NCT05606003

Brief Summary

In collaboration with community partners, this study will identify disparities and dynamics of COVID-19 testing and infections in three Texas regions; and implement a multilevel intervention that increases access to testing and referrals to follow-up care among vulnerable populations. Using a three-arm group-randomized controlled trial, this study will assess the impact of multi-level interventions influencing motivation and access to testing. The outcomes of this study are measured at the population level and no individual data will be gathered. Analyses of de-identified PHI data from local and regional health departments on COVID testing and infection rates will be used to assess intervention outcomes.

Trial Health

43
At Risk

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Trial has exceeded expected completion date
Enrollment
1,280

participants targeted

Target at P75+ for not_applicable covid19

Timeline
Completed

Started Jun 2021

Typical duration for not_applicable covid19

Geographic Reach
1 country

3 active sites

Status
unknown

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

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Study Timeline

Key milestones and dates

Study Start

First participant enrolled

June 7, 2021

Completed
1.1 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

June 30, 2022

Completed
3 months until next milestone

First Submitted

Initial submission to the registry

September 19, 2022

Completed
2 months until next milestone

First Posted

Study publicly available on registry

November 4, 2022

Completed
2 months until next milestone

Study Completion

Last participant's last visit for all outcomes

December 30, 2022

Completed
Last Updated

November 4, 2022

Status Verified

November 1, 2022

Enrollment Period

1.1 years

First QC Date

September 19, 2022

Last Update Submit

November 3, 2022

Conditions

Keywords

COVID-19 testingdecision makingtesting behaviorsvulnerable populations

Outcome Measures

Primary Outcomes (1)

  • Testing Uptake

    Examine the short and long-term change in testing proportion from baseline in the CBGs adjusted for testing capacity (testing proportion in the county during the same time period)

    Baseline through study completion (26 months)

Secondary Outcomes (1)

  • Disparities in Testing

    Baseline through study completion (26 months)

Study Arms (3)

Multi-level Multi-Component Intervention (MLI)

EXPERIMENTAL

Individuals receive COVID-19 CHW-delivered education and navigation, 2-1-1 helpline referrals, and social marketing messaging.

Behavioral: Multi-Level Multi-Component Intervention (MLI)

Community Just-in-Time-Adaptive Intervention (JITAI)

EXPERIMENTAL

Individuals receive MLI intervention components that are informed by real-time data and community stakeholder feedback.

Behavioral: Community Just-In-Time Adaptive Intervention (Community JITAI)

Comparison Condition

NO INTERVENTION

Individuals receive standard exposure to ongoing city and county COVID-19 communication and testing.

Interventions

The strategic components of our multi-level, multi-component intervention (MLI) include: 1. Building testing access for vulnerable populations, 2) Community Health Worker (CHW)-delivered navigation to SARSCoV- 2 testing and access and reinforce risk mitigation recommendations, 3) 2-1-1 helpline-referrals and navigation to FDA approved SARSCoV- 2 testing (and self sampling once approved) and risk mitigation education, and 4) social marketing and small media campaign to provide geo-targeted messages promoting testing and COVID risk mitigation behaviors. We selected these components because of their evidence base, their current use by partners in response to COVID 19, and confidence that they can be adapted through a community engaged process as described.

Multi-level Multi-Component Intervention (MLI)

This intervention includes the same MLI components described above, with an added JITAI approach. Community and stakeholder partners will use real-time data related to testing and other relevant information generated by the Epidemiologic Surveillance and Analysis team (ESA) in Aim 1, as well as other information based on their community and stakeholder experience and tacit knowledge about factors influencing testing determinants, to adapt intervention activities as needed to optimize access to testing.

Community Just-in-Time-Adaptive Intervention (JITAI)

Eligibility Criteria

Age18 Years+
Sexall
Healthy VolunteersNo
Age GroupsAdult (18-64), Older Adult (65+)

You may qualify if:

  • residing in identified COVID-19 hotspots and testing deserts within study regions
  • aged 18 years or older

You may not qualify if:

  • aged under 18 years

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (3)

The University of Texas Health Science Center, Brownsville

Brownsville, Texas, 78520, United States

Location

The University of Texas Health Science Center at Houston

Houston, Texas, 77030, United States

Location

The University of Texas Health Science Center at Tyler

Tyler, Texas, 75708, United States

Location

MeSH Terms

Conditions

COVID-19

Condition Hierarchy (Ancestors)

Pneumonia, ViralPneumoniaRespiratory Tract InfectionsInfectionsVirus DiseasesCoronavirus InfectionsCoronaviridae InfectionsNidovirales InfectionsRNA Virus InfectionsLung DiseasesRespiratory Tract Diseases

Study Officials

  • Maria Fernandez, PhD

    The University of Texas Health Science Center, Houston

    PRINCIPAL INVESTIGATOR
  • Belinda E Reininger, DrPh

    The University of Texas Health Science Center, Brownsville

    PRINCIPAL INVESTIGATOR
  • David D McPherson, MD

    The University of Texas Health Science Center, Houston

    PRINCIPAL INVESTIGATOR
  • Paul McGaha, DO

    The University of Texas Health Science Center, Tyler

    PRINCIPAL INVESTIGATOR
  • Marcia C de Oliveira Otto, PhD

    The University of Texas Health Science Center, Houston

    PRINCIPAL INVESTIGATOR
  • Kayo Fujimoto, PhD

    The University of Texas Health Science Center, Houston

    PRINCIPAL INVESTIGATOR

Study Design

Study Type
interventional
Phase
not applicable
Allocation
RANDOMIZED
Masking
NONE
Purpose
OTHER
Intervention Model
PARALLEL
Sponsor Type
OTHER
Responsible Party
PRINCIPAL INVESTIGATOR
PI Title
Lorne Bain Distinguished Professorship in Public Health and Director, Center for Health Promotion and Prevention Research

Study Record Dates

First Submitted

September 19, 2022

First Posted

November 4, 2022

Study Start

June 7, 2021

Primary Completion

June 30, 2022

Study Completion

December 30, 2022

Last Updated

November 4, 2022

Record last verified: 2022-11

Data Sharing

IPD Sharing
Will not share

Locations