebruary 28, 2024
February 1, 2024
2.8 years
March 18, 2023
February 25, 2024
Conditions
Keywords
Outcome Measures
Primary Outcomes (2)
Relationship between clinical, laboratory and echocardiographic biomarkers
Clinical, laboratory, conventional and novel echocardiographic parameters including among others left ventricular myocardial work indices, right ventricular myocardial work indices, 2-dimensional speckle-tracking analysis of all cardiac chambers.
24 months
Relationship between clinical, laboratory, and echocardiographic biomarkers with short- and long-term prognosis of patients
Clinical, laboratory, and echocardiographic parameters including among others left ventricular myocardial work indices, right ventricular myocardial work indices, 2-dimensional speckle-tracking analysis of all cardiac chambers. Different units of measure in this outcome do not represent different outcome measures. All clinical, laboratory and echocardiographic measurements will be evaluated separately in their own unit of measurement to assess potential prognostic biomarkers in patients with acute myocardial infarction. This does not render the measurement of each parameter a different clinical outcome.
24 months
Secondary Outcomes (5)
All-cause mortality
24 months
Cardiovascular mortality
24 months
Heart Failure hospitalization
24 months
Acute Coronary syndrome
24 months
MACE
24 months
Eligibility Criteria
This study will enroll consecutive patients admitted to the First Department of Cardiology of AHEPA University General Hospital, Aristotle University of Thessaloniki, Thessaloniki, Greece with first Acute Myocardial Infarction with or without ST elevation, as defined by the Fourth Universal Definition of Myocardial Infarction.
You may qualify if:
- Patients older than 18 years
- Patients acutely admitted at the Department of Cardiology of AHEPA University General Hospital, Thessaloniki, Greece with Acute Myocardial Infarction, as those are defined by the Fourth Universal Definition of Myocardial Infarction.
- Patients without known history of coronary artery disease
You may not qualify if:
- Patients \< 18 years old at time of coronary angiography
- Patients with a previous history of coronary artery disease and/or prior revascularization
- Inability or refusal to provide informed consent
- Subject is pregnant and/or breastfeeding or intends to become pregnant during the study
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Study Sites (2)
AHEPA University Hospital, Thessaloniki, Greece
Thessaloniki, Central Macedonia, 54621, Greece
AHEPA University Hospital, Thessaloniki, Greece
Thessaloniki, Central Macedonia, 54621, Greece
Related Publications (1)
Daios S, Anastasiou V, Moysidis DV, Didagelos M, Papazoglou AS, Stalikas N, Zegkos T, Karagiannidis E, Skoura L, Kaiafa G, Makedou K, Ziakas A, Savopoulos C, Kamperidis V. Prognostic Implications of Clinical, Laboratory and Echocardiographic Biomarkers in Patients with Acute Myocardial Infarction-Rationale and Design of the ''CLEAR-AMI Study''. J Clin Med. 2023 Sep 2;12(17):5726. doi: 10.3390/jcm12175726.
PMID: 37685793DERIVED
MeSH Terms
Conditions
Condition Hierarchy (Ancestors)
Study Officials
- STUDY DIRECTOR
Antonios Ziakas, MD, PhD
School of Medicine, Aristotle University of Thessaloniki
- STUDY CHAIR
Christos Savopoulos, MD, PhD
School of Medicine, Aristotle University of Thessaloniki
- PRINCIPAL INVESTIGATOR
Vasileios Kamperidis, MD, MSc, PhD
School of Medicine, Aristotle University of Thessaloniki
Central Study Contacts
Study Design
- Study Type
- observational
- Observational Model
- COHORT
- Time Perspective
- PROSPECTIVE
- Target Duration
- 24 Months
- Sponsor Type
- OTHER
- Responsible Party
- SPONSOR
Study Record Dates
First Submitted
March 18, 2023
First Posted
March 30, 2023
Study Start
March 10, 2022
Primary Completion
December 10, 2024
Study Completion
February 1, 2025
Last Updated
February 28, 2024
Record last verified: 2024-02