A Study Explore WJB001 Capsules in Patients With Advanced Solid Tumors

NCT05773820 | Recruiting Phase 1

• 1 other identifier: WJB001-001-I
• Study Type: interventional
• Target: 210
• Locations: 1 country
• Sites: 11

Brief Summary

This is a phase I/II study to evaluate the safety and tolerability, DLT(Dose limited toxicity), MTD(Maximum tolerated dose), and RP2D(Recommended phase II dose) of WJB001 capsules in patients with advanced solid tumors, including dose escalation phase, dose expansion phase and cohort expansion phase.The study includes screening, treatment and follow-up periods. In the Dose Escalation phase:Accelerated titration (the first two dose groups) and "BOIN" combination (the subsequent dose group) were used for dose escalation. In the Dose Expansion phase:Based on the previous data, 1 to 2 doses were selected to further evaluate the initial efficacy, safety, tolerability and pharmacokinetic characteristics to confirm RP2D. In the Efficacy Expansion phase:The preliminary plan of Efficacy expansion phase uses the Simon two-stage optimal method to expand 2 to 3 cohorts.

Conditions

Advanced Solid Tumors

Outcome Measures

Primary Outcomes (6)

• 1.Dose limited toxicity (DLT)

  incidence of Dose limited toxicity(DLT);

  21d

• 2.Adverse event (AE)

  incidence and severity of adverse event (AE), Abnormal changes in laboratory and other tests of clinical significance;

  3 years

• 3.Serious adverse event (SAE)

  incidence and severity of Serious adverse event (SAE);

  3 years

• 4.Maximum tolerated dose (MTD)

  Maximum tolerated dose (MTD)

  2 years

• 5.Recommended phase II dose (RP2D)

  Recommended phase II dose (RP2D)

  2 years

• 6.Objective response rate(ORR)

  Efficacy endpoints: Objective response rate(ORR) per RECIST v1.1

  3 years

Secondary Outcomes (19)

• 7. Peak time(Tmax)

  Prior to dose on day 1,5,8,12 and at 0.5,1,1.5, 2,3, 4, 6,8,10 and 24 hours post dose on day 1 and day 12 of Cycle 1

• 8.Maximum plasma concentration (Cmax)

  Prior to dose on day 1,5,8,12 and at 0.5,1,1.5, 2,3, 4, 6,8,10 and 24 hours post dose on day 1 and day 12 of Cycle 1

• 9. (AUC 0-t)

  Prior to dose on day 1,5,8,12 and at 0.5,1,1.5, 2,3, 4, 6,8,10 and 24 hours post dose on day 1 and day 12 of Cycle 1

• 10. (AUC 0-∞)

  Prior to dose on day 1,5,8,12 and at 0.5,1,1.5, 2,3, 4, 6,8,10 and 24 hours post dose on day 1 and day 12 of Cycle 1

• 11.Apparent volume of distribution (Vd/F)

  Prior to dose on day 1,5,8,12 and at 0.5,1,1.5, 2,3, 4, 6,8,10 and 24 hours post dose on day 1 and day 12 of Cycle 1

Other Outcomes (2)

• Biomarkers

  3 years

• QT interval

  2 years

Study Arms (1)

WJB001 capsules

EXPERIMENTAL

Dose Escalation: Accelerated titration (the first two dose groups) and "BOIN" combination (the subsequent dose group) were used for dose escalation. Dose Expansion: Based on the previous data, 1 to 2 doses were selected to further evaluate the initial efficacy, safety, tolerability and pharmacokinetic characteristics to confirm RP2D. Cohort Expansion: The preliminary plan of cohort expansion phase uses the Simon two-stage optimal method to expand 2 to 3 cohorts.

Drug: WJB001

Interventions

WJB001 DRUG

WJB001 Capsules:160mg(or othe dosages),Oral,QD,Days 1-5, 8-12, 15-19 or other dosing frequencies,Every 21 days

WJB001 capsules

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• ≥ 18 years or older at the time of informed consent；
• Patient with advanced malignant solid tumors clearly diagnosed pathologically and/or cytologically, who have failed to receive standard treatment, or who currently no have standard treatment, or who are intolerant to standard treatment;
• Eastern Cooperative Oncology Group (ECOG) Performance Status (PS) score ≤1;
• Life expectancy ≥ 12 weeks;
• Adequate hematologic and organ function；
• All acute toxic effects from previous antineoplastic therapy or surgery ；
• At least one measurable tumor lesion that meets the definition of RECIST v1.1, with no history of biopsy two weeks before screening(applicable to all stages);
• Subjects with CCNE1 overexpression confirmed by central laboratory (applicable to the dose expansion stage and efficacy expansion stage);
• For subjects with advanced uterine serous carcinoma, ≤2 lines of therapy for recurrence are allowed after first-line treatment; For subjects with advanced high-grade serous ovarian, fallopian tube, or peritoneal cancer,≤2 lines of therapy after platinum resistance are allowed(applicable to the dose expansion stage and efficacy expansion stage)；

You may not qualify if:

• General condition 1) Pregnant or lactating women; 2) Any known allergies to or contraindications to components of the study drug; 3) History of substance abuse; 4) History of alcohol abuse or consumption of more than 28 units of alcohol per week (1 unit =285 ml beer or 25 ml spirits (40%v/v) or 100 ml wine).
• Previous or current treatment:
• \) Previous or current treatment with Wee1 inhibitors; 2) Received cytotoxic chemotherapy drugs,anti-tumor traditional Chinese medicine orother anti-tumor therapies (such as small molecule targeted therapy, etc.)within 4 weeks prior to the first administration of study drug;Or received the investigational drug, macromolecular drug with anti-tumor effect (e.g., monoclonal antibody, antibody-drug conjugate, or bispecific antibody, etc.) within 28 days prior to the first administration of study drug; Or need to continue receiving these medications during the study; 3) The use of a medium or strong inhibitor or inducer of CYP3A or other product (e.g., grapefruit juice) or P-gp inhibitor or inducer was discontinued less than the time before the first dose of WJB001 was administered 5 half-lives of the drug or 14 days, whichever is shorter; 4) Patients with a known organ transplant or stem cell transplant; Major surgery or major trauma (excluding needle biopsy for sample collection) within 4 weeks prior to the first administration of study drug; 5) Radiation therapy was administered within 21 days prior to the first administration of study drug; (except the radiation was delivered to ≤5% of bone marrow volume).3. Past medical history, present medical history and abnormal laboratory indicators:
• \. Abnormal laboratory indicators:
• Having active GI abnormalities including, but not limited to, inability to take oral medication, need for intravenous nutritional support, peptic ulcer, chronic diarrhea (e.g., Crohn's disease, irritable bowel syndrome), or vomiting or other factors that the investigator believes may significantly affect drug absorption, metabolism, or excretion;
• History of severe ocular disease (except permanent blindness due to disease) that has not recovered to grade 1 or less;
• Patients with active brain metastases (except if they had CNS metastases confined to the supratentorial or cerebellar region, had been adequately treated (surgery or radiotherapy), had maintained radiological stability for at least 4 weeks, and did not require corticosteroids for symptom control);
• Patients with current cancer meningitis or spinal cord compression;
• Severe or poorly controlled hypertension, including previous history of hypertensive crisis or hypertensive encephalopathy; Adjustment of antihypertensive medication due to poor blood pressure control within 2 weeks before the first dose;Systolic blood pressure ≥160 mmHg or diastolic blood pressure ≥100 mmHg during the screening period;
• Patients with clinically significant bleeding symptoms or obvious bleeding tendency within 4 weeks before the first dose, such as gastrointestinal bleeding, gastric ulcer bleeding, obvious gross hematuria, or angiitis;
• Patients with active HBV and HCV infection: if HBsAg is positive or/and anti-HBc is positive, blood HBV DNA should be tested to confirm that it is above the limit of quantitative detection; If anti-HCV is positive, it is necessary to detect HCV RNA to confirm that the HCV virus copy number exceeds the quantitative detection limit；
• Known history of human immunodeficiency virus infection or seropositivity for HIV;
• History of syphilis (both treponema pallidum specific and non-specific antibodies were positive)；
• History of other primary solid tumor (except a cured solid tumor that has been inactive for ≥5 years before screening and has a very low risk of recurrence）; Adequately treated non-melanoma skin cancer or lentigo maligna with no evidence of disease recurrence; Adequately treated carcinoma in situ with no evidence of disease recurrence, such as carcinoma in situ of the cervix);
• history of severe or what the investigators considered clinically significant cardiac disease affected the safety assessment；

Sponsors & Collaborators

• Wigen Biomedicine Technology (Shanghai) Co., Ltd.: lead
• Sponsor GmbH: collaborator

Study Sites (11)

Cancer Hospital Chinese Academy of Medical Sciences

Beijing, Beijing Municipality, 100021, China

RECRUITING

Fujian Cancer Hospital

Fuzhou, Fujian, 350000, China

RECRUITING

Sun Yat-sen University Cancer Center

Guangzhou, Guangdong, 510000, China

RECRUITING

Tumor Hospital Affiliated to Guangxi Medical University

Nanning, Guangxi, 530000, China

RECRUITING

Union Hospital, Tongji Medical College, Huazhong University of Science and Technology

Wuhan, Hubei, 430023, China

RECRUITING

Hunan Cancer Hospital

Changsha, Hunan, 410000, China

RECRUITING

Fuxin People's Hospital (Fuxin Women and Children's Medical Center)

Fuxin, Liaoning, 123000, China

NOT YET RECRUITING

Liaoning Cancer Hospital

Shenyang, Liaoning, 110000, China

RECRUITING

Shanxi Cancer Hospital

Taiyuan, Shanxi, 030000, China

RECRUITING

The First Affiliated Hospital of Xi 'an Jiaotong University

Xi’an, Shanxi, 710061, China

RECRUITING

Henan Cancer Hospital

Henan, Zhenzhou, 450000, China

RECRUITING

Study Officials

• Lingying Wu, Professor

  Cancer Institute and Hospital, Chinese Academy of Medical Sciences

  PRINCIPAL INVESTIGATOR

Central Study Contacts

Yirong Zhao, Medical Director

CONTACT

86 15221069447; yrzhao@wigenbio.com

Study Design

• Study Type: interventional
• Phase: phase 1
• Allocation: NA
• Masking: NONE
• Purpose: TREATMENT
• Intervention Model: SEQUENTIAL
• Sponsor Type: INDUSTRY
• Responsible Party: SPONSOR

Model Details: Sequential

Study Record Dates

• First Submitted: February 16, 2023
• First Posted: March 17, 2023
• Study Start: May 5, 2023
• Primary Completion (Estimated): August 8, 2026
• Study Completion (Estimated): May 23, 2027
• Last Updated: April 1, 2026

Record last verified: 2026-03

Data Sharing

• IPD Sharing: Will not share

Locations

CN (11)