Severe Acute Respiratory Infections (SARI) in Belgium (2011-2020)

NCT05620953 | Completed

• 1 other identifier: SARI-11-20
• Study Type: observational
• Target: 12,145
• Locations: 0 countries
• Sites: N/A

Brief Summary

The Belgian Severe Acute Respiratory Infections network (BELSARI-net) was implemented during the influenza season 2011-2012 following the recommendations of the World Health Organization (WHO) to monitor severity of influenza viruses in hospitals. The network is composed of 6 hospitals throughout the country, two in each administrative region (Flanders, Wallonia and Brussels-Capital), and operates during the influenza epidemic period (from the last week of December or first/second week of January to the third/last week of April, depending on when influenza virus circulation is detected by the general population, based on the Influenza-like illness (ILI) network of general practitioners). Enrollment is performed for all cases matching the SARI case definition (based on WHO's case definition) and accepting to take part. A respiratory specimen is sampled systematically from each participant, and detailed clinico-epidemiological data, such as information on age, sex, symptoms and potential risk factors such as pregnancy or comorbidities (chronic respiratory diseases, asthma, chronic cardiovascular diseases, renal insufficiency, obesity, diabetes, hepatic or renal insufficiency, immunodeficiency, neuromuscular disease, pregnancy) is also collected. Participants are followed up during hospitalization for the occurrence of complications (detection of pneumonia based on chest radiography, development of acute respiratory distress syndrome (ARDS), requirement for respiratory assistance and/or for extracorporeal membrane oxygenation (ECMO), admission in intensive care unit (ICU)), or death (all-cause death). The current project includes all the samples received by the Belgian National Influenza Centre (NIC) during the influenza seasons 2011-2012 till 2019-2020.

Conditions

Influenza Viral Infections; Respiratory Viral Infection; Severe Acute Respiratory Infection

Keywords

sentinel surveillance

Outcome Measures

Primary Outcomes (3)

• Number of participants positive for influenza viruses

  result of influenza PCR detection test (typing and subtyping)

  within 10 days after symptom onset

• Number of participants positive for non-influenza viruses

  results of non-influenza multiplex PCR detection test (16 targets)

  within 10 days after symptom onset (only routinely tested since influenza season 2015-2016)

• Number of participants who died during hospitalization

  alive or dead

  from date of hospital admission until date of death during hospitalization or date of hospital exit

Secondary Outcomes (2)

• Number of participants with at least one known risk factor

  on date of hospital admission

• Number of participants who experienced at least one complication

  from date of hospital admission until date of death during hospitalization or date of hospital exit

Study Arms (1)

SARI case

Diagnostic Test: respiratory specimen

Interventions

respiratory specimen DIAGNOSTIC_TEST

nasopharyngeal swab or nasal aspiration or broncho-alveolar lavage

SARI case

Eligibility Criteria

• Sex: all
• Healthy Volunteers: No
• Age Groups: Child (0-17), Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Patients admitted to one of the 6 participating hospital during the season surveillance dates.

You may qualify if:

• All pediatric and adult patients admitted to one of the 6 sentinel hospitals during the active surveillance and fulfilling the case definition of acute respiratory infection with onset within the last ten days, with history of fever or measured fever of ≥38°C, with cough and/or dyspnea, and overnight hospitalization.

You may not qualify if:

• nosocomial infection, i.e. symptoms appearing after admission

Sponsors & Collaborators

• Sciensano: lead
• Belgian Federal Public Service, Food Chain Safety and Environment: collaborator
• Centre Hospitalier Universitaire Saint Pierre: collaborator
• AZ Sint-Jan AV: collaborator
• Universitair Ziekenhuis Brussel: collaborator
• Grand Hôpital de Charleroi: collaborator
• Jessa Hospital: collaborator
• Centre Hospitalier Universitaire UCLouvain Namur: collaborator

Related Publications (4)

• Subissi L, Bossuyt N, Reynders M, Gerard M, Dauby N, Lacor P, Daelemans S, Lissoir B, Holemans X, Magerman K, Jouck D, Bourgeois M, Delaere B, Quoilin S, Van Gucht S, Thomas I, Barbezange C. Spotlight influenza: Extending influenza surveillance to detect non-influenza respiratory viruses of public health relevance: analysis of surveillance data, Belgium, 2015 to 2019. Euro Surveill. 2021 Sep;26(38):2001104. doi: 10.2807/1560-7917.ES.2021.26.38.2001104.

  PMID: 34558405 RESULT

• Fischer N, Dauby N, Bossuyt N, Reynders M, Gerard M, Lacor P, Daelemans S, Lissoir B, Holemans X, Magerman K, Jouck D, Bourgeois M, Delaere B, Quoilin S, Van Gucht S, Thomas I, Barbezange C, Subissi L. Monitoring of human coronaviruses in Belgian primary care and hospitals, 2015-20: a surveillance study. Lancet Microbe. 2021 Mar;2(3):e105-e114. doi: 10.1016/S2666-5247(20)30221-4. Epub 2021 Jan 27.

  PMID: 33937883 RESULT

• Subissi L, Bossuyt N, Reynders M, Gerard M, Dauby N, Bourgeois M, Delaere B, Quoilin S, Van Gucht S, Thomas I, Barbezange C. Capturing respiratory syncytial virus season in Belgium using the influenza severe acute respiratory infection surveillance network, season 2018/19. Euro Surveill. 2020 Oct;25(39):1900627. doi: 10.2807/1560-7917.ES.2020.25.39.1900627.

  PMID: 33006303 RESULT

• Fischer N, Moreels S, Dauby N, Reynders M, Petit E, Gerard M, Lacor P, Daelemans S, Lissoir B, Holemans X, Magerman K, Jouck D, Bourgeois M, Delaere B, Quoilin S, Van Gucht S, Thomas I, Bossuyt N, Barbezange C. Influenza versus other respiratory viruses - assessing severity among hospitalised children, Belgium, 2011 to 2020. Euro Surveill. 2023 Jul;28(29):2300056. doi: 10.2807/1560-7917.ES.2023.28.29.2300056.

  PMID: 37470740 RESULT

Biospecimen

Retention: SAMPLES WITH DNA

respiratory specimens (mainly nasopharyngeal swabs, but a few nasal aspirates and broncho-alveolar lavages)

MeSH Terms

Interventions

Respiratory Rate

Intervention Hierarchy (Ancestors)

Vital Signs; Physical Examination; Diagnostic Techniques and Procedures; Diagnosis; Respiration; Respiratory Physiological Phenomena; Circulatory and Respiratory Physiological Phenomena

Study Design

• Study Type: observational
• Observational Model: CASE ONLY
• Time Perspective: RETROSPECTIVE
• Sponsor Type: OTHER GOV
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: scientist

Study Record Dates

• First Submitted: November 9, 2022
• First Posted: November 17, 2022
• Study Start: January 20, 2012
• Primary Completion: April 2, 2020
• Study Completion: April 2, 2020
• Last Updated: September 8, 2023

Record last verified: 2023-09