Beta-lactoglobulin, Immobilisation and Muscle Protein Synthesis
Effect of Beta-lactoglobulin Supplementation on the Response of Muscle Protein Synthesis During Limb Immobilisation in Healthy Young Adults
1 other identifier
interventional
24
1 country
1
Brief Summary
The objectives of this study are to:
- 1.Establish whether combined β-lactoglobulin supplementation and resistance training for 1 week prior to 5 days of limb immobilisation will attenuate the decrease in integrated free-living rates of MPS during short-term muscle disuse.
- 2.Establish whether combined β-lactoglobulin supplementation and resistance training for 1 week prior to limb immobilisation will attenuate the decrease in muscle mass and strength during short-term muscle disuse.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at below P25 for not_applicable
Started Apr 2023
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
Click on a node to explore related trials.
Study Timeline
Key milestones and dates
First Submitted
Initial submission to the registry
August 9, 2022
CompletedFirst Posted
Study publicly available on registry
August 11, 2022
CompletedStudy Start
First participant enrolled
April 1, 2023
CompletedPrimary Completion
Last participant's last visit for primary outcome
March 1, 2024
CompletedStudy Completion
Last participant's last visit for all outcomes
August 1, 2024
CompletedApril 26, 2023
August 1, 2022
11 months
August 9, 2022
April 24, 2023
Conditions
Outcome Measures
Primary Outcomes (1)
Muscle protein synthesis
The synthesis of amino acids into new muscle protein.
15 days
Secondary Outcomes (1)
Muscle mass
15 days
Study Arms (2)
Beta-lactoglobulin
EXPERIMENTALDaily supplementation over 12 day period. A nutritional supplement.
Carbohydrate
PLACEBO COMPARATORDaily supplementation over 12 day period. Energy matched control.
Interventions
Beta-lactoglobulin (BLG) will be administered thrice daily during a 7 day period of prehabilitation and 5 day period of immobilisation when the leg is placed in a brace.
Carbohydrate (dextrose monohydrate) will be administered thrice daily during a 7 day period of prehabilitation and 5 day period of immobilisation when the leg is placed in a brace.
Eligibility Criteria
You may qualify if:
- Male and female
- Aged 18-45 years
- Healthy
- Physically active (≥150-300 minutes of moderate-intensity aerobic physical activity per week OR 75-150 minutes of vigorous-intensity aerobic physical activity per week)
- Eumenorrheic and not taking any hormonal birth control (females)
You may not qualify if:
- Dairy allergy or intolerance
- Lower limb injury or surgery in the last 6 months,
- Lower limb osteoarthritis or other musculoskeletal disorder
- A musculoskeletal or blood blotting disorder
- An allergy to local anaesthetic
- Currently pregnant
- Current use of blood thinning medications
- Volunteers that take part in structured resistance exercise training
- Taking supplements considered to be anabolic to skeletal muscle (protein supplements, creatine, or omega-3 supplements)
- Consuming more than 1.2 grams of protein per kilogram of body mass per day in their habitual diet.
- Volunteers involved in other studies at the time of enrolment
- Volunteers who have taken part in a tracer study in the past 18 months
- If without an understanding of verbal or written English
- Volunteers with a history of eating disorders
Contact the study team to confirm eligibility.
Sponsors & Collaborators
- King's College Londonlead
- University of Nottinghamcollaborator
Study Sites (1)
King's College London
London, SE1 9NH, United Kingdom
Related Publications (1)
Hughes A, Francis T, Marjoram L, Rooney JH, Ellison-Hughes G, Pollock R, Curtis MJ, Cape A, Larsen M, Phillips BE, Atherton PJ, Smith K, Witard OC. The effect of combined beta-lactoglobulin supplementation and resistance exercise training prior to limb immobilisation on muscle protein synthesis rates in healthy young adults: study protocol for a randomised controlled trial. Trials. 2023 Jun 13;24(1):401. doi: 10.1186/s13063-023-07329-6.
PMID: 37312095DERIVED
MeSH Terms
Conditions
Interventions
Condition Hierarchy (Ancestors)
Intervention Hierarchy (Ancestors)
Study Officials
- PRINCIPAL INVESTIGATOR
Oliver Witard, PhD
King's College London
Central Study Contacts
Study Design
- Study Type
- interventional
- Phase
- not applicable
- Allocation
- RANDOMIZED
- Masking
- DOUBLE
- Who Masked
- PARTICIPANT, INVESTIGATOR
- Masking Details
- Double blinded to supplement (beta-lactoglobulin or carbohydrate)
- Purpose
- PREVENTION
- Intervention Model
- PARALLEL
- Sponsor Type
- OTHER
- Responsible Party
- SPONSOR
Study Record Dates
First Submitted
August 9, 2022
First Posted
August 11, 2022
Study Start
April 1, 2023
Primary Completion
March 1, 2024
Study Completion
August 1, 2024
Last Updated
April 26, 2023
Record last verified: 2022-08
Data Sharing
- IPD Sharing
- Will not share
Data will be presented in form of peer reviewed manuscript. While individual data will be presented, these data will not be identifiable to other researchers.