Prospective Study and Analysis of Biomechanical Parameters of Human Movement Based on Disability Indicators in Older Adults

NCT05656690 | Completed

• 3 other identifiers: CE0077C2020.05356.BDUIDB/05210/2020
• Study Type: observational
• Target: 60
• Locations: 1 country
• Sites: 1

Brief Summary

Mobility loss in older people is caused by a variety of aging impairments in various body systems.The disability, which includes physical impairments and resulting activity limitations or participation restrictions, can arise acutely from a catastrophic illness or, more commonly, from subacute functional decline without a clear triggering event. Lower physical functioning was associated with higher healthcare utilization and expenditures, leading to a large burden on government-funded healthcare services. Early identification of mobility changes and intervening in them would likely be the most effective strategy to reduce the burden of disability in the population. Overall, there is a need to develop strategies to reduce disability among older adults in which kinetic and kinematic characteristics are used to predict disability status. Accordingly, the purpose of this prospective cohort is to identify biomechanical parameters, from the gait, sit-to-stand, timed up and go, stair ascend and descend, and quiet standing functional tasks, as predictors of changes in health and disability status in older adults. This research was funded by Fundação para a Ciência e Tecnologia (FCT), NORTE 2020, and European Social Fund of European Union, grant number 2020.05356.BD and through R\&D Units funding (UIDB/05210/2020), Fundação para a Ciência e Tecnologia (FCT), Portugal and the European Union.

Conditions

Disability

Outcome Measures

Primary Outcomes (15)

• Waveforms from full-body joint angles

  Waveforms from full-body joint angles measured in degrees (°)

  Assessed once at study entry.

• Waveform from full-body angular joint velocities

  Waveform from angular joint velocities measured in degrees per second (°/s)

  Assessed once at study entry

• Waveform from lower limb joint moments

  Waveform from lower limb joint moments measured in Newton-meter (kgm²/s²)

  Assessed once at study entry

• Waveform from total body energy

  Waveform from total body energy measured in joules (J)

  Assessed once at study entry

• Waveform from full-body separate segment energy

  Waveform from body segment energy un joules (J)

  Assessed once at study entry

• Waveform from lower body joint forces

  Waveform from lower body joint forces measured in Newton (N)

  Assessed once at study entry

• Waveform from lower body joint power

  Waveform from lower body joint power measured in Watts

  Assessed once at study entry

• Waveform from centre of mass displacement

  Waveform from centre of mass displacement in m/s

  Assessed once at study entry

• Waveform from centre of pressure displacement

  Waveform from centre of pressure displacement in m/s

  Assessed once at study entry

• International Physical Activity Questionnaire

  IPAQ is questionnaire to assess self-reported physical activity

  Assessed at study entry and evaluated every three months until the end of 1 year

• Mini-Mental State Examination (MMSE)

  MMSE provides a brief screening test that quantitatively assesses the severity of cognitive impairment and documents cognitive changes occurring over time

  Assessed at study entry and evaluated every three months until the end of 1 year

• Barthel Index

  The Barthel Index is an instrument that assesses the individual's level of independence for ten activities of daily living

  Assessed at study entry and evaluated every three months until the end of 1 year

• Lawton and Brody Instrumental Activities of Daily Living Scale

  Lawton and Brody Instrumental Activities of Daily Living Scale assess the instrumental ADLs necessary for living in the community

  Assessed at study entry and evaluated every three months until the end of 1 year

• Number of health conditions

  Total number and description of health conditions

  Assessed at study entry and evaluated every three months until the end of 1 year

• Number of falls

  Total number and description of ocurrences of falls

  Assessed at study entry and evaluated every three months until the end of 1 year

Study Arms (2)

Healthy older Adults

Healthy older Adults: older adults without disability indicators

Other: Exposure to disability

Disability Older Adults

Disability Older Adults: older adults with disability indicators

Other: Exposure to disability

Interventions

Exposure to disability OTHER

Disability status assessed by functional measures

Disability Older Adults; Healthy older Adults

Eligibility Criteria

• Age: 60 Years+
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Portuguese community-dwelling older adults

You may qualify if:

• older adults, 60 years or over;
• community-dwelling;
• able to perform the tasks (gait, sit-to-stand, climb and descend stairs) independently;

You may not qualify if:

• older adults who are institutionalized;
• older adults who have established diagnosis of malignancy or terminal diseases with an anticipated survival of less than 1 year;
• older adults who have stroke history, cerebral hemorrhage, head trauma, or Parkinson's disease;
• older adults who have cognitive impairment, specifically Mini Mental StateExamination (Portuguese version) score of 22 for 0 to 2 years of literacy, 24 for 3 to6 years of literacy and 27 for more than 6 years of literacy (Morgado et al., 2009);
• older adults who have rheumatic pathologies that interfere with the tasks performance;
• older adults who have diabetic foot, lower limb fracture less than 6 weeks, or other related conditions;
• older adults who have unstable cardiovascular disease, liver or renal function failure;
• older adults who have a body mass index greater than or equal to 30 kg/m2;
• older adults who vestibular and/or audition or vision impairments non corrected that influence the performance of tasks;
• older adults who presence of symptoms at the time of evaluation that influences the participant performance of tasks.

Sponsors & Collaborators

• Polytechnic Institute of Porto: lead
• Center for Rehabilitation Research - Polytechnic Institute of Porto (IPP): collaborator
• Universidade do Porto: collaborator
• School of Allied Health Sciences of Porto (ESTSP) - Polytechnic Institute of Porto (IPP): collaborator

Study Sites (1)

Center for Rehabilitation Research, School of Health, Polytechnic of Porto, Portugal

Porto, 4200, Portugal

Location

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: PhD grant student

Study Record Dates

• First Submitted: November 18, 2022
• First Posted: December 19, 2022
• Study Start: May 1, 2022
• Primary Completion: July 31, 2024
• Study Completion: July 31, 2024
• Last Updated: November 7, 2024

Record last verified: 2024-11

Locations

PT (1)