Compensatory Kinematic Movements in Various Directions After Stroke

NCT05683158 | Completed Results

• 1 other identifier: Kinematic movements of stroke
• Study Type: observational
• Target: 96
• Locations: 1 country
• Sites: 1

Brief Summary

This is cross-sectional study. By comparing kinematic analysis between stroke and healthy subjects in various directions, this investigation analyzes the compensatory kinematic movement for reaching task in stroke survivors

Conditions

Cerebral Stroke; Hemiplegia, Spastic

Keywords

Chronic stroke; Reaching task; Motion capture

Outcome Measures

Primary Outcomes (7)

• Differences in Spatial Measurements of Trunk Dislocation Components During 3-directional Bell-reaching Task Between Healthy Subjects and Stroke Patients

  Trunk dislocation (reaching phase in millimetre; mm) in reaching task. The measurements are detected in 3 directions (Forward\_90, Lateral\_135, Medial\_45 degree). Participants reach to a bell as quickly as possible. 3rd joint is calculated for quantitative measurements.

  1 time (Baseline)

• Differences in Spatial Measurements of Elbow and Shoulder Angle Components During 3-directional Bell-reaching Task Between Healthy Subjects and Stroke Patients

  Elbow extension and shoulder flexion angle (degree) in reaching task. The measurements are detected in 3 directions (Forward\_90, Lateral\_135, Medial\_45 degree). Participants reach to a bell as quickly as possible. 3rd joint is calculated for quantitative measurements.

  1 time (Baseline)

• Differences in Temporal Measurements of Movement Unit Components During 3-directional Bell-reaching Task Between Healthy Subjects and Stroke Patients

  Movement units are quantified by counting velocity peaks during the reaching task. A movement unit is defined as a velocity profile segment between a local minimum and the following maximum velocity that exceeds 20 mm/s, with a minimum time interval of 150 ms between subsequent peaks. This measure represents the smoothness of movement, where fewer movement units indicate smoother motion The measurements are detected in 3 directions (Forward\_90, Lateral\_135, Medial\_45 degree). Participants reach to a bell as quickly as possible. 3rd joint is calculated for quantitative measurements.

  1 time (Baseline)

• Differences in Temporal Measurements of Hand Movement Time Components During 3-directional Bell-reaching Task Between Healthy Subjects and Stroke Patients

  The period from hand tangential velocity movement onset to offset was the total time (entire time of reach and return phase \[second\]). The period when the tangential velocity exceeded 10% of its peak was termed hand movement onset, whereas that when the tangential velocity stayed below 10% of its peak was termed hand movement offset. The measurements are detected in 3 directions (Forward\_90, Lateral\_135, Medial\_45 degree). Participants reach to a bell as quickly as possible. 3rd joint is calculated for quantitative measurements.

  1 time (Baseline)

• Differences in Temporal Measurements of Hand Velocity Components During 3-directional Bell-reaching Task Between Healthy Subjects and Stroke Patients

  Tangential velocity was computed for the hand marker's velocity. Peak elbow angular velocity (rad/s) during elbow extension were measured The measurements are detected in 3 directions (Forward\_90, Lateral\_135, Medial\_45 degree). Participants reach to a bell as quickly as possible. 3rd joint is calculated for quantitative measurements.

  1 time (Baseline)

• Differences in Temporal Measurements of Elbow Extension Acceleration Components During 3-directional Bell-reaching Task Between Healthy Subjects and Stroke Patients

  Acceleration (rad/s2) during elbow extension was measured The measurements are detected in 3 directions (Forward\_90, Lateral\_135, Medial\_45 degree). Participants reach to a bell as quickly as possible. 3rd joint is calculated for quantitative measurements.

  1 time (Baseline)

• Difference of the Components Temporal Measurements Between Healthy and Stroke

  Tangential velocity was computed for the hand marker's velocity. The period when the tangential velocity exceeded 10% of its peak was termed hand movement onset, whereas that when the tangential velocity stayed below 10% of its peak was termed hand movement offset. Peak hand velocity (mm/s) was analyzed. The measurements are detected in 3 directions (Forward\_90, Lateral\_135, Medial\_45 degree). Participants reach to a bell as quickly as possible. 3rd joint is calculated for quantitative measurements.

  1 time (Baseline)

Secondary Outcomes (1)

• Comparison of Fugl-Meyer Assessment Scores Between Chronic Stroke Patients and Healthy

  Baseline

Other Outcomes (6)

• Comparison of Modified Ashworth Scale Between Chronic Stroke Patients and Healthy Controls

  Baseline

• Range of motion_Health Status Chronic Stroke

  Baseline

• Trunk Impairment Scale(TIS)_Health Status Chronic Stroke

  1 time(Baseline)

Study Arms (2)

chronic stroke

The subject consisted of the physician's confirmation of chronic hemiplegia onset ≥ 6 months Mini-mental state examination≥25 Biceps ≤2, Triceps≤2 Ability to Sit on a chair alone FMA upper extremity score ≥ 21points, FMA upper extremity score ≤ 66 points The symptom is mild or moderate level (MAS≤2) and can sit alone. The subject reaches to target by affected arm in 3 directions(medial\_45, forward\_90 and lateral\_135 degrees)

Healthy

Matching aged people, not having neurological system or orthopedic disease on Upper extremity. The subject reaches to target by non-dominant arm in 3 directions(medial\_45, forward\_90 and lateral\_135 degrees)

Eligibility Criteria

• Age: 40 Years - 85 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Probability Sample

Study Population

Recruit research participants from the healthy group of 61 participants at the gym for the disabled of Ulsan city and Ulsan national institute of science and technology. Another group of 35 patients who enter the largest gym for the disabled of Ulsan city.

You may qualify if:

• Stroke
• Subject consisted of the physician's confirmation of chronic hemiplegia
• onset ≥ 6 months
• Mini-mental state examination≥25
• Biceps ≤2, Triceps≤2
• Ability to Sit on a chair alone
• FMA upper extremity score ≥ 21 points, FMA upper extremity ≤ 66 points
• Healthy
• Age of matching the stroke group
• Absence of neurological disease and orthopedic disease

You may not qualify if:

• Stroke
• Biceps\>2, Triceps\>2
• Flaccid
• Neglect syndrome
• Have neurological disease and orthopedic disease
• Lack of coordination

Sponsors & Collaborators

• University of Valencia: lead
• Ulsan National Institute of Science and Technology: collaborator

Study Sites (1)

Ulsan National Institute of Science and Technology

Ulsan, Ulju, 44919, South Korea

Location

Related Publications (13)

• Alt Murphy M, Murphy S, Persson HC, Bergstrom UB, Sunnerhagen KS. Kinematic Analysis Using 3D Motion Capture of Drinking Task in People With and Without Upper-extremity Impairments. J Vis Exp. 2018 Mar 28;(133):57228. doi: 10.3791/57228.

  PMID: 29658937 BACKGROUND

• Wu CY, Liing RJ, Chen HC, Chen CL, Lin KC. Arm and trunk movement kinematics during seated reaching within and beyond arm's length in people with stroke: a validity study. Phys Ther. 2014 Jun;94(6):845-56. doi: 10.2522/ptj.20130101. Epub 2014 Jan 30.

  PMID: 24481598 BACKGROUND

• Machado LR, Heathcock J, Carvalho RP, Pereira ND, Tudella E. Kinematic characteristics of arm and trunk when drinking from a glass in children with and without cerebral palsy. Clin Biomech (Bristol). 2019 Mar;63:201-206. doi: 10.1016/j.clinbiomech.2019.03.011. Epub 2019 Mar 19.

  PMID: 30925379 BACKGROUND

• Lobo-Prat J, Font-Llagunes JM, Gomez-Perez C, Medina-Casanovas J, Angulo-Barroso RM. New biomechanical model for clinical evaluation of the upper extremity motion in subjects with neurological disorders: an application case. Comput Methods Biomech Biomed Engin. 2014 Aug;17(10):1144-56. doi: 10.1080/10255842.2012.738199. Epub 2012 Nov 27.

  PMID: 23181596 BACKGROUND

• Hsieh YW, Liing RJ, Lin KC, Wu CY, Liou TH, Lin JC, Hung JW. Sequencing bilateral robot-assisted arm therapy and constraint-induced therapy improves reach to press and trunk kinematics in patients with stroke. J Neuroeng Rehabil. 2016 Mar 22;13:31. doi: 10.1186/s12984-016-0138-5.

  PMID: 27000446 BACKGROUND

• Cirstea MC, Levin MF. Compensatory strategies for reaching in stroke. Brain. 2000 May;123 ( Pt 5):940-53. doi: 10.1093/brain/123.5.940.

  PMID: 10775539 BACKGROUND

• Levin MF, Michaelsen SM, Cirstea CM, Roby-Brami A. Use of the trunk for reaching targets placed within and beyond the reach in adult hemiparesis. Exp Brain Res. 2002 Mar;143(2):171-80. doi: 10.1007/s00221-001-0976-6. Epub 2002 Jan 8.

  PMID: 11880893 BACKGROUND

• Adamovich SV, Archambault PS, Ghafouri M, Levin MF, Poizner H, Feldman AG. Hand trajectory invariance in reaching movements involving the trunk. Exp Brain Res. 2001 Jun;138(3):288-303. doi: 10.1007/s002210100694.

  PMID: 11460767 BACKGROUND

• Dean CM, Shepherd RB. Task-related training improves performance of seated reaching tasks after stroke. A randomized controlled trial. Stroke. 1997 Apr;28(4):722-8. doi: 10.1161/01.str.28.4.722.

  PMID: 9099186 BACKGROUND

• Dean C, Shepherd R, Adams R. Sitting balance I: trunk-arm coordination and the contribution of the lower limbs during self-paced reaching in sitting. Gait Posture. 1999 Oct;10(2):135-46. doi: 10.1016/s0966-6362(99)00026-0.

  PMID: 10502647 BACKGROUND

• Thrane G, Sunnerhagen KS, Murphy MA. Upper limb kinematics during the first year after stroke: the stroke arm longitudinal study at the University of Gothenburg (SALGOT). J Neuroeng Rehabil. 2020 Jun 15;17(1):76. doi: 10.1186/s12984-020-00705-2.

  PMID: 32539738 BACKGROUND

• Cirstea MC, Mitnitski AB, Feldman AG, Levin MF. Interjoint coordination dynamics during reaching in stroke. Exp Brain Res. 2003 Aug;151(3):289-300. doi: 10.1007/s00221-003-1438-0. Epub 2003 Jun 19.

  PMID: 12819841 BACKGROUND

• Schwarz A, Veerbeek JM, Held JPO, Buurke JH, Luft AR. Measures of Interjoint Coordination Post-stroke Across Different Upper Limb Movement Tasks. Front Bioeng Biotechnol. 2021 Jan 28;8:620805. doi: 10.3389/fbioe.2020.620805. eCollection 2020.

  PMID: 33585418 BACKGROUND

MeSH Terms

Conditions

Stroke; Hemiplegia

Condition Hierarchy (Ancestors)

Cerebrovascular Disorders; Brain Diseases; Central Nervous System Diseases; Nervous System Diseases; Vascular Diseases; Cardiovascular Diseases; Paralysis; Neurologic Manifestations; Signs and Symptoms; Pathological Conditions, Signs and Symptoms

Limitations and Caveats

the absence of randomization increased the risk of confounding bias.

Results Point of Contact

• Title: PI. Jose Casaña Granell
• Organization: Department of Physiotherapy, University of Valencia

jose.casana@uv.es

+34 656-437-371

Study Officials

• Jóse Casaña Granell, PhD

  University of Valencia

  PRINCIPAL INVESTIGATOR

• Joaquin Calatayud Villalba, PhD

  University of Valencia

  PRINCIPAL INVESTIGATOR

• Sang Hoon Kang, PhD

  Ulsan National Institute of Science and Technology

  PRINCIPAL INVESTIGATOR

Publication Agreements

• PI is Sponsor Employee: No
• Restrictive Agreement: No

Study Design

• Study Type: observational
• Observational Model: CASE CONTROL
• Time Perspective: CROSS SECTIONAL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Principal Investigator

Study Record Dates

• First Submitted: December 21, 2022
• First Posted: January 12, 2023
• Study Start: August 10, 2022
• Primary Completion: June 30, 2023
• Study Completion: July 10, 2023
• Last Updated: February 24, 2025
• Results First Posted: February 24, 2025

Record last verified: 2025-02

Data Sharing

• IPD Sharing: Will not share

Locations

KR (1)