Oral Processing and Appetite in Older Adults

NCT05671003 | Completed DMC

• 1 other identifier: UREC 22/29
• Study Type: observational
• Target: 88
• Locations: 1 country
• Sites: 1

Brief Summary

The goal of this observational study is to learn about changes in oral processing and appetite in older adults aged 65+ years old. The main question it aims to answer is if oral processing affects gastric emptying in older adults (≥65 years old).

Conditions

Older Adults; Appetitive Behaviour; Food Intake; Oral Processing

Keywords

older adults; appetite; oral processing; food intake; chewing; salivary flow; gastric emptying

Outcome Measures

Primary Outcomes (1)

• Objective appetite assessment: Ad-libitum meal consumption

  Consumption of the ad-libitum meal is measured (g). Participants are instructed to eat until they feel comfortable full

  During the procedure

Secondary Outcomes (10)

• Subjective appetite assessment: VAS

  During the procedure

• Gastric Emptying

  During the procedure

• Chewing rate

  During the procedure

• Salivary flow rate

  During the procedure

• BMI

  During the procedure

Eligibility Criteria

• Age: 65 Years+
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Healthy adults aged 65 years old or older

You may qualify if:

• years old or over (no upper age limit);each group will contain an equal number of male and female participants;
• living sufficiently local to attend the two visits needed;
• able to understand and communicate in English language.

You may not qualify if:

• Diagnosed dysphagia;
• (recent) oral surgery that significantly affects eating and/or swallowing;
• diagnosis of type 1 or type 2 diabetes;
• participant undergoing current treatment for cancer;
• participants with zero natural teeth;
• severe loss of appetite and not able to finish a meal (based on CNAQ) and/or people on special or therapeutic diets that restrict the consumption of a full meal and/or the meals provided;
• not able to provide informed consent as defined by the T-CogS test (participants with T-CogS \< 22 will be excluded);
• participants having a pacemaker;
• not able to accept the two meal dishes provided and/or relevant food/ingredient included in the meals allergies or intolerances or aversions;
• not able to feed themselves.

Sponsors & Collaborators

• University of Reading: lead
• University of Bern: collaborator
• Wageningen University: collaborator
• Queen's University, Belfast: collaborator

Study Sites (1)

University of Reading

Reading, United Kingdom

Location

Related Publications (4)

• Tada A, Miura H. Systematic review of the association of mastication with food and nutrient intake in the independent elderly. Arch Gerontol Geriatr. 2014 Nov-Dec;59(3):497-505. doi: 10.1016/j.archger.2014.08.005. Epub 2014 Aug 17.

  PMID: 25179444 BACKGROUND

• Pina GMS, Mota Carvalho R, Silva BSF, Almeida FT. Prevalence of hyposalivation in older people: A systematic review and meta-analysis. Gerodontology. 2020 Dec;37(4):317-331. doi: 10.1111/ger.12497. Epub 2020 Sep 23.

  PMID: 32965067 BACKGROUND

• Morley JE, Silver AJ. Anorexia in the elderly. Neurobiol Aging. 1988 Jan-Feb;9(1):9-16. doi: 10.1016/s0197-4580(88)80004-6.

  PMID: 2898107 BACKGROUND

• Krop EM, Hetherington MM, Nekitsing C, Miquel S, Postelnicu L, Sarkar A. Influence of oral processing on appetite and food intake - A systematic review and meta-analysis. Appetite. 2018 Jun 1;125:253-269. doi: 10.1016/j.appet.2018.01.018. Epub 2018 Feb 22.

  PMID: 29408331 BACKGROUND

Study Officials

• Miriam Clegg, BSc, PhD

  m.e.clegg@reading.ac.uk

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: CROSS SECTIONAL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Associate Professor

Study Record Dates

• First Submitted: December 15, 2022
• First Posted: January 4, 2023
• Study Start: January 15, 2023
• Primary Completion: September 15, 2023
• Study Completion: September 15, 2023
• Last Updated: July 5, 2024

Record last verified: 2024-07

Data Sharing

• IPD Sharing: Will not share

Locations

GB (1)