NCT05183893

Brief Summary

The main aim of this study is to compare the effects of L-Citrulline vs. Citrulline-malate on neuromuscular performance (maximal dynamic strength and maximal endurance strength) in resistance-trained adults.

Trial Health

87
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
50

participants targeted

Target at P25-P50 for not_applicable

Timeline
Completed

Started Feb 2022

Shorter than P25 for not_applicable

Geographic Reach
1 country

1 active site

Status
completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

First Submitted

Initial submission to the registry

December 21, 2021

Completed
21 days until next milestone

First Posted

Study publicly available on registry

January 11, 2022

Completed
1 month until next milestone

Study Start

First participant enrolled

February 15, 2022

Completed
5 months until next milestone

Primary Completion

Last participant's last visit for primary outcome

June 30, 2022

Completed
Same day until next milestone

Study Completion

Last participant's last visit for all outcomes

June 30, 2022

Completed
Last Updated

November 4, 2022

Status Verified

November 1, 2022

Enrollment Period

5 months

First QC Date

December 21, 2021

Last Update Submit

November 3, 2022

Conditions

Neuromuscular Performance

Keywords

nitric oxidedietary supplementresistance trainingcitrulline malate

Outcome Measures

Primary Outcomes (1)

  • Maximal endurance strength

    Maximal endurance strength of lower- and upper-body (squat and bench press exercises)

    1 hour

Secondary Outcomes (1)

  • Maximal dynamic strength

    1 hour

Study Arms (3)

Experimental: L-Citrulline

EXPERIMENTAL

5 g of L-citruline + 5 g of additives. The dose to be administered is that recommended on the labeling and nutritional information of the product, which has been produced under GMP procedures and approved by the EFSA (Lifepro®).

Dietary Supplement: L-citrulline

Experimental: Citrulline-malate

EXPERIMENTAL

8g of citrulline-malate + 2 g of additives. The dose to be administered is that recommended on the labeling and nutritional information of the products which has been produced under GMP procedures and approved by the EFSA (Lifepro®).

Dietary Supplement: Citrulline-malate

Placebo

PLACEBO COMPARATOR

10g of maltodextrin plus additives (Lifepro®).

Dietary Supplement: Placebo

Interventions

L-citrullineDIETARY_SUPPLEMENT

5 g of L-citruline + 5 g of additives

Experimental: L-Citrulline
Citrulline-malateDIETARY_SUPPLEMENT

8g of citrulline-malate + 2 g of additives

Experimental: Citrulline-malate
PlaceboDIETARY_SUPPLEMENT

10g of maltodextrine

Placebo

Eligibility Criteria

Age18 Years - 35 Years
Sexall
Healthy VolunteersYes
Age GroupsAdult (18-64)

You may qualify if:

  • Healthy male or female
  • Ages 18-30years
  • BMI: 18-30.0 kg/m2
  • Stable weight over the last 3 months (body weight changes\<3kg)
  • Previous experience in resistance training (i.e., at least 1 year with a frequency of two or more training sessions per week),

You may not qualify if:

  • History of chronic diseases (renal disease, diabetes, cardiovascular disease, cancer, VIH, hepatic disease, food disorders)
  • Pregnant, planning to become pregnant, or breastfeeding
  • Have been treated previously or during the study period with prescription drugs:
  • antihypertensive, lipid lowering, acid uric lowering, glucose lowering, beta blockers or any drug that under the investigator's judged could influence the results.
  • Allergy/intolerance to any ingredient of the dietary supplements.
  • Chronic consumers of dietary NO-precursors dietary supplements (citrulline malate, arginine, nitrates).
  • Any non-controlled medical condition which could influence results or could be worsened by the participation in the study.
  • Are deemed unsuitable by the investigator for any other reason, that prevent data collection.

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

Jonatan Ruiz Ruiz

Granada, 18011, Spain

Location

Related Publications (1)

  • Martin-Olmedo JJ, Miras-Moreno S, Cuadra-Montes K, Garcia-Ramos A, Ruiz JR, Jurado-Fasoli L. Malate or Not? Acute Effects of L-Citrulline Versus Citrulline Malate on Neuromuscular Performance in Young, Trained Adults: A Randomized, Double-Blind, Placebo-Controlled Crossover Trial. Int J Sport Nutr Exerc Metab. 2024 Dec 11;35(2):89-98. doi: 10.1123/ijsnem.2024-0006. Print 2025 Mar 1.

    PMID: 39662304DERIVED

MeSH Terms

Interventions

Citrullinecitrulline malate

Intervention Hierarchy (Ancestors)

Amino Acids, DiaminoAmino AcidsAmino Acids, Peptides, and Proteins

Study Design

Study Type
interventional
Phase
not applicable
Allocation
RANDOMIZED
Masking
QUADRUPLE
Who Masked
PARTICIPANT, CARE PROVIDER, INVESTIGATOR, OUTCOMES ASSESSOR
Purpose
OTHER
Intervention Model
CROSSOVER
Sponsor Type
OTHER
Responsible Party
PRINCIPAL INVESTIGATOR
PI Title
Researcher

Study Record Dates

First Submitted

December 21, 2021

First Posted

January 11, 2022

Study Start

February 15, 2022

Primary Completion

June 30, 2022

Study Completion

June 30, 2022

Last Updated

November 4, 2022

Record last verified: 2022-11

Locations

ES(1)