Comparison of Superficial+Deep Vs. Deep Serratus Anterior Plan Block in Video-Assisted Thoracic Surgery

NCT05852561 | Completed

• 1 other identifier: ataunivatsanalgesia
• Study Type: interventional
• Target: 60
• Locations: 1 country
• Sites: 1

Brief Summary

Thoracotomy is one of the most painful surgeries; Video-assisted thoracoscopic surgery (VATS) has been developed to reduce the surgical stress of thoracotomy. However, patients may experience moderate to severe pain within the first 24 hours after VATS. Intravenous opioids are frequently used to provide postoperative analgesia, and accordingly, side effects such as postoperative nausea/vomiting and respiratory depression can be seen. The aim of this study is to compare Superficial+Deep Vs. Deep Serratus Anterior Plan Block for postoperative pain control in VATS cases.

Conditions

Analgesia

Outcome Measures

Primary Outcomes (1)

• Postoperative opioid consumption

  First 24 hours total fentanyl consumption with patient controlled analgesia

  first 24 hours

Secondary Outcomes (1)

• Visual analog pain score

  first 48 hours

Study Arms (2)

Group Superficial+Deep Serratus Anterior Plan Block

ACTIVE COMPARATOR

Superficial+Deep Serratus Anterior Plan Block after Video-Assisted Thoracic Surgery

Other: Group Superficial+Deep Serratus Anterior Plan Block

Group Deep Serratus Anterior Plan Block

ACTIVE COMPARATOR

Deep Serratus Anterior Plan Block after Video-Assisted Thoracic Surgery

Other: Group Deep Serratus Anterior Plan Block

Interventions

Group Superficial+Deep Serratus Anterior Plan Block OTHER

The block will be performed after induction of general anesthesia and surgical positioning. 15 ml of 0.375% Bupivacaine + epinephrine 5 µg/ml will be administered between the serratus anterior and latissimus dorsalis muscles. The same concentration of block fluid will be applied between the serratus anterior and the outer intercostal muscle.

Group Superficial+Deep Serratus Anterior Plan Block

Group Deep Serratus Anterior Plan Block OTHER

30 ml 0.375% Bupivacaine + epinephrine 5 µg/ml will be administered between the serratus anterior and outer intercostal muscle.

Group Deep Serratus Anterior Plan Block

Eligibility Criteria

• Age: 18 Years - 65 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• American Society of Anesthesiologist's physiologic state I-III patients
• To undergo Video Assisted Thoracic Surgery
• Being between the ages of 18-65 years

You may not qualify if:

• having a known heart, kidney, liver or hematological disease
• having a history of peptic ulcer, gastrointestinal bleeding, allergy, chronic pain
• Routine analgesic use and history of analgesic use in the last 24 hours
• Not willingto participate in the study
• Uncooperative patients who have coagulopathy or use anticoagulant drugs
• To be allergic to one of the drugs to be used
• Contraindication for Video Assisted Thoracic Surgery

Sponsors & Collaborators

• Ataturk University: lead

Study Sites (1)

Ali Ahiskalioglu

Erzurum, 25100, Turkey (Türkiye)

Location

Related Publications (2)

• Lee J, Kim S. The effects of ultrasound-guided serratus plane block, in combination with general anesthesia, on intraoperative opioid consumption, emergence time, and hemodynamic stability during video-assisted thoracoscopic lobectomy: A randomized prospective study. Medicine (Baltimore). 2019 May;98(18):e15385. doi: 10.1097/MD.0000000000015385.

  PMID: 31045789 BACKGROUND

• Qiu L, Bu X, Shen J, Li M, Yang L, Xu Q, Chen Y, Yang J. Observation of the analgesic effect of superficial or deep anterior serratus plane block on patients undergoing thoracoscopic lobectomy. Medicine (Baltimore). 2021 Jan 22;100(3):e24352. doi: 10.1097/MD.0000000000024352.

  PMID: 33546068 BACKGROUND

MeSH Terms

Conditions

Agnosia

Condition Hierarchy (Ancestors)

Perceptual Disorders; Neurobehavioral Manifestations; Neurologic Manifestations; Nervous System Diseases; Signs and Symptoms; Pathological Conditions, Signs and Symptoms

Study Officials

• Elif Oral Ahiskalioglu

  Ataturk University

  STUDY DIRECTOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: TRIPLE
• Who Masked: PARTICIPANT, INVESTIGATOR, OUTCOMES ASSESSOR
• Purpose: TREATMENT
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Principal Investigator

Study Record Dates

• First Submitted: May 2, 2023
• First Posted: May 10, 2023
• Study Start: May 15, 2023
• Primary Completion: November 15, 2023
• Study Completion: December 15, 2023
• Last Updated: April 16, 2024

Record last verified: 2024-04

Locations

TU (1)