Hibiscus Sabdariffa Extract Effect on Neuromuscular Performance

NCT05653076 | Unknown

• 1 other identifier: 1364-N-22
• Study Type: interventional
• Target: 25
• Locations: 1 country
• Sites: 2

Brief Summary

Exercise-induced muscle damage (EIMD) is a transient problem that athletes face after performing more intense and/or prolonged exercise than they are used to. EIMD is accompanied by an increase in the production of reactive oxygen species and a decrease in the antioxidant capacity of the organism. This phenomenon decreases the performance capacity of athletes due to impaired muscle strength and range of motion. Among the strategies to reduce EIMD, the use of nutritional strategies rich in antioxidants such as polyphenols stands out. In this sense, the extract of Hibiscus sabdariffa is particularly rich in polyphenolic antioxidants, among which anthocyanins stand out. Previous studies have concluded that the administration of an extract of Hibiscus sabdariffa can prevent overtraining syndrome by reducing the levels of oxidizing agents and increasing the body's antioxidant defenses. However, despite the fact that Hibiscus sabdariffa extract has been shown to be safe for humans to ingest and have various health benefits, to our knowledge, no studies have evaluated its ability to minimize neuromuscular performance impairment that occurs after performing an intense session of strength training. Based on previous evidence, we hypothesize that supplementation with an extract of Hibiscus sabdariffa will improve neuromuscular performance after performing intense resistance exercise in young (18-35 years) and trained adults, with at least 1 year of experience training. strength. The design of this study is crossover, randomized and placebo controlled, where each individual will act as her own control. The neuromuscular performance parameters to be evaluated will be: i) explosive strength - main variable, in terms of countermovement jump height (CMJ); ii) the maximum dynamic force; and iii) the ability to change direction, all of them 24h and 72h after a high-intensity strength training session. If our hypothesis is confirmed, the results of our study would not only have an impact at a scientific level but also at a commercial level through the development of supplements and/or functional foods.

Conditions

Neuromuscular Performance

Keywords

nutritional ergogenics; sport supplementation; anthocyanins; polyphenols; antioxidants; strength

Outcome Measures

Primary Outcomes (3)

• Explosive strength

  It will be measured through the height of the countermovement jump (CMJ)

  1 day (24h) after a bout of an intense resistance exercise

• Maximal dynamic force

  It will be measured by means of a CMJ with a load

  1 day (24h) after a bout of an intense resistance exercise

• Ability to change direction

  It will be measured by means of a CMJ with a load

  1 day (24h) after a bout of an intense resistance exercise

Secondary Outcomes (3)

• Explosive strength

  3 days (72h) after a bout of an intense resistance exercise

• Maximal dynamic force

  3 days (72h) after a bout of an intense resistance exercise

• Ability to change direction

  3 days (72h) after a bout of an intense resistance exercise

Study Arms (2)

Placebo

PLACEBO COMPARATOR

Microcrystalline cellulose

Dietary Supplement: Hibiscus sabdariffa extract

Hibiscus sabdariffa extract

EXPERIMENTAL

520 mg of Hibiscus sabdariffa extract

Dietary Supplement: Hibiscus sabdariffa extract

Interventions

Hibiscus sabdariffa extract DIETARY_SUPPLEMENT

Daily supplementation with 520 mg of Hibiscus sabdariffa extract for 10 days.

Hibiscus sabdariffa extract; Placebo

Eligibility Criteria

• Age: 18 Years - 35 Years
• Sex: male
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)

You may qualify if:

• Age: 18-35 years.
• Body mass index: 18.5-30 kg/m2
• Be able to understand the instructions, objectives, and protocol of the study.
• Trained in some force sports discipline ≥1 year prior to the study and accustomed to carrying out the exercises of the evaluation protocol.

You may not qualify if:

• History of a major adverse cardiovascular event, renal failure, cirrhosis, eating disorder, polycystic ovarian syndrome, weight control surgery, type 2 diabetes mellitus, or HIV/AIDS.
• Any chronic pathology in which the intake of nutritional supplements is not recommended.
• Any condition that, in the investigator's judgment, impairs the ability to participate in the study or represents a personal risk to the participant.
• Use of medications that may affect the results of the study.
• Unstable body weight for 3 months prior to study start (\>4 kg weight gain or loss)
• Routine use of teas/infusions/supplements rich in polyphenols.
• Pregnancy and lactation.
• Active tobacco or illicit drug use or history of treatment for alcohol abuse.
• To be on a special diet or prescribed for other reasons (eg celiac disease).

Sponsors & Collaborators

• Universidad de Granada: lead

Study Sites (2)

Instituto Mixto Universitario Deporte y Salud (iMUDS)

Granada, 18007, Spain

RECRUITING

Facultad de Ciencias del Deporte

Granada, 18071, Spain

RECRUITING

Central Study Contacts

Francisco J Osuna-Prieto, PhD

CONTACT

+34 618117577; fjosunaprieto@ugr.es

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: TRIPLE
• Who Masked: PARTICIPANT, INVESTIGATOR, OUTCOMES ASSESSOR
• Masking Details: triple-blinded
• Purpose: PREVENTION
• Intervention Model: CROSSOVER
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Principal Investigator

Study Record Dates

• First Submitted: November 28, 2022
• First Posted: December 16, 2022
• Study Start: January 23, 2023
• Primary Completion: April 1, 2023
• Study Completion: June 1, 2023
• Last Updated: January 26, 2023

Record last verified: 2023-01

Data Sharing

• IPD Sharing: Will not share

Locations

ES (2)