NCT05719415

Recruiting

Functional Pulmonary Capillary Surface Area in BPA for CTEPH

Jewish General Hospital Source

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Other study identifiers

Sponsor study identifier

00-034 (3)

Study Type

interventional

Estimated enrollment

40

Locations

1 country

Sites

1

Timeline

Study Start

March 23, 2023

Actual (reported)

Primary Completion

January 30, 2028

Estimated

Planned date reported by the registry; this milestone is not confirmed as achieved.

Study Completion

January 30, 2028

Estimated

Planned date reported by the registry; this milestone is not confirmed as achieved.

Brief Summary

Chronic thromboembolic pulmonary hypertension \[CTEPH\] is caused by pulmonary emboli that have enlarged in pulmonary arteries and have become organized into the vessel wall. Many patients with CTEPH are treated with balloon pulmonary angioplasty \[BPA\] which mechanically opens the narrow pulmonary arteries. It is unclear how much downstream functional pulmonary capillary surface area \[FCSA\] is recovered during BPA. The investigators plan to measure FCSAIn CTEPH patients, before and after a session of BPA.

Registry Overview

Registry-reported information. Elapsed time and enrollment totals alone do not measure study progress or recruitment pace.

Recruitment status: recruiting
Estimated enrollment: 40 participants
Study completion date: January 30, 2028
Estimated
Planned date reported by the registry; this milestone is not confirmed as achieved.
Listed locations: 1 countries · 1 sites

Trial Relationships

Click on a node to explore related trials.

Some registry-reported names shown below are not yet linked in this graph.

Study Timeline

Dates and qualifiers reported by the registry. Estimated dates do not confirm that a milestone has occurred.

First Submitted
January 30, 2023
Actual (reported)
First Posted
February 9, 2023
Actual (reported)
Study Start
March 23, 2023
Actual (reported)
Primary Completion
January 30, 2028
Estimated
Planned date reported by the registry; this milestone is not confirmed as achieved.
Study Completion
January 30, 2028
Estimated
Planned date reported by the registry; this milestone is not confirmed as achieved.

Last Updated: September 23, 2025
Status Verified: September 2025
Last Update Submitted: September 22, 2025

Conditions

Hypertension, Pulmonary Pulmonary Thromboembolisms

Outcome Measures

Primary Outcomes (1)

Change in pulmonary functional capillary surface area
Measurement of transpulmonary metabolism of benzoyl-Phe-Ala-Pro
4 hours

Study Arms (1)

Pre and post BPA

EXPERIMENTAL

Other: Measurement of pulmonary functional capillary surface area

Interventions

Measurement of pulmonary functional capillary surface areaOther

Measurement of transpulmonary metabolism of trace injected doses of benzoyl-Phe-Ala-Pro

Pre and post BPA

Registry-reported names are shown in full. Names without a link have not yet been matched to a Syfrah profile.

Eligibility Criteria

Age18 Years - 75 Years

Sexall

Healthy VolunteersNo

Age GroupsAdult (18-64), Older Adult (65+)

You may qualify if:

All patients eligible for balloon pulmonary angioplasty for chronic thromboembolic pulmonary hypertension

You may not qualify if:

Sponsors & Collaborators

Jewish General Hospital
Otherlead

Study Sites (1)

David Langleben

Montreal, Quebec, H3W 2C4, Canada

RECRUITING

David LanglebenCONTACT5143407531 david.langleben@mcgill.ca

David Langleben, MDPRINCIPAL INVESTIGATOR

MeSH Terms

Conditions

Hypertension, PulmonaryPulmonary Embolism

Condition Hierarchy (Ancestors)

Lung DiseasesRespiratory Tract DiseasesHypertensionVascular DiseasesCardiovascular DiseasesEmbolismEmbolism and Thrombosis

Central Study Contacts

David Langleben, MD

CONTACT

5143407531 david.langleben@mcgill.ca

Lyda Lesenko, MD

CONTACT

514-340-8222

Study Design

Study Type: interventional
Phase: not applicable
Allocation: NA
Masking: NONE
Purpose: BASIC SCIENCE
Intervention Model: SINGLE GROUP
Sponsor Type: OTHER
Responsible Party: PRINCIPAL INVESTIGATOR
PI Title: Professor of Medicine

Study Record Dates

First Submitted

January 30, 2023

First Posted

February 9, 2023

Study Start

March 23, 2023

Actual (reported)

Primary Completion

January 30, 2028

Estimated

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Not ApplicableRecruiting

NCT07149935

Continuous Effect Of Rehabilitation Training On Pulmonary Arterial Hypertension Patients

Not ApplicableRecruiting

NCT05901168

Acute Responses of Active Video Games and Traditional Exercise Program in in Patients With Pulmonary Hypertension

Not ApplicableCompleted

NCT06079151

Hemodynamic Effect of Nasal High-flow in Patients Suspected or Followed for a Precapillary Pulmonary Hypertension

Not ApplicableUnknown

NCT06206967

Promotion of Active Lifestyle in Thromboembolism Patients

Not ApplicableUnknown

Treatment with angiotensin-converting enzyme inhibitors or angiotensin receptor blockers,

Presence of patent foramen ovale

Contact the study team to confirm eligibility.

llesenko@jgh.mcgill.ca

Planned date reported by the registry; this milestone is not confirmed as achieved.

Study Completion

January 30, 2028

Estimated

Planned date reported by the registry; this milestone is not confirmed as achieved.

Last Updated

September 23, 2025

Record last verified: 2025-09

Data Sharing

IPD Sharing: Will not share

Source record

Download the complete ClinicalTrials.gov record imported by Syfrah, including fields not shown in this page. The registry may contain a newer revision.

Source: ClinicalTrials.gov.

JSON downloads include source attribution and retrieval details alongside the unchanged original record or the separately normalized values.

Registry identifier: NCT05719415
Data provider: ClinicalTrials.gov
Source updated: 2025-09-23
Normalization version: ctgov-legacy-1

Open registry record

Source retrieved: 2026-10-25 22:30:45 UTC

Locations

CA(1)

Brief Summary

Registry Overview

Trial Relationships

Related Scientific Literature

Study Timeline

First Submitted

First Posted

Study Start

Primary Completion

Study Completion

Conditions

Outcome Measures

Primary Outcomes (1)

Study Arms (1)

Pre and post BPA

Interventions

Eligibility Criteria

You may qualify if:

You may not qualify if:

Sponsors & Collaborators

Study Sites (1)

MeSH Terms

Conditions

Condition Hierarchy (Ancestors)

Central Study Contacts

Study Design

Study Record Dates

Data Sharing

Source record

Locations