NCT05783739

Brief Summary

The goal of this study is to compare passive ankle and knee range of motion (ROM) development after surgery to the gastrocsoleus complex, in children with cerebral palsy (CP). The analysis will compare knee and ankle ROM development between types and levels of surgery performed to achieve lengthening of the gastrosoleus complex. Also, associations between treatment outcomes and Gross Motor Classification System level (GMFCS-level) as well as CP-subtype will be evaluated. This is a retrospective longitudinal study on the effects of gastrocsoleus complex lengthening on ROM development. The study is based on data from the Swedish Surveillance Program for Cerebral Palsy (CPUP)

Trial Health

100
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
186

participants targeted

Target at P50-P75 for all trials

Timeline
Completed

Started Jan 2000

Longer than P75 for all trials

Status
completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

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Study Timeline

Key milestones and dates

Study Start

First participant enrolled

January 1, 2000

Completed
13.9 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

December 1, 2013

Completed
Same day until next milestone

Study Completion

Last participant's last visit for all outcomes

December 1, 2013

Completed
9.3 years until next milestone

First Submitted

Initial submission to the registry

March 13, 2023

Completed
11 days until next milestone

First Posted

Study publicly available on registry

March 24, 2023

Completed
Last Updated

March 24, 2023

Status Verified

March 1, 2023

Enrollment Period

13.9 years

First QC Date

March 13, 2023

Last Update Submit

March 13, 2023

Conditions

Keywords

children, cerebral palsy, gastrocsoleus lengthening

Outcome Measures

Primary Outcomes (1)

  • Ankle ROM

    Polynomial regression coefficients describing mean ankle ROM development over follow-up time.

    Subjects will be followed from date of primary surgery to failure, the last assessment or end of study, at year 2022

Secondary Outcomes (3)

  • Knee ROM

    Subjects will be followed from date of primary surgery to failure, the last assessment or end of study, at year 2022

  • Composite endpoint

    Subjects will be followed from date of primary surgery to failure, the last assessment or end of study, at year 2022

  • Each component endpoint

    Subjects will be followed from date of primary surgery to failure, the last assessment or end of study, at year 2022

Study Arms (3)

Tendo Achilles Lengthening (TAL), percutaneous

Percutaneous lengthening of the achilles tendon.

Tendo Achilles Lengthening (TAL), open

Open surgery with lengthening of the achilles tendon.

Gastrocsoleus lengthening in zone 1 and 2

Lengthening of the gasrocnemius or its aponeurosis.

Eligibility Criteria

Age1 Year - 17 Years
Sexall
Healthy VolunteersNo
Age GroupsChild (0-17)
Sampling MethodNon-Probability Sample
Study Population

Children registered in CPUP Sweden (Follow up surveillance program for people with verebral palsy), treated with isolated surgical lengthening of the gastrocsoleus complex and born 2000-2011.

Contact the study team to confirm eligibility.

Sponsors & Collaborators

MeSH Terms

Conditions

Cerebral Palsy

Condition Hierarchy (Ancestors)

Brain Damage, ChronicBrain DiseasesCentral Nervous System DiseasesNervous System Diseases

Study Design

Study Type
observational
Observational Model
COHORT
Time Perspective
OTHER
Target Duration
7 Years
Sponsor Type
OTHER
Responsible Party
PRINCIPAL INVESTIGATOR
PI Title
Consultant Paediatric Orthopaedic Surgeon

Study Record Dates

First Submitted

March 13, 2023

First Posted

March 24, 2023

Study Start

January 1, 2000

Primary Completion

December 1, 2013

Study Completion

December 1, 2013

Last Updated

March 24, 2023

Record last verified: 2023-03