An Open-label, Multi-center, Dose-escalation and Cohort Expansion Phase I/IIa Clinical Study to Evaluate the Safety, Tolerability, Pharmacokinetic Profile and Efficacy of ACR246 in Patients With Advanced Solid Tumors

NCT06238401 | Recruiting Phase 1

• 1 other identifier: ACR246-101
• Study Type: interventional
• Target: 77
• Locations: 1 country
• Sites: 6

Brief Summary

The goal of the study is to evaluate the safety and tolerability of ACR246 in patients with advanced solid tumors, to determine the maximum tolerated dose (MTD) and Phase II recommended dose (RP2D) of ACR246.

Conditions

Advanced Solid Tumors

Outcome Measures

Primary Outcomes (1)

• Safety and tolerability:

  Incidence and characteristics of adverse events (AEs), serious adverse events (SAEs) and dose-limiting toxicities (DLTs).

  21days

Secondary Outcomes (8)

• PK parameters of ACR246（Cmax）

  21days

• PK parameters of ACR246（Tmax）

  21days

• PK parameters of ACR246（t1/2）

  21days

• PK parameters of ACR246（AUC0-t）

  21days

• PK parameters of ACR246（AUC0-∞）

  21days

Study Arms (1)

ACR246 for injection

EXPERIMENTAL

Administered by intravenous infusion on Day 1 every 3 weeks (Q3W).

Drug: ACR246 for injection

Interventions

ACR246 for injection DRUG

80 mg/vial

ACR246 for injection

Eligibility Criteria

• Age: 18 Years - 75 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Be willing to sign the ICF, be able to understand the study, and be willing to follow and be able to complete all the study procedures;
• Male and female, aged 18 to 75 years (inclusive);
• For phase I dose escalation study: Patients with histologically or cytologically confirmed recurrent or metastatic unresectable advanced solid tumors who experience disease progression after receiving systemic standard therapy, or have no standard therapy;
• For phase IIa cohort escalation study: Patients with histologically or cytologically confirmed recurrent or metastatic unresectable advanced solid tumors who experience disease progression after receiving systemic standard therapy, or have no standard therapy, including the following malignant tumors:
• Esophageal cancer: Patients who experience disease progression after receiving prior ≥2 lines of chemotherapy;
• Colorectal cancer: Patients who experience disease progression after receiving prior ≥2 lines of chemotherapy;
• NSCLC: Patients with NSCLC meet the following conditions, and are unable to continue subsequent standard of care or have no standard of care available as judged by the investigator:
• i. Positive for driver genes (such as EGFR, ALK, ROS1, MET); disease progression after current standard targeted therapy; ii. Negative for driver genes (such as EGFR, ALK, ROS1, MET); disease progression after prior ≥1 line(s) of therapy, and use of platinum-based drugs in at least one regimen; d) Ovarian cancer: Patients who experience disease progression after receiving at least one prior line of chemotherapy; the patient must receive prior treatment with PARP inhibitors if harboring BRCA 1/2 mutations; e) Prostate cancer: Patients with metastatic castration-resistant prostate cancer who receive at least one prior systemic therapy; f) Other solid tumors: Patients who experience disease progression after receiving prior standard of care, have no standard of care available, or are currently unsuitable to receive standard of care.
• Positive for 5T4 expression as detected by the central laboratory (phase IIa only);
• Phase I: Presence of at least one evaluable lesion by imaging as per RECIST v1.1; phase IIa: Presence of at least one measurable lesion by imaging as per RECIST v1.1. Lesions that are previously treated with radiotherapy cannot be considered target lesions unless the lesions have unequivocal progression;
• Toxicity from prior antitumor therapies returned to Grade ≤1 as defined by NCI-CTCAE v5.0, but with the exception for alopecia- or antitumor therapy-associated events that can be tolerated by patients as judged by the investigator;
• Eastern Cooperative Oncology Group (ECOG) performance status score of ≤1;
• Adequate bone marrow, liver, kidney, and coagulation functions (refer to the upper limit of normal \[ULN\] of each clinical study site):
• Bone marrow (did not receive blood transfusion or use drugs that increase white blood cells and platelets, e.g., cytokines or erythropoietin, within 2 weeks prior to laboratory tests):
• Absolute neutrophil count (ANC) count ≥1.5×109/L; Platelet (PLT) ≥100×109/L; Haemoglobin (Hb) ≥90 g/L;

You may not qualify if:

• Patients meeting any of the following criteria should be excluded from the study:
• Comorbid with other primary malignant tumors, except for:
• Resolved non-invasive basal cell carcinoma or squamous cell carcinoma, and cervical carcinoma in situ;
• Or other malignant tumors with a more than 5-year disease free survival;
• Malignant tumors other than those with a more than 5-year disease free survival, but the patient may obtain benefits after enrollment as he/she has a stable condition assessed by the investigator (for phase I dose escalation study only);
• Received any systemic antitumor therapies (including chemotherapy, radiotherapy, biological therapy, immunotherapy, etc.) within 4 weeks prior to the first dose of the investigational drug; Received small molecule targeted drugs, Chinese herbal medicines or Chinese patent medicines with antitumor indications or systemic immunomodulators (including but not limited to interferon, interleukin-2, and tumor necrosis factor) within 2 weeks prior to the first dose of the investigational drug;
• Prior treatment with any 5T4-targeted drug therapy;
• Known hypersensitivity to any of the active ingredients or excipients of ACR246, or documented history of allergy to protein drugs, experienced other serious allergic reactions, for which, the patient is not suitable to receive ACR246 as assessed by the investigator;
• History of severe heart disease as assessed by the investigator, e.g., symptomatic cardiac failure congestive (CHF) \[Class ≥2 as per New York Heart Association (NYHA) functional classification\], and history of myocardial infarction or unstable angina pectoris within 6 months prior to screening;
• Serious arrhythmia requiring medication, e.g., corrected QT interval (Frederica formula) \>450 msec for male or \>470 msec for female, complete left bundle branch block, third-degree atrioventricular block;
• Uncontrolled hypertension after medication treatment (systolic blood pressure ≥160 mmHg or diastolic blood pressure ≥100 mmHg);
• Dyspnoea at rest, severe primary pulmonary disorder currently requiring continuous oxygen therapy, history of interstitial lung disease and radiation pneumonitis, uncontrolled or potential risk of pulmonary fibrosis, or clinically active lung diseases as indicated by any proof;
• Serious or uncontrolled systemic diseases (e.g., unstable or uncompensated respiratory, heart, liver or kidney diseases), as assessed by the investigator;
• Positive antibody tests for active hepatitis B (hepatitis B surface antigen positive and HBV DNA≥1×103 IU/mL), active hepatitis C (hepatitis C antibody positive and HCV RNA \> lower limit of detection), active syphilis (treponema pallidum antibody positive and Rapid Plasma Reagin (RPR) titer positive), and human immunodeficiency virus (HIV) antibody positive, or any uncontrolled infections;
• Had a major surgery or serious traumatic injuries (without complete recovery as assessed by the investigator) within 4 weeks prior to the first dose of the investigational drug, or plans to undergo a major surgery during the study;

Sponsors & Collaborators

• Hangzhou Adcoris Biopharmacy Co., Ltd: lead

Study Sites (6)

Cancer Hospital Chinese Academy of Medical Sciences

Beijing, Beijing Municipality, 100021, China

RECRUITING

Beijing Tumor Hospital

Beijing, Beijing Municipality, 100142, China

RECRUITING

Zhejiang Cancer Hospital

Zhejiang, Hangzhou, 310022, China

RECRUITING

Shandong First Medical University affiliated Cancer Hospital of Shandong

Shandong, Jinan, 250117, China

RECRUITING

ShangHai Chest Hospital

Shanghai, Shanghai Municipality, 200030, China

RECRUITING

ShangHai Sixth People's Hospital

Shanghai, Shanghai Municipality, 200233, China

RECRUITING

MeSH Terms

Interventions

Injections

Intervention Hierarchy (Ancestors)

Drug Administration Routes; Drug Therapy; Therapeutics

Central Study Contacts

Lina Chen

CONTACT

0571-83580689; chenln@adcoris.com.cn

Study Design

• Study Type: interventional
• Phase: phase 1
• Allocation: NA
• Masking: NONE
• Purpose: TREATMENT
• Intervention Model: SINGLE GROUP
• Sponsor Type: INDUSTRY
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: January 17, 2024
• First Posted: February 2, 2024
• Study Start: October 29, 2024
• Primary Completion (Estimated): May 30, 2026
• Study Completion (Estimated): November 30, 2026
• Last Updated: November 24, 2025

Record last verified: 2025-03

Data Sharing

• IPD Sharing: Will not share

Locations

CN (6)