Effect of Neurodynamic Mobilization on Median Nerve Conduction Velocity in Carpal Tunnel Syndrome

NCT05788471 | Unknown DMC

• 1 other identifier: Raghda Ahmed_PhD
• Study Type: interventional
• Target: 40
• Locations: 1 country
• Sites: 1

Brief Summary

The purpose of this study is to examine:

1. 1.The effect of neurodynamic mobilization on the sensory and motor median nerve conduction velocity in carpal tunnel syndrome.
2. 2.The effect of neurodynamic mobilization on the wrist pain in carpal tunnel syndrome.
3. 3.The effect of neurodynamic mobilization on the hand function in carpal tunnel syndrome.

Conditions

Median Nerve Entrapment; Carpal Tunnel Syndrome

Outcome Measures

Primary Outcomes (3)

• Assessing the change in nerve conduction velocity of the median nerve.

  By using Electromyography apparatus measuring nerve conduction velocity of the median nerve. (motor and sensory in m/s)

  at baseline and after 4 weeks of intervention

• Assessing the change in wrist joint pain

  By using Pressure pain threshold (PPT) is defined as the minimal amount of pressure that produces pain. A simple handheld pressure algometer (PA) with a spring is commonly used, although more sophisticated electrical devices with a strain or pneumatic pressure gauge have been developed. They hold the peak force or pressure (kp (kilopond) = 10 N, Newton = 100 kPa (kilopascal)) until tared, and some may also be connected to a computer and thus have continuous output. PPT measured with a probe 1.6 mm in diameter or larger reflects the tenderness of deep tissues as anesthesia of skin only affects the results of smaller probes.

  at baseline and after 4 weeks of intervention

• Assessing the change in functional activity of the hand

  By using Modified DASH questionnaire will be used for functional activity of the hand. The Disabilities of the Arm, Shoulder and Hand (DASH) questionnaire is a 30-item questionnaire that looks at the ability of a patient to perform certain upper extremity activities. This questionnaire is a self-report questionnaire that patients can rate difficulty and interference with daily life on a 5 point Likert scale. The QuickDASH tool uses a 5-point Likert scale from which the patient can select an appropriate number corresponding to his/her severity/function level.

  at baseline and after 4 weeks of intervention

Study Arms (2)

Conventional treatment group

ACTIVE COMPARATOR

Twenty patients will receive conventional treatment in the form of superficial heat, ultrasound with freq of 1 MHz, pulsed mode 1:4 for 5 min and stretching exercise to lumbrical muscles of the hand.

Other: conventional Treatment

Neurodynamic mobilization therapy group

EXPERIMENTAL

Twenty patients will receive neurodynamic mobilization therapy (upper limb tension test 1) in addition to conventional treatment.

Other: conventional Treatment; Other: Neurodynamic mobilization

Interventions

conventional Treatment OTHER

It consists of Superficial heat, Ultrasound therapy and stretching exercise to lumbrical muscles of the hand.

Conventional treatment group; Neurodynamic mobilization therapy group

Neurodynamic mobilization OTHER

It is the mobilisation of the nervous system as an approach to physical treatment of pain. The treatment and or assessment relies on influencing pain physiology via the mechanical treatment of neural tissues and non-neural structures surrounding the nervous system.

Neurodynamic mobilization therapy group

Eligibility Criteria

• Age: 20 Years - 50 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)

You may qualify if:

• Forty carpal tunnel syndrome patients.
• All participants referred from a physician.
• Their ages range from 20-50 years old.
• Both genders will participate in the study.
• Their BMI ranges between 18.5-24.9kg/m2.
• All participants have carpal tunnel syndrome at least in one hand.
• All participants suffering from mild to moderate carpal tunnel syndrome.

You may not qualify if:

• Previous or current disease or trauma that might affect one or both upper limbs.
• Metabolic diseases that might associated with entrapment neuropathy such as diabetes mellitus, thyroid diseases, and autoimmune diseases.
• Pregnant women.
• Participants with congenital hand deformities.
• History of hand surgery.
• Sever cases of carpal tunnel syndrome that suffering from weakness of hand grip and atrophy of thenar muscle.

Sponsors & Collaborators

• Cairo University: lead

Study Sites (1)

Outpatient clinic faculty of physica therapy cairo university

Dokki, Egypt

Location

MeSH Terms

Conditions

Median Neuropathy; Carpal Tunnel Syndrome

Condition Hierarchy (Ancestors)

Mononeuropathies; Peripheral Nervous System Diseases; Neuromuscular Diseases; Nervous System Diseases; Nerve Compression Syndromes; Cumulative Trauma Disorders; Sprains and Strains; Wounds and Injuries

Study Officials

• Raghda Ahmed

  Cairo University

  PRINCIPAL INVESTIGATOR

Central Study Contacts

Raghda Ahmed

CONTACT

+201225615248; rodynody88@gmail.com

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: DOUBLE
• Who Masked: PARTICIPANT, INVESTIGATOR
• Purpose: TREATMENT
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Principal Investigator

Study Record Dates

• First Submitted: March 15, 2023
• First Posted: March 29, 2023
• Study Start: April 1, 2023
• Primary Completion: June 15, 2023
• Study Completion: August 15, 2023
• Last Updated: March 29, 2023

Record last verified: 2023-03

Locations

EG (1)