Dexmedetomidine Versus Triamcinolone Treatment in Carpal Tunnel Syndrome

NCT05624866 | Unknown

• 1 other identifier: 17200681
• Study Type: interventional
• Target: 60
• Locations: 1 country
• Sites: 1

Brief Summary

Carpal tunnel syndrome (CTS) is a common mononeuropathy due to entrapment of the median nerve in the carpal tunnel. a lot of modalities are available for treatment of mild to moderate CTS.

Conditions

Carpal Tunnel Syndrome

Outcome Measures

Primary Outcomes (1)

• pain visual analoge scale visual analog scale of pain value of (0 cm) no pain , and value of (10 cm) worst pain

  visual analog scale of pain value of (0 cm) no pain , and value of (10 cm) worst pain

  6 months

Secondary Outcomes (1)

• change of cross sectional area of the median nerve

  6 months

Study Arms (2)

Dexmeditomidine group

ACTIVE COMPARATOR

injection of 1 microgram/kg dexmeditomidine + 10 cc saline injection nearby median nerve as hydro-dissection

Drug: Dexmedetomidine

Triamcinolone group

ACTIVE COMPARATOR

injection of 40 mg triamcinolone + 10 cc saline injection nearby median nerve as hydro-dissection

Drug: Triamcinolone

Interventions

Dexmedetomidine DRUG

injection of 1 microgram/kg dexmeditomidine + 10 cc saline injection nearby median nerve as hydro-dissection

Dexmeditomidine group

Triamcinolone DRUG

injection of 40 mg triamcinolone + 10 cc saline injection nearby median nerve as hydro-dissection

Triamcinolone group

Eligibility Criteria

• Age: 20 Years - 60 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64)

You may qualify if:

• adult patients
• complaining of carpal tunnel syndrome of 3 month duration or more
• diagnosed axonal neuropathy using electrodiagnosis , nerve conduction study

You may not qualify if:

• patient refusal
• infection at the site of intervention
• allergy to utilized drugs
• diabetic
• previous surgery in the site of injection
• previous injection in the targeted site within the last year

Sponsors & Collaborators

• Assiut University: lead

Study Sites (1)

Assiut Universit Hospital

Asyut, Egypt

RECRUITING

MeSH Terms

Conditions

Carpal Tunnel Syndrome

Interventions

Dexmedetomidine; Triamcinolone

Condition Hierarchy (Ancestors)

Median Neuropathy; Mononeuropathies; Peripheral Nervous System Diseases; Neuromuscular Diseases; Nervous System Diseases; Nerve Compression Syndromes; Cumulative Trauma Disorders; Sprains and Strains; Wounds and Injuries

Intervention Hierarchy (Ancestors)

Imidazoles; Azoles; Heterocyclic Compounds, 1-Ring; Heterocyclic Compounds; Pregnadienes; Pregnanes; Steroids; Fused-Ring Compounds; Polycyclic Compounds; Steroids, Fluorinated

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: DOUBLE
• Who Masked: PARTICIPANT, OUTCOMES ASSESSOR
• Purpose: TREATMENT
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Professor

Model Details: Parallel Assignment Investigate if, and to what extent,carapl tunnel hydro-dissection using DEX or triamcinolone (TM) along with saline, under ultrasound guidance, can improve the clinical condition, change in nerve conduction parameters of patients with CTS and delay or avoid the surgical intervention.

Study Record Dates

• First Submitted: October 31, 2022
• First Posted: November 22, 2022
• Study Start: October 10, 2022
• Primary Completion: November 10, 2023
• Study Completion: December 10, 2023
• Last Updated: October 31, 2023

Record last verified: 2022-11

Locations

EG (1)