NCT05665010|Unknown
Loading search results
Sponsor study identifier
observational
1,000
1 country
18
Study Start
November 1, 2021
Actual (reported)Primary Completion
October 31, 2023
Estimated (date passed)This estimate has passed. The registry has not confirmed an actual date for this milestone.
Study Completion
October 31, 2024
Estimated (date passed)This estimate has passed. The registry has not confirmed an actual date for this milestone.
Aging is a common problem in human society at present. The fertility decline, perimenopausal symptoms and senile diseases caused by ovarian aging seriously affect women's own health, offspring's health, family and social stability, and endanger national population security. Accurate stratification of genetic risk of ovarian aging has practical significance. Early and accurate identification of high-risk groups of premature ovarian aging can help such women to start early protection of ovarian function, preserve fertility to a greater extent, improve fertility quality, and also be conducive to early prevention and treatment of other systemic diseases and prognosis.
Registry-reported information. Elapsed time and enrollment totals alone do not measure study progress or recruitment pace.
October 31, 2024
Estimated (date passed)This estimate has passed. The registry has not confirmed an actual date for this milestone.
Click on a node to explore related trials.
Some registry-reported names shown below are not yet linked in this graph.
Dates and qualifiers reported by the registry. Estimated dates do not confirm that a milestone has occurred.
November 1, 2021
Actual (reported)November 30, 2022
Actual (reported)December 27, 2022
Actual (reported)October 31, 2023
Estimated (date passed)This estimate has passed. The registry has not confirmed an actual date for this milestone.
October 31, 2024
Estimated (date passed)This estimate has passed. The registry has not confirmed an actual date for this milestone.
Genetic variants
Genetic variants that differed significantly between participants and the general population
2 year
Menopause age
One year after the last menstruation
Patients with premature ovarian insufficiency (female age \<40 years, menopause or menstrual rarity for 4 months, basal FSH \> 25 IU / L for two consecutive intervals of more than 4 weeks)
Patients with diminished ovarian reserve(women before 40 years old; the number of antral follicles in both ovaries is less than 6, AMH \< 1.1ng/ml, and basal FSH \> 10 IU / L, which meets one of the three requirements)；Female with menopause between the age of 40 and 45.
Genetic susceptibility increases the risk of ovarian injury
Registry-reported names are shown in full. Names without a link have not yet been matched to a Syfrah profile.
A multi regional ovarian aging cohort of Chinese population, including 500 patients with premature ovarian insufficiency, 500 patients with diminished ovarian reserve or early menopause.
Fujian maternal and Child Health Hospital
Fuzhou, Fujian, China
Guangdong maternal and Child Health Hospital
Guangzhou, Guangdong, China
Guangdong Provincial People's Hospital
Guanzhou, Guangdong, China
Ma W, Ye S, Tian L, Liu M, Wang R, Yang X, Wang M, Fu F, Ren W, Dang L, Wang T, Wang W, Wang S, Sun Y, Li Y. Association of LHCGR rs2293275 genotype with ovarian aging in Chinese women: a multicenter population-based study. Reprod Biol Endocrinol. 2025 Mar 15;23(1):41. doi: 10.1186/s12958-025-01375-2.
Shixuan Wang, Doctor
Tongji Hospital
First Submitted
November 30, 2022
First Posted
December 27, 2022
Study Start
November 1, 2021
Actual (reported)Primary Completion
October 31, 2023
Estimated (date passed)Contact the study team to confirm eligibility.
Shijiazhuang maternity hospital
Shijiazhuang, Hebei, China
The Third Affiliated Hospital of Zhengzhou University
Zhengzhou, Henan, China
Tongji Hospital Affiliated to Tongji Medical College of Huazhong University of science and technology
Wuhan, Hubei, 430000, China
Central South Hospital of Wuhan University
Wuhan, Hubei, China
Hubei maternal and Child Health Hospital
Wuhan, Hubei, China
Liyuan Hospital Affiliated to Tongji Medical College of Huazhong University of science and technology
Wuhan, Hubei, China
People's Hospital of Wuhan University
Wuhan, Hubei, China
Xiangyang Central Hospital
Xiangyang, Hubei, China
Changsha maternal and Child Health Hospital
Changsha, Hunan, China
The First Affiliated Hospital of Suzhou University
Suzhou, Jiangsu, China
Jiangxi maternal and Child Health Hospital
Nanchang, Jiangxi, China
Northwest women and children's Hospital
Xi’an, Shanxi, China
The First Affiliated Hospital of Xi'an Jiaotong University
Xi’an, Shanxi, China
Affiliated Hospital of Yunnan University
Kunming, Yunnan, China
Hospital of Obstetrics and Gynecology affiliated to Medical College of Zhejiang University
Hangzhou, Zhejiang, China
This estimate has passed. The registry has not confirmed an actual date for this milestone.
Study Completion
October 31, 2024
Estimated (date passed)This estimate has passed. The registry has not confirmed an actual date for this milestone.
Last Updated
December 27, 2022
Record last verified: 2022-12
Download the complete ClinicalTrials.gov record imported by Syfrah, including fields not shown in this page. The registry may contain a newer revision.
Source: ClinicalTrials.gov.
JSON downloads include source attribution and retrieval details alongside the unchanged original record or the separately normalized values.
Source retrieved: