Motivational Behavioral and Functional MRI Impairment in Patients With Chronic Neuropathic Pain

NCT05701852 | Recruiting

• 1 other identifier: HBD_2022_6
• Study Type: observational
• Target: 50
• Locations: 1 country
• Sites: 1

Brief Summary

The main hypothesis of this study is that the alteration of the reward circuitry underlying the motivational deficit in chronic pain patients compared to healthy subjects results in a decrease in the capacity for reward learning. The fMRI studies have shown that this type of learning depends on the dopaminergic system innervating key regions of the reward system.

Conditions

Chronic Pain

Outcome Measures

Primary Outcomes (1)

• To compare reward learning ability in patients with chronic neuropathic pain compared with an age (±5 years) and gender-matched control population

  the reward learning ability will be assessed using a specific task. The result of the task questionnaire is a numeric score.

  Day 0

Study Arms (2)

cases : patients with chronic pain

Other: reward learning task

controls

Other: reward learning task

Interventions

reward learning task OTHER

during usual follow-up patients will complete a remard learning task questionnaire. This questionnaire cannot be assimilated to a clinical intervention.

cases : patients with chronic pain; controls

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

The study will be proposed to patients followed at the pain treatment center or in neurosurgery for chronic neuropathic pain, of peripheral or central origin. Controls will be recruited among the patients' companions and the staff of the Adolphe de Rothschild Foundation Hospital.

You may qualify if:

• For cases: patients managed in the neurosurgery department or at CETD for chronic neuropathic pain, of central or peripheral origin.
• For controls: matched to a case on age (±5 years) and sex

You may not qualify if:

• Neurodegenerative or inflammatory neurological pathology
• Clinical depressive syndrome
• High doses of opioid treatment (greater than 100 mg/day of morphine equivalent)
• Impaired judgment or inability to receive information that does not allow the performance of behavioral tasks
• Absolute contraindication to MRI (e.g. pacemaker, implantable pacemaker, metallic intra-orbital foreign body)

Sponsors & Collaborators

• Fondation Ophtalmologique Adolphe de Rothschild: lead

Study Sites (1)

Hôpital Fondation Adolphe de Rothschild

Paris, France

RECRUITING

MeSH Terms

Conditions

Chronic Pain

Condition Hierarchy (Ancestors)

Pain; Neurologic Manifestations; Signs and Symptoms; Pathological Conditions, Signs and Symptoms

Study Design

• Study Type: observational
• Observational Model: CASE CONTROL
• Time Perspective: CROSS SECTIONAL
• Sponsor Type: NETWORK
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: January 10, 2023
• First Posted: January 27, 2023
• Study Start: December 19, 2023
• Primary Completion (Estimated): May 1, 2027
• Study Completion (Estimated): May 1, 2027
• Last Updated: January 5, 2026

Record last verified: 2025-12

Data Sharing

• IPD Sharing: Will not share

Locations

FR (1)