Double Anaerobic Threshold in Athletes

NCT05770453 | Unknown

• 1 other identifier: CCM 1719
• Study Type: observational
• Target: 100
• Locations: 1 country
• Sites: 3

Brief Summary

During an incremental cardiopulmonary exercise test (CPET) performed with a ramp protocol, it is very important to determine the anaerobic threshold, defined as the point at which the metabolism switches from being predominantly aerobic to also being anaerobic. The anaerobic threshold can be determined invasively, by identifying the increase in blood lactates with an arterial sampling, or, more commonly, non-invasively by three methods: the V-slope method, the ventilatory equivalents method and by using end-expiratory oxygen and carbon dioxide pressure (PETO2 and PETCO2 respectively). Normally, the anaerobic threshold is determined by the first method and the other two are used to confirm the value. The finding of different anaerobic threshold values using these three methods has been reported anecdotally in the past, while a prevalence of 11% in a healthy population has recently been described. Regular training, particularly that aimed at endurance sports, is able to shift the anaerobic threshold to higher exercise intensities. At present, the physiological reasons for the presence of a double threshold are unclear. The aim of the study is to identify the anaerobic threshold by means of the V-slope method and by means of the ventilatory equivalents method in athletes who have performed an incremental ramp CPET at the laboratories of the investigating centres, to assess in how many athletes a double threshold is present and to try to interpret the physiological/ pathophysiological significance of this finding. In this retrospective and prospective observational study, healthy male and female athletes who have had a cardiopulmonary test at our laboratories from 2007 to the present (retrospectively recruited) and prospectively recruited until the calculated sample size is reached will be enrolled.

Conditions

Cardiopulmonary Exercise Test; Anaerobic Threshold; Athlete

Outcome Measures

Primary Outcomes (1)

• Athletes groups

  Identification of two groups of athletes (those with identified double anaerobic threshold and those without)

  immediately after the incremental cardiopulmonary exercise test evaluation

Secondary Outcomes (9)

• Groups differences in age

  immediately after the incremental cardiopulmonary exercise test evaluation

• Groups differences in sport practised

  immediately after the incremental cardiopulmonary exercise test evaluation

• Groups differences in exercise performance

  immediately after the incremental cardiopulmonary exercise test evaluation

• Groups differences in VO2

  immediately after the incremental cardiopulmonary exercise test evaluation

• Groups differences in VE/VCO2 slope

  immediately after the incremental cardiopulmonary exercise test evaluation

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Probability Sample

Study Population

Healthy male and female athletes who performed a cardiopulmonary test at our laboratories from 2007 to the present (retrospectively recruited) and prospectively recruited will be enrolled

You may qualify if:

• no major present or past illnesses, no ongoing treatment
• At least 2 training sessions per week.

You may not qualify if:

• Current illnesses and treatments for any physical condition that could potentially alter performance
• Subjects who have performed a submaximal test (RER \< 1.05)
• CPET during which the AT determination is poorly assessable, i.e. due to changes in respiration.
• obese subjects (BMI \>30)

Sponsors & Collaborators

• Centro Cardiologico Monzino: lead
• Azienda Ospedaliero-Universitaria Careggi: collaborator
• University of Foggia: collaborator

Study Sites (3)

Azienda Ospedaliero-Universitaria Careggi

Florence, Italy

RECRUITING

University of Foggia

Foggia, Italy

NOT YET RECRUITING

Centro Cardiologico Monzino

Milan, 20138, Italy

RECRUITING

Study Officials

• Piergiuseppe Agostoni, Prof.

  Centro Cardiologico Monzino

  PRINCIPAL INVESTIGATOR

Central Study Contacts

Piergiuseppe Agostoni, Prof

CONTACT

+39 0258002772; piergiuseppe.agostoni@cardiologicomonzino.it

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: OTHER
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: February 21, 2023
• First Posted: March 15, 2023
• Study Start: March 15, 2022
• Primary Completion: December 1, 2023
• Study Completion: December 1, 2023
• Last Updated: March 15, 2023

Record last verified: 2023-02

Locations

IT (3)