Trials Sponsors Conditions Drugs Pricing

Conditions

Muscle Atrophy

Keywords

ultrasoundmri

Outcome Measures

Primary Outcomes (3)

Ultrasound muscle thickness (cm)
A single ultrasound image can measure both thickness (cm) and echogenecity (AU). Echogenecity has been used as a proxy for fat infiltration. By combining both thickness and fat infiltration and index of muscle quality can be determined
1 year
Ultrasound echogenecity (arbitrary units on histogram)
A single ultrasound image can measure both thickness (cm) and echogenecity (AU). Echogenecity has been used as a proxy for fat infiltration. By combining both thickness and fat infiltration and index of muscle quality can be determined
1 year
Fat fraction
Obtained from MRI and will be used to validate the ultrasound echogenecity
1 year

Study Arms (2)

Older

16 older (\>50y) will be recruited. MRI, MRS and Ultrasound will be measured in each participant in calf and thigh muscle, at the same location within a 1 hour time frame.

Diagnostic Test: MRI, MRSDiagnostic Test: Ultrasound

Young

16 young (\<40y) will be recruited. MRI, MRS and Ultrasound will be measured in each participant in calf and thigh muscle, at the same location within a 1 hour time frame.

Diagnostic Test: MRI, MRSDiagnostic Test: Ultrasound

Interventions

MRI, MRSDiagnostic test

Scan of right calf and thigh

OlderYoung

UltrasoundDiagnostic test

Scan of right calf and thigh

OlderYoung

Eligibility Criteria

Age18 Years+

Sexall

Healthy VolunteersYes

Age GroupsAdult (18-64), Older Adult (65+)

Sampling MethodNon-Probability Sample

Study Population

General population

You may qualify if:

\- Age \<40y or \>50yrs

You may not qualify if:

Sponsors & Collaborators

University of Exeter
Otherlead

Study Sites (1)

University

Exeter, Devon, EX2 4TH, United Kingdom

MeSH Terms

Conditions

Muscular Atrophy

Interventions

Magnetic Resonance ImagingPositron-Emission TomographyUltrasonography

Condition Hierarchy (Ancestors)

Neuromuscular ManifestationsNeurologic ManifestationsNervous System DiseasesAtrophyPathological Conditions, AnatomicalPathological Conditions, Signs and SymptomsSigns and Symptoms

Intervention Hierarchy (Ancestors)

Tomography

Study Officials

Francis Stephens
University of Exeter
PRINCIPAL INVESTIGATOR

Enrollment

30 participants (actual enrollment reported by the registry).

Study Design

Study Type: observational
Observational Model: COHORT
Time Perspective: CROSS SECTIONAL
Sponsor Type: OTHER
Responsible Party: SPONSOR

Study Record Dates

First Submitted

January 16, 2023

First Posted

February 15, 2023

Study Start

June 10, 2022

Actual (reported)

Can Ultrasound be Used as a Measure of Muscle Quality? A Validation Study Comparing Ultrasound With MRI and MRS in Older and Younger Persons.

Brief Summary

Registry Overview

Trial Relationships

Study Timeline

Study Start

Primary Completion

First Submitted

First Posted

Study Completion

Conditions

Keywords

Outcome Measures

Primary Outcomes (3)

Study Arms (2)

Older

Young

Interventions

Eligibility Criteria

You may qualify if:

You may not qualify if:

Sponsors & Collaborators

Study Sites (1)

MeSH Terms

Conditions

Interventions

Condition Hierarchy (Ancestors)

Intervention Hierarchy (Ancestors)

Study Officials

Enrollment

Study Design

Study Record Dates

Data Sharing

Source record

Locations

Brief Summary

Registry Overview

Trial Relationships

Related Scientific Literature

Study Timeline

Study Start

Primary Completion

First Submitted

First Posted

Study Completion

Conditions

Keywords

Outcome Measures

Primary Outcomes (3)

Study Arms (2)

Older

Young

Interventions

Eligibility Criteria

You may qualify if:

You may not qualify if:

Sponsors & Collaborators

Study Sites (1)

MeSH Terms

Conditions

Interventions

Condition Hierarchy (Ancestors)

Intervention Hierarchy (Ancestors)

Study Officials

Enrollment

Study Design

Study Record Dates

Data Sharing

Source record

Locations