A New Marker for Early Diagnosis of Pneumoperitoneum-Related Acute Kidney Injury: Insulin-Like Growth Factor-1 (IGF-1)

NCT05612802 | Completed

• 1 other identifier: KA22/178
• Study Type: interventional
• Target: 25
• Locations: 1 country
• Sites: 1

Brief Summary

In our study, to show the effect of pneumoperitoneum on acute kidney injury in patients scheduled for laparoscopic surgery, NGAL and IGF-1 values will be measured before, after and 24 hours after pneumoperitoneum, and these values will be compared. In our study, we aimed to investigate the effect of pneumoperitoneum applied on acute kidney injury in patients who underwent laparoscopic surgery. Creatinine and NGAL have been used successfully in the follow-up of acute kidney injury. Our study investigates whether IGF-1 will be an effective indicator in acute kidney injury by comparing IGF-1 and NGAL values before pneumoperitoneum, after pneumoperitoneum and at the postoperative 24th hour.

Conditions

Acute Kidney Injury (Nontraumatic); Pneumoperitoneum

Outcome Measures

Primary Outcomes (1)

• Diagnosis of acute kidney injury in the early postoperative period with IGF-1 (insulin like growth factor-1)

  The researchers investigate whether IGF-1 will be an effective indicator in acute kidney injury by comparing IGF-1 and NGAL (Neutrophil gelatinase-associated lipocalin) values before pneumoperitoneum, after pneumoperitoneum and at the postoperative 24th hour.

  before pneumoperitoneum, after pneumoperitoneum, and at the postoperative 24th hour.

Study Arms (1)

IGF

OTHER

Creatinine and NGAL have been used successfully in the follow-up of acute kidney injury. In our study, in order to show the effect of pneumoperitoneum on acute kidney injury in patients scheduled for laparoscopic surgery, NGAL and IGF-1 values will be measured before, after and 24 hours after pneumoperitoneum, and these values will be compared.

Diagnostic Test: IGF-1

Interventions

IGF-1 DIAGNOSTIC_TEST

We need to diagnose acute kidney injury in the early postoperative period. The markers examined so far do not provide enough information to diagnose acute kidney injury early. For this reason, many different biomarkers are used in the early diagnosis of acute kidney injury in many parts of the world. Thanks to our research, we can recognise the development of acute kidney injury at an early stage and determine whether a previously unused biomarker (IGF-1) is effective in the early diagnosis of acute kidney injury.

IGF

Eligibility Criteria

• Age: 18 Years - 70 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Patients aged 18-70 years of both sexes
• ASA I-III Patients

You may not qualify if:

• Obesity,
• Chronic Kidney Disease,
• Chronic Renal Failure,
• Acute Renal Failure,
• Peripheral and ischemic vascular disease,
• Chronic Heart Failure,
• History of anaphylaxis,
• A-V block,
• Creatinine level \>1.4,
• Neuromuscular disease,
• Malignant hypertension,
• Pyelonephritis,
• Urinary tract infectio,
• Severe inflammation/possible sepsis,
• Active malignancy,

Sponsors & Collaborators

• Baskent University: lead

Study Sites (1)

Çağla Yazar, MD

Ankara, 06560, Turkey (Türkiye)

Location

Related Publications (4)

• Gumbert SD, Kork F, Jackson ML, Vanga N, Ghebremichael SJ, Wang CY, Eltzschig HK. Perioperative Acute Kidney Injury. Anesthesiology. 2020 Jan;132(1):180-204. doi: 10.1097/ALN.0000000000002968.

  PMID: 31687986 BACKGROUND

• Marton Filho MA, Alves RL, Nascimento PD Junior, Tarquinio GDS, Mega PF, Pinheiro Modolo NS. Effects of pneumoperitoneum on kidney injury biomarkers: A randomized clinical trial. PLoS One. 2021 Feb 19;16(2):e0247088. doi: 10.1371/journal.pone.0247088. eCollection 2021.

  PMID: 33606739 BACKGROUND

• Sun B, Fu A, Wang R, Zhang Y. Influence of carbon dioxide pneumoperitoneum on the growth hormone-insulin-like growth factor I axis in mid- and late-pregnancy rats. J Obstet Gynaecol Res. 2015 Sep;41(9):1394-8. doi: 10.1111/jog.12734. Epub 2015 Jun 22.

  PMID: 26098754 BACKGROUND

• Srisawat N, Kongwibulwut M, Laoveeravat P, Lumplertgul N, Chatkaew P, Saeyub P, Latthaprecha K, Peerapornratana S, Tiranathanagul K, Eiam-Ong S, Tungsanga K. The role of intraoperative parameters on predicting laparoscopic abdominal surgery associated acute kidney injury. BMC Nephrol. 2018 Oct 22;19(1):289. doi: 10.1186/s12882-018-1081-4.

  PMID: 30348111 BACKGROUND

MeSH Terms

Conditions

Acute Kidney Injury; Pneumoperitoneum

Condition Hierarchy (Ancestors)

Renal Insufficiency; Kidney Diseases; Urologic Diseases; Female Urogenital Diseases; Female Urogenital Diseases and Pregnancy Complications; Urogenital Diseases; Male Urogenital Diseases; Peritoneal Diseases; Digestive System Diseases

Study Officials

• NEDİM ÇEKMEN, PHD

  Baskent University

  STUDY DIRECTOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NA
• Masking: NONE
• Purpose: DIAGNOSTIC
• Intervention Model: SINGLE GROUP
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Principal investigator

Study Record Dates

• First Submitted: September 6, 2022
• First Posted: November 10, 2022
• Study Start: February 8, 2023
• Primary Completion: March 30, 2023
• Study Completion: May 30, 2023
• Last Updated: January 5, 2024

Record last verified: 2024-01

Data Sharing

• IPD Sharing: Will not share

Locations

TU (1)