Cognitive Function Analysis and qEEG Study in Long COVID-19 Syndrome Patients

NCT05670418 | Unknown DMC

• 1 other identifier: 22-05-0578
• Study Type: observational
• Target: 45
• Locations: 1 country
• Sites: 1

Brief Summary

Over than 30% individuals with COVID-19, including the asymptomatic ones, and around 80% of patients hospitalized with COVID-19 may experience post-COVID sequelae, which is commonly referred to as Long COVID Syndrome. This condition has ties to decreased cognitive function and may lead to neuropsychiatric disorders but still need to be studied further. Using a cross-sectional design, this study will analyze the relationship between cognitive function and neuropsychiatric disorders with brain wave activity in Long COVID patients. The investigators conducted assessments utilizing the quantitative electroencephalogram (qEEG) measurement method and interviews using instruments such as the MOCA questionnaire and Self Rating Questionnaire (SRQ). With this qEEG examination, the investigators hoped that there will be an imbalance/abnormality of brain wave activity that arises related to impaired cognitive function.

Conditions

Long COVID-19 Syndrome

Keywords

Long COVID-19 Syndrome; COVID-19; Quantitative electroencephalography; Case-control study

Outcome Measures

Primary Outcomes (1)

• Cognitive Function

  Cognitive Function will be assessed using the qEEG, with an abnormality of brain wave activity, it indicates impairment of cognitive function

  Through study completion, an average of 1 year

Secondary Outcomes (2)

• Cognitive quality Assessed by MOCA

  Through study completion, an average of 1 year

• Self Rating Questionnaire (SRQ)

  Through study completion, an average of 1 year

Study Arms (2)

Long COVID-19

Patients post-COVID-19 with Long COVID-19 Syndrome

Device: Quantitative Electroencephalography

COVID-19

Patients post-COVID-19 without Long COVID-19 Syndrome

Device: Quantitative Electroencephalography

Interventions

Quantitative Electroencephalography DEVICE

Each qEEG examination of one person lasted about 20 minutes and included two stages: the first-recording of brain waves with eyes closed (5 min), the other with eyes open (5 min)

COVID-19; Long COVID-19

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

COVID-19 Patients

You may qualify if:

• Post-COVID-19 patients with Long COVID-19 Syndrome
• Over 18 years old
• Willing to participate in the research
• Completed the Montreal Cognitive Assessment (MoCA) and Self Rating Questionnaire (SRQ)

You may not qualify if:

• \. Patients with neuropsychiatric disorders before being infected with COVID-19

Sponsors & Collaborators

• Indonesia University: lead

Study Sites (1)

Rumah Sakit Cipto Manunkusumo

Jakarta Pusat, DKI Jakarta, 10430, Indonesia

RECRUITING

MeSH Terms

Conditions

Post-Acute COVID-19 Syndrome; COVID-19

Condition Hierarchy (Ancestors)

Pneumonia, Viral; Pneumonia; Respiratory Tract Infections; Infections; Virus Diseases; Coronavirus Infections; Coronaviridae Infections; Nidovirales Infections; RNA Virus Infections; Lung Diseases; Respiratory Tract Diseases; Post-Infectious Disorders; Chronic Disease; Disease Attributes; Pathologic Processes; Pathological Conditions, Signs and Symptoms

Central Study Contacts

Yetty Ramli, MD

CONTACT

+62811163843; yettyramli@gmail.com

Dyah Tunjungsari, MD

CONTACT

+628119884224; penelitian.neuroui@gmail.com

Study Design

• Study Type: observational
• Observational Model: CASE CONTROL
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Medical Staff & Lecturer

Study Record Dates

• First Submitted: November 22, 2022
• First Posted: January 4, 2023
• Study Start: October 1, 2022
• Primary Completion: December 30, 2023
• Study Completion: December 30, 2023
• Last Updated: November 18, 2023

Record last verified: 2023-11

Locations

ID (1)