Effects of Eccentric Potentiation Activation on Muscle Function

NCT05606276 | Withdrawn

• 1 other identifier: 12042c
• Study Type: interventional
• Target: N/A
• Locations: 1 country
• Sites: 1

Brief Summary

The purpose of this study is to examine the potentiation effects of 2 sets of multi-joint eccentric overload maximal contractions on muscle function.

Conditions

Post Activation Potentiation

Outcome Measures

Primary Outcomes (8)

• Vertical Jump

  3 countermovement vertical jumps, with 30 seconds of rest between attempts

  Baseline (pretest)

• Vertical Jump

  3 countermovement vertical jumps, with 30 seconds of rest between attempts

  Immediately post intervention

• Vertical Jump

  3 countermovement vertical jumps, with 30 seconds of rest between attempts

  12 minutes post intervention

• Vertical Jump

  3 countermovement vertical jumps, with 30 seconds of rest between attempts

  20 minutes post intervention

• Isokinetic eccentric maximal strength

  Maximal eccentric strength on the Eccentron machine. 2 repetitions per time point

  Baseline (pretest)

• Isokinetic eccentric maximal strength

  Maximal eccentric strength on the Eccentron machine. 2 repetitions per time point

  Immediately post intervention

• Isokinetic eccentric maximal strength

  Maximal eccentric strength on the Eccentron machine. 2 repetitions per time point

  12 minutes post intervention

• Isokinetic eccentric maximal strength

  Maximal eccentric strength on the Eccentron machine. 2 repetitions per time point

  20 minutes post intervention

Study Arms (2)

Cycling exercise

ACTIVE COMPARATOR

Cycling on a cycle ergometer instead of doing the experimental eccentric exercise.

Other: Cycle ergometer

Eccentric exercise

EXPERIMENTAL

Perform 2 sets of maximal eccentric contractions as the single session exercise intervention.

Other: Eccentric Exercise

Interventions

Eccentric Exercise OTHER

Individuals will do a randomized crossover intervention involving maximal eccentric contractions (2 sets of 6 per leg; experimental condition)

Eccentric exercise

Cycle ergometer OTHER

Individuals will do a randomized crossover intervention involving cycling (active control) exercise

Cycling exercise

Eligibility Criteria

• Age: 18 Years - 30 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)

You may not qualify if:

• lower body surgery or injury in the last 12 months
• have any neuromuscular disease
• height \>76 inches tall
• height \<54 inches tall
• eccentric strength greater than 725 pounds
• pregnant or plan to be pregnant in the duration of the protocol
• don't do resistance exercise at least once per week
• perform intense cardio or strength training \>4 days per week
• Present with any other significant comorbid conditions that would impair the ability to participate in the exercise-based testing
• years old
• strength train lower body 1-3 times per week

Sponsors & Collaborators

• Brennan Thompson: lead

Study Sites (1)

Utah State University

Logan, Utah, 84322, United States

Location

Study Officials

• Brennan J Thompson, PhD

  Utah State University

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: SINGLE
• Who Masked: INVESTIGATOR
• Purpose: OTHER
• Intervention Model: CROSSOVER
• Sponsor Type: OTHER
• Responsible Party: SPONSOR INVESTIGATOR
• PI Title: Associate Professor

Model Details: Following a familiarization session, subjects will be assigned to an order for performing both an eccentric and a cycle (sham) session (i.e., crossover design, the order being randomized). These will be performed 3-7 days apart.

Study Record Dates

• First Submitted: October 24, 2022
• First Posted: November 4, 2022
• Study Start: November 1, 2022
• Primary Completion: March 1, 2024
• Study Completion: March 1, 2024
• Last Updated: April 23, 2024

Record last verified: 2024-04

Locations

US (1)