NCT02027233|Completed
Clinical Trial to Assess the Influenza Vaccination of the Hospitalized Adults
FLUVAC EV-03
Efficiency in Population of Influenza Vaccination for Flu Prevention of the Hospitalized Adults
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FLUVAC EV-03
Efficiency in Population of Influenza Vaccination for Flu Prevention of the Hospitalized Adults
Sponsor study identifier
Secondary identifiers
REGISTRY · IDRCB
interventional
6,173
1 country
1
Study Start
January 2014
Actual (reported)Primary Completion
December 31, 2022
Actual (reported)Study Completion
December 31, 2022
Actual (reported)This study assesses the seasonal of influenza vaccine effectiveness in adults hospitalised with laboratory-confirmed influenza through a network of hospitals in France. Also, To better understand the burden of other respiratory viruses such as respiratory syncytial virus (RSV) and SARS-CoV-2 in hospitalized adults, we need to describe and quantify the population hospitalized due to theses other respiratory viruses.
Registry-reported information. Elapsed time and enrollment totals alone do not measure study progress or recruitment pace.
December 31, 2022
Actual (reported)Click on a node to explore related trials.
Some registry-reported names shown below are not yet linked in this graph.
Dates and qualifiers reported by the registry. Estimated dates do not confirm that a milestone has occurred.
December 12, 2013
Actual (reported)January 2014
Actual (reported)January 6, 2014
Actual (reported)December 31, 2022
Actual (reported)December 31, 2022
Actual (reported)Measure of vaccine efficacy in population by comparing the number of influenza cases virologically documented in hospitalized patients vaccinated and unvaccinated.
The effectiveness of the vaccine in population will be calculated according to the formula VE = 1 - OR. an interval exact confidence of 95% will be calculated on the point estimate.
9 years
Measure of vaccine efficacy in population by age group
9 years
Measure of vaccine efficacy in population by influenza type/subtype
9 years
Description of the population hospitalized for syndrome acute respiratory infection (SARI)
9 years
Rapid completion of nasopharyngeal within 24 hours after hospitalization without exceeding 7 days after the onset
The nasopharyngeal sample will be used to find the types and subtypes of influenza virus and other respiratory viruses (VRS, SARS-CoV-2 and others).
Registry-reported names are shown in full. Names without a link have not yet been matched to a Syfrah profile.
Institut National de la Santé Et de la Recherche Médicale
Paris, 75654, France
Tubiana S, Launay O, Galtier F, Tattevin P, Postil D, Vanhems P, Lenzi N, Verger P, Duval X. Attitudes, knowledge, and willingness to be vaccinated against seasonal influenza among patients hospitalized with influenza-like-illness: impact of diagnostic testing. Hum Vaccin Immunother. 2020 Apr 2;16(4):851-857. doi: 10.1080/21645515.2019.1674598. Epub 2020 Mar 2.
Luque-Paz D, Tattevin P, Loubet P, Benezit F, Thibault V, Laine F, Vanhems P, Amour S, Lina B, Duval X, L'Honneur AS, Fidouh N, Vallejo C, Alain S, Galtier F, Foulongne V, Lagathu G, Lenzi N, Lesieur Z, Launay O, Jouneau S; FLUVAC Study Group. Chronic use of inhaled corticosteroids in patients admitted for respiratory virus infections: a 6-year prospective multicenter study. Sci Rep. 2022 Mar 10;12(1):4199. doi: 10.1038/s41598-022-08089-0.
Odile Launay, PU-PH
Assistance Publique - Hôpitaux de Paris
6,173 participants (actual enrollment reported by the registry).
First Submitted
December 12, 2013
First Posted
January 6, 2014
Study Start
January 2014
Actual (reported)mNGS -Guided Antimicrobial Treatment in Early Severe Community-Acquired Pneumonia Among Immunocompromised Patients
Contact the study team to confirm eligibility.
Loubet P, Samih-Lenzi N, Galtier F, Vanhems P, Loulergue P, Duval X, Jouneau S, Postil D, Rogez S, Valette M, Merle C, Regis C, Costa Y, Lesieur Z, Tattevin P, Lina B, Carrat F, Launay O; FLUVAC Study Group. Factors associated with poor outcomes among adults hospitalized for influenza in France: A three-year prospective multicenter study. J Clin Virol. 2016 Jun;79:68-73. doi: 10.1016/j.jcv.2016.04.005. Epub 2016 Apr 12.
Loubet P, Mathieu P, Lenzi N, Galtier F, Laine F, Lesieur Z, Vanhems P, Duval X, Postil D, Amour S, Rogez S, Lagathu G, L'Honneur AS, Foulongne V, Houhou N, Lina B, Carrat F, Launay O; Fluvac study group. Characteristics of human metapneumovirus infection in adults hospitalized for community-acquired influenza-like illness in France, 2012-2018: a retrospective observational study. Clin Microbiol Infect. 2021 Jan;27(1):127.e1-127.e6. doi: 10.1016/j.cmi.2020.04.005. Epub 2020 Apr 10.
Loubet P, Lenzi N, Valette M, Foulongne V, Krivine A, Houhou N, Lagathu G, Rogez S, Alain S, Duval X, Galtier F, Postil D, Tattevin P, Vanhems P, Carrat F, Lina B, Launay O; FLUVAC Study Group. Clinical characteristics and outcome of respiratory syncytial virus infection among adults hospitalized with influenza-like illness in France. Clin Microbiol Infect. 2017 Apr;23(4):253-259. doi: 10.1016/j.cmi.2016.11.014. Epub 2016 Nov 27.
Descamps A, Lenzi N, Galtier F, Laine F, Lesieur Z, Vanhems P, Amour S, L'Honneur AS, Fidouh N, Foulongne V, Lagathu G, Duval X, Merle C, Lina B, Carrat F, Launay O, Loubet P; FLUVAC study group. In-hospital and midterm post-discharge complications of adults hospitalised with respiratory syncytial virus infection in France, 2017-2019: an observational study. Eur Respir J. 2022 Mar 3;59(3):2100651. doi: 10.1183/13993003.00651-2021. Print 2022 Mar.
Benezit F, Loubet P, Galtier F, Pronier C, Lenzi N, Lesieur Z, Jouneau S, Lagathu G, L'Honneur AS, Foulongne V, Vallejo C, Alain S, Duval X, Houhou N, Costa Y, Vanhems P, Amour S, Carrat F, Lina B, Launay O, Tattevin P; FLUVAC Study Group. Non-influenza respiratory viruses in adult patients admitted with influenza-like illness: a 3-year prospective multicenter study. Infection. 2020 Aug;48(4):489-495. doi: 10.1007/s15010-019-01388-1. Epub 2020 Feb 13.
Primary Completion
December 31, 2022
Actual (reported)Study Completion
December 31, 2022
Actual (reported)Last Updated
April 24, 2026
Record last verified: 2023-10
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