NCT05686915

Brief Summary

Revision total hip replacement using a ceramic head utilizes a titanium sleeve which introduced another articulation into the system that may lead to a local soft tissue reaction. The purpose of this study is to determine the frequency, size and types of MRI documented local tissue reactions in individuals doing well after a revision total hip replacement and ceramic bearing surface that utilizes a titanium sleeve.

Trial Health

43
At Risk

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Trial has exceeded expected completion date
Enrollment
55

participants targeted

Target at P25-P50 for all trials

Timeline
Completed

Started Dec 2022

Shorter than P25 for all trials

Geographic Reach
1 country

1 active site

Status
unknown

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Start

First participant enrolled

December 22, 2022

Completed
15 days until next milestone

First Submitted

Initial submission to the registry

January 6, 2023

Completed
11 days until next milestone

First Posted

Study publicly available on registry

January 17, 2023

Completed
5 months until next milestone

Primary Completion

Last participant's last visit for primary outcome

June 1, 2023

Completed
7 months until next milestone

Study Completion

Last participant's last visit for all outcomes

December 31, 2023

Completed
Last Updated

January 17, 2023

Status Verified

January 1, 2023

Enrollment Period

5 months

First QC Date

January 6, 2023

Last Update Submit

January 13, 2023

Conditions

Keywords

RevisionTitanium Sleeve

Outcome Measures

Primary Outcomes (1)

  • MARS MRI abnormalities

    Local Tissue Reactions or Fluid collections on the MARS MRI Scan

    2 Years Post Revision Total Hip Replacement

Secondary Outcomes (3)

  • Titanium Lab Value

    2 Years Post Revision Total Hip Replacement

  • Chromium Lab Value

    2 Years Post Revision Total Hip Replacement

  • Cobalt Lab Value

    2 Years Post Revision Total Hip Replacement

Study Arms (1)

Revision Total Hip Arthroplasty

Patients who received a revision total hip surgery utilizing a ceramic femoral head with a titanium sleeve

Diagnostic Test: MARS MRIDiagnostic Test: Titanium LabsDiagnostic Test: Cobalt LabsDiagnostic Test: Chromium Labs

Interventions

MARS MRIDIAGNOSTIC_TEST

metal artifact reduction sequence (MARS) MRI to assess for fluid collections, ATLRs or other abnormalities

Revision Total Hip Arthroplasty
Titanium LabsDIAGNOSTIC_TEST

Labs to look at titanium levels in blood

Revision Total Hip Arthroplasty
Cobalt LabsDIAGNOSTIC_TEST

Labs to look at cobalt levels in blood

Revision Total Hip Arthroplasty
Chromium LabsDIAGNOSTIC_TEST

Labs to look at chromium levels in blood

Revision Total Hip Arthroplasty

Eligibility Criteria

Age18 Years - 99 Years
Sexall
Healthy VolunteersNo
Age GroupsAdult (18-64), Older Adult (65+)
Sampling MethodNon-Probability Sample
Study Population

Patients who received a revision total hip surgery utilizing a ceramic femoral head with a titanium sleeve

You may qualify if:

  • Patients who received a revision total hip surgery utilizing a ceramic femoral head with a titanium sleeve
  • Patient whose age ranges from 18-99
  • Patients who are not experiencing groin pain, thigh pain, or pain with ROM of the hip
  • Patients who are at least 2 years after a revision THA
  • Acetabular implant (cup) was placed in the appropriate position
  • Patients with a Harris Hip Score of \>90

You may not qualify if:

  • Patients who do not meet the above criteria
  • Patients unable to have an MRI (i.e. pacemaker, metal implants or issues with claustrophobia requiring sedation)

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

Colorado Joint Replacement

Denver, Colorado, 80210, United States

RECRUITING

Related Publications (1)

  • Fehring TK, Fehring K, Odum SM. Metal artifact reduction sequence MRI abnormalities occur in metal-on-polyethylene hips. Clin Orthop Relat Res. 2015 Feb;473(2):574-80. doi: 10.1007/s11999-014-3873-6.

    PMID: 25141843BACKGROUND

Study Officials

  • Jason M Jennings, MD

    Colorado Joint Replacement

    PRINCIPAL INVESTIGATOR

Central Study Contacts

Roseann M Johnson, BS, CCRP

CONTACT

Study Design

Study Type
observational
Observational Model
CASE ONLY
Time Perspective
PROSPECTIVE
Sponsor Type
OTHER
Responsible Party
PRINCIPAL INVESTIGATOR
PI Title
Orthopedic Surgeon

Study Record Dates

First Submitted

January 6, 2023

First Posted

January 17, 2023

Study Start

December 22, 2022

Primary Completion

June 1, 2023

Study Completion

December 31, 2023

Last Updated

January 17, 2023

Record last verified: 2023-01

Data Sharing

IPD Sharing
Will not share

Locations