Reducing Respiratory Virus Transmission in Bangladeshi Classrooms
1 other identifier
interventional
20,000
0 countries
N/A
Brief Summary
This study will test if affordable air cleaning devices (box fans with a filter attached and/or ultraviolet light lamps) installed in classrooms can reduce the number of viral respiratory illnesses schoolchildren experience.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P75+ for not_applicable
Started Oct 2025
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
First Submitted
Initial submission to the registry
January 30, 2024
CompletedFirst Posted
Study publicly available on registry
February 7, 2024
CompletedStudy Start
First participant enrolled
October 1, 2025
CompletedPrimary Completion
Last participant's last visit for primary outcome
September 1, 2026
ExpectedStudy Completion
Last participant's last visit for all outcomes
January 1, 2027
April 2, 2025
March 1, 2025
11 months
January 30, 2024
March 28, 2025
Conditions
Keywords
Outcome Measures
Primary Outcomes (1)
Total number of symptomatic respiratory illness episodes due to either Influenza or SARS- CoV-2
Study personnel will visit each school twice weekly. They will identify any students within the study classrooms who were absent or who have symptoms consistent with the World Health Organization (WHO) definition of influenza like illness. For children who were absent or who have symptoms, study personnel will visit the child's home, and if the student's parent provides informed consent, collect more detailed information on signs and symptoms, and a throat swab from the child. The throat swab will be placed on viral transport media, placed on ice and transported to the One Health Laboratory at the International Centre for Diarrhoeal Disease Research, Bangladesh (icddr,b). One aliquot from the specimen will be analyzed for Influenza A, Influenza B, and SARS-CoV-2. In the laboratory, nucleic acid in the throat swab specimen will be extracted and one-step real-time (RT)-PCR conducted to assess the presence of RNA from Influenza A, Influenza B or SARS-CoV-2.
Over 40 weeks of observation
Secondary Outcomes (4)
Total number of symptomatic influenza-like illness episodes
Over 40 weeks of observation
Total number of symptomatic influenza episodes
Over 40 weeks of observation
Total number of symptomatic SARS-CoV2 episodes
Over 40 weeks of observation
Total number of student absentee episodes
Over 40 weeks of observation
Study Arms (4)
Box Fan
EXPERIMENTALClassrooms receive box fans equipped with a filter.
UV Germicidal Irradiation Lamp Unit
EXPERIMENTALClassrooms receive UV germicidal irradiation lamp unit(s).
Combined: Box Fan and UV Germicidal Irradiation Lamp Units
EXPERIMENTALClassrooms receive box fans equipped with a filter and UV germicidal irradiation lamp unit(s).
Non-Interventional Control
NO INTERVENTIONClassrooms receive no intervention to their standard classroom setup.
Interventions
Classrooms assigned to this arm will be equipped with 2 - 8 box fans each with a single minimum efficiency reporting value-14 (MERV-14) filter sufficient to increase effective air changes per hour to 12 based on the clean air delivery rate measured in cubic feet per minute of the box fan + filter \* 60 divided by the room volume.
Classrooms assigned to this arm will be equipped with one or two 222nm wavelength light ultraviolet germicidal irradiation lamp units (number of units per classroom based on room volume).
Classrooms assigned to this arm will be equipped with both box fans and UV germicidal irradiation lamp units.
Eligibility Criteria
You may qualify if:
- Schoolchildren of Bangladesh Government-run primary schools in Dhaka, Bangladesh ages 9 - 12 years, of all gender identifiers (male, female, transgender, prefer not to designate), without specific ethnic selection amongst standard school children of Bangladesh government schools in Dhaka, Bangladesh.
You may not qualify if:
- School children of non-Bangladesh Government-run primary schools and/or schoolchildren who do not attend a Bangladesh Government-run primary school in Dhaka, Bangladesh.
- School children who are not able to or have a contraindication with the ability to comply with study procedures.
Contact the study team to confirm eligibility.
Sponsors & Collaborators
MeSH Terms
Conditions
Condition Hierarchy (Ancestors)
Study Officials
- PRINCIPAL INVESTIGATOR
Stephen P Luby, MD
Stanford University
Central Study Contacts
Study Design
- Study Type
- interventional
- Phase
- not applicable
- Allocation
- RANDOMIZED
- Masking
- SINGLE
- Who Masked
- OUTCOMES ASSESSOR
- Purpose
- PREVENTION
- Intervention Model
- PARALLEL
- Sponsor Type
- OTHER
- Responsible Party
- PRINCIPAL INVESTIGATOR
- PI Title
- Professor of Medicine
Study Record Dates
First Submitted
January 30, 2024
First Posted
February 7, 2024
Study Start
October 1, 2025
Primary Completion (Estimated)
September 1, 2026
Study Completion (Estimated)
January 1, 2027
Last Updated
April 2, 2025
Record last verified: 2025-03
Data Sharing
- IPD Sharing
- Will not share