HFNC in Management of Bronchiectasis Exacerbation

NCT05741697 | Recruiting DMC FDA Drug

• 1 other identifier: 2627378373
• Study Type: observational
• Target: 20
• Locations: 1 country
• Sites: 1

Brief Summary

Patients with Bronchiectasis experience exacerbations with hypercapnic respiratory failure associated with an increased respiratory workload that may require intensive care unit (ICU) admission due to the inability of the respiratory muscles to compensate for increased demand. These exacerbations are frequently treated with noninvasive ventilation (NIV).

Conditions

Bronchiectasis

Outcome Measures

Primary Outcomes (1)

• Assessment of efficacy and patient compliance of high flow nasal canula system in comparison to Noninvasive mechanical ventilation in management of acute exacerbation of Bronchiectasis

  The duration of ICU admission days and the patient compliance to both devices will be compared.

  March 2023 to December 2023

Study Arms (2)

Patient need NIV ventillation

Patients will be eligible for enrolment if they are diagnosed with bronchiectasis and admitted to the respiratory intensive care unit (RICU); requiring ventilator support without invasive mechanical ventilation and will need NIV

Drug: bi-level ventillation

patient need HFNC

Patients will be eligible for enrolment if they are diagnosed with bronchiectasis and admitted to the respiratory intensive care unit (RICU); requiring ventilator support without invasive mechanical ventilation and will need HFNC

Interventions

bi-level ventillation DRUG

non-invasive mechanical ventilation

Also known as: HFNC

Patient need NIV ventillation

Eligibility Criteria

• Age: 18 Years - 80 Years
• Sex: all
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Patients will be eligible for enrolment if diagnosed with bronchiectasis and admitted to the respiratory intensive care unit (RICU), requiring ventilator support without invasive mechanical ventilation.

You may qualify if:

• Patients will be eligible for enrolment if diagnosed with bronchiectasis and admitted to the respiratory intensive care unit (RICU), requiring ventilator support without invasive mechanical ventilation.

You may not qualify if:

• Age: less than 18 years. Patients with post-arrest encephalopathy. Patient with the previous tracheotomy. Patients who received invasive ventilatory support. Patients with end-organ failure.

Sponsors & Collaborators

• Assiut University: lead
• WGEKHALEEL: collaborator
• AARMHUSSIEN: collaborator

Study Sites (1)

Assiut University-Faculty of medicine

Asyut, Asyut Governorate, 71515, Egypt

RECRUITING

MeSH Terms

Conditions

Bronchiectasis

Condition Hierarchy (Ancestors)

Bronchial Diseases; Respiratory Tract Diseases

Study Officials

• Ahmad M. Shaddad

  Assiut University

  PRINCIPAL INVESTIGATOR

Central Study Contacts

ahmad shaddad, MD

CONTACT

+201111171930; shaddad_ahmad@yahoo.com

Study Design

• Study Type: observational
• Observational Model: CASE CONTROL
• Time Perspective: CROSS SECTIONAL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: lecturer of pulmonology

Study Record Dates

• First Submitted: February 12, 2023
• First Posted: February 23, 2023
• Study Start: March 1, 2023
• Primary Completion (Estimated): August 1, 2026
• Study Completion (Estimated): October 1, 2026
• Last Updated: April 30, 2026

Record last verified: 2026-04

Data Sharing

• IPD Sharing: Will not share

Locations

EG (1)