Study of Bronchiectasis and Associated Cardiovascular Comorbidities

NCT05783869 | Recruiting DMC

• 1 other identifier: 23455668
• Study Type: observational
• Target: 30
• Locations: 1 country
• Sites: 1

Brief Summary

Effect of cardiovascular comorbidities on disease severity and quality of life in Patients with acute exacerbation of non-cystic fibrosis bronchiectasis

Conditions

Bronchiectasis

Outcome Measures

Primary Outcomes (2)

• assessment of BNP (Brain natriuretic peptide) pg/ml levels in patients with bronchiectasis and cardiovascular comorbidities.

  Serum BNP (Brain natriuretic peptide) pg/ml will be compared in both groups.

  March 2023 to September 2023

• Assessment of Quality of life in patients and control groups using The Short Form (36) Health Survey (SF-36)

  The Short Form (36) Health Survey will be performed in both groups. The SF-36 consists of eight scaled scores, which are the weighted sums of the questions in their section. Each scale is directly transformed into a 0-100 scale on the assumption that each question carries equal weight. The lower the score the more disability. The higher the score the less disability i.e., a score of zero is equivalent to maximum disability and a score of 100 is equivalent to no disability.

  March 2023 to September 2023

Secondary Outcomes (1)

• Hospitalization frequency in patient group compared to control group.

  March 2023 to September 2023

Study Arms (2)

Patient with bronchiectasis and cardiovascular comorbidities

Patients with Bronchiectasis had no comorbidities other than cardiovascular comorbidities during the study period.

Device: Echocardiography

Patients with bronchiectasis and without cardiovascular comorbidities

Patients with Bronchiectasis had no comorbidities.

Device: Echocardiography

Interventions

Echocardiography DEVICE

echocardiographic study of both groups

Also known as: Pulmonary function test, Routine laboratory investigations and inflammatory markers

Patient with bronchiectasis and cardiovascular comorbidities; Patients with bronchiectasis and without cardiovascular comorbidities

Eligibility Criteria

• Age: 18 Years - 80 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Probability Sample

Study Population

all patients at the study period attending the chest department at Assuit university

You may qualify if:

• Any Patients with Bronchiectasis had no comorbidities other than cardiovascular comorbidities during the study period.

You may not qualify if:

• Any Patients who refuse to participate in the study.
• Any other comorbidity or end-organ failure may affect the study's result.

Sponsors & Collaborators

• Assiut University: lead
• Aliae AR Mohamed Hussein [ahussein: collaborator

Study Sites (1)

Assiut unviresty - Faculty of Medicine

Asyut, 71511, Egypt

RECRUITING

MeSH Terms

Conditions

Bronchiectasis

Interventions

Echocardiography; Respiratory Function Tests

Condition Hierarchy (Ancestors)

Bronchial Diseases; Respiratory Tract Diseases

Intervention Hierarchy (Ancestors)

Cardiac Imaging Techniques; Diagnostic Imaging; Diagnostic Techniques and Procedures; Diagnosis; Ultrasonography; Heart Function Tests; Diagnostic Techniques, Cardiovascular; Diagnostic Techniques, Respiratory System

Study Officials

• Ahmad Shaddad

  Assuit University Faculty of Medicine

  PRINCIPAL INVESTIGATOR

• Ahmad Shaddad

  Assiut University Faculty of Medicine

  PRINCIPAL INVESTIGATOR

Central Study Contacts

Shaadad Shaddad, MD

CONTACT

+201111171930; shaddad_ahmad@yahoo.com

Ahmad Shaddad, MD

CONTACT

+201111171930; shaddad_ahmad@yahoo.com

Study Design

• Study Type: observational
• Observational Model: CASE CONTROL
• Time Perspective: CROSS SECTIONAL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Lecturer of pulmonary medicine Assuit university

Study Record Dates

• First Submitted: February 12, 2023
• First Posted: March 24, 2023
• Study Start: March 25, 2023
• Primary Completion (Estimated): September 1, 2026
• Study Completion (Estimated): November 1, 2026
• Last Updated: May 11, 2025

Record last verified: 2025-05

Locations

EG (1)