The Relationship Between Driving Pressure, Mechanical Power, Oxygenation and Saturation Indices: Retrospective Observational Study

NCT05677165 | Completed

• 1 other identifier: 2021/293
• Study Type: observational
• Target: 361
• Locations: 1 country
• Sites: 1

Brief Summary

By using Mechanical Power and Driving Pressure instead of Pmean we calculate new oxygen saturation indices like Driving Pressure Oxygen Index (OIDP), Dynamic Power Oxygen Index (OIMPdyn), Total Power Oxygen Index (OIMPtot), Driving Pressure Saturation Index (OSIDP), Dynamic Power Saturation Index (OSIMPdyn) ve Power Saturation Index (OSIMPtot). New oxygenation and saturation indices are able to predict ICU mortality better than the conventional indexes and rates.

Conditions

Acute Respiratory Distress Syndrome; Pneumonia

Keywords

acute respiratory distress syndrome; pneumonia; oxygenation index; saturation index

Outcome Measures

Primary Outcomes (1)

• In hospital mortality

  we estimate hospital mortality mortality by calculating new oxygenation index

  28 days

Secondary Outcomes (1)

• Mechanical ventilatory free days

  30 days

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

The data of 784 patients with a diagnosis of Covid-19 hospitalized in the 28-bed intensive care unit of the Bakirkoy Dr. Sadi Konuk Training and Research Hospital were obtained by using structured query language (sql) queries from the 'ImdSoft-Metavision/QlinICU Clinical Decision Support (Israel) system'.173 patients who did not receive invasive mechanical ventilation support, 64 patients who stayed in the intensive care unit for less than 24 hours, 40 patients with missing data, and 38 patients who received mechanical ventilation support for less than 24 hours were excluded from the study.24 patients with COPD, 27 patients with congestive heart failure, and 11 patients who underwent tube thoracostomy due to tension pneumothorax were excluded from the study.In addition, 46 patients who received ECMO support were excluded from the study due to the possibility that ECMO may have an effect on respiratory variables. The remaining 361 patients were included in the study.

You may qualify if:

• \- Patients with a diagnosis of Covid-19 related Acute Respiratory Syndrome (C-ARDS) which hospitalized in Bakirköy Dr. Sadi Konuk Training and Research Hospital intensive care unit

You may not qualify if:

• Patients who did not receive invasive mechanical ventilation support.
• Patients who stayed in the intensive care unit for less than 24 hours.
• Patients with missing data
• Patients who received mechanical ventilation support for less than 24 hours
• Patients with Chronic Obstructive Pulmonary Disease (COPD).
• Patients with congestive heart failure
• Patients who underwent tube thoracostomy due to tension pneumothorax
• Patients who received Extracorporeal Membrane Oxygenation (ECMO) support

Sponsors & Collaborators

• Bakirkoy Dr. Sadi Konuk Research and Training Hospital: lead

Study Sites (1)

Bakirköy Dr sadi konuk Education hospital

Istanbul, Turkey (Türkiye)

Location

MeSH Terms

Conditions

Respiratory Distress Syndrome; Pneumonia

Condition Hierarchy (Ancestors)

Lung Diseases; Respiratory Tract Diseases; Respiration Disorders; Respiratory Tract Infections; Infections

Study Design

• Study Type: observational
• Observational Model: OTHER
• Time Perspective: RETROSPECTIVE
• Sponsor Type: OTHER GOV
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: November 21, 2022
• First Posted: January 10, 2023
• Study Start: March 18, 2020
• Primary Completion: November 1, 2021
• Study Completion: November 28, 2021
• Last Updated: January 10, 2023

Record last verified: 2022-12

Locations

TU (1)