NCT04832919

Brief Summary

Historically, health disparities in the US are concentrated among underserved communities and socially vulnerable populations. The disproportionate COVID-19 related morbidity and mortality in communities of color and socioeconomic disadvantage acutely highlight this persistent public health problem, drawing attention to the urgent need for more equitable reach of testing, prevention, and control measures. The proposed research addresses this need using a 2-arm randomized controlled trial (RCT) that will evaluate the effectiveness of the Nurse-Community Health Worker (CHW)-Family Partnership intervention in promoting COVID-19 testing uptake, adoption of COVID control measures, and mutual aid capacity at the household level in an underserved and vulnerable population disproportionately affected by COVID-19. Enrolled households will be randomly assigned to either the intervention group where families will receive the Nurse-CHW-Family Partnership intervention including the offer of in-home testing and referral to seasonal influenza vaccination services, or the treatment-as-usual control group, which will be used to measure actual testing rates among public housing residents in relation to participant and household characteristics. The study hypothesis is that the Nurse-CHW-Family Partnership intervention will improve household-level COVID-19 testing uptake, adoption of COVID control measures, and mutual aid capacity relative to the treatment-as-usual control.

Trial Health

43
At Risk

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Trial has exceeded expected completion date
Enrollment
392

participants targeted

Target at P75+ for not_applicable covid19

Timeline
Completed

Started Jul 2021

Longer than P75 for not_applicable covid19

Geographic Reach
1 country

1 active site

Status
unknown

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

First Submitted

Initial submission to the registry

April 2, 2021

Completed
4 days until next milestone

First Posted

Study publicly available on registry

April 6, 2021

Completed
4 months until next milestone

Study Start

First participant enrolled

July 23, 2021

Completed
1.7 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

April 1, 2023

Completed
Same day until next milestone

Study Completion

Last participant's last visit for all outcomes

April 1, 2023

Completed
Last Updated

December 15, 2022

Status Verified

July 1, 2022

Enrollment Period

1.7 years

First QC Date

April 2, 2021

Last Update Submit

December 13, 2022

Conditions

Keywords

SARS-CoV-2COVID-19COVID-19 testingBehavioral COVID-19 Mitigation Measures

Outcome Measures

Primary Outcomes (2)

  • Household COVID-19 Testing Uptake

    All medical services delivered by nurses during home-visits (such as COVID-19 test administration) will be carefully documented by the investigative team. At the time of the assessment, the investigators will obtain self-reported information regarding COVID-19 testing uptake by study participants in the treatment and control groups. Respondents will be asked whether they have received COVID-19 testing in the past three months \[Yes/No\].

    Delayed Follow-Up (9 Months)

  • COVID-19 Symptoms, Diagnoses, and Testing Scale

    An adapted version of the (PhenX Toolkit) COVID-19 Symptoms, Diagnoses, and Testing Scale will be used to measure COVID-19 symptoms, diagnoses, and testing. Participants will be asked questions regarding whether they are currently sick with an illness that might be related to COVID-19, any symptoms the participant experienced in the past three months \[Check All That Apply\], and the result of the participant's last COVID-19 test \[Positive/Negative\].

    Delayed Follow-Up (9 Months)

Secondary Outcomes (10)

  • COVID-19 Avoidant Behaviors Scale

    Delayed Follow-Up (9 Months)

  • Vaccine Uptake

    Delayed follow up (9 months)

  • COVID-19 Improved Household & Family Mutual Aid

    Delayed follow up (9 months)

  • COVID-19 Household Environment Scale

    Delayed follow up (9 months)

  • Household COVID-19 Testing Uptake

    Immediate follow up (6 months)

  • +5 more secondary outcomes

Study Arms (2)

Nurse-Community Health Worker-Family Partnership

EXPERIMENTAL

The experimental arm will receive the Nurse-Community Health Worker-Family Partnership intervention

Behavioral: Nurse-Community-Family Partnership Intervention

Standard of Care

NO INTERVENTION

The control arm will receive standard access to NYC Department of Health COVID-19 testing sites and standard COVID-19 public health messaging

Interventions

Nurses conduct home visits on a monthly basis for the first five months post-baseline. During visits, nurses emphasize the importance of infection control measures and, jointly with household members, develop and follow-up on the implementation of an infection control plan tailored to the unique circumstances of the household. Nurses deliver training on infection control skills necessary for optimal implementation of the plan. Nurses offer at-home SARS-CoV-2 testing to all members of the household. Nurses conduct triage, medical case management, monitoring, and follow-up of individuals identified to have COVID-19 or any other acute health emergencies. CHWs conduct visits on a bi-weekly basis for the first five months post-baseline. CHWs deliver healthcare information and medical mistrust counseling in a culturally relevant and linguistically appropriate fashion; and provide social support, navigate household members to social welfare/vocational/economic/psychosocial services.

Nurse-Community Health Worker-Family Partnership

Eligibility Criteria

Age10 Years+
Sexall
Healthy VolunteersYes
Age GroupsChild (0-17), Adult (18-64), Older Adult (65+)

You may qualify if:

  • Residence in one of the public housing complexes in Mott Haven, South Bronx
  • English or Spanish-speaking
  • Age 10 years or older
  • Willing and able to provide informed consent or assent

You may not qualify if:

  • Non-resident of one of the public housing complexes in Mott Haven, South Bronx
  • Neither English nor Spanish speaker
  • Younger than 10 years old, unless household index case tests antigen positive. In this instance, all members of family will be included.
  • Unwilling or unable to provide informed consent or assent

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

New York University

New York, New York, 10003, United States

Location

Related Publications (1)

  • Guilamo-Ramos V, Benzekri A, Williams D, Thimm-Kaiser M, Wizentier MM, Goodman M, Amezquita-Castro B, Hagan H. A nurse-led clinical practice model to increase healthcare reach among underserved families during public health emergencies: A randomized controlled trial. Nurs Outlook. 2025 Nov-Dec;73(6):102591. doi: 10.1016/j.outlook.2025.102591. Epub 2025 Nov 6.

MeSH Terms

Conditions

COVID-19

Condition Hierarchy (Ancestors)

Pneumonia, ViralPneumoniaRespiratory Tract InfectionsInfectionsVirus DiseasesCoronavirus InfectionsCoronaviridae InfectionsNidovirales InfectionsRNA Virus InfectionsLung DiseasesRespiratory Tract Diseases

Study Officials

  • Vincent M Guilamo-Ramos, PhD

    New York University

    PRINCIPAL INVESTIGATOR
  • Holly Hagan, PhD

    New York University

    PRINCIPAL INVESTIGATOR

Study Design

Study Type
interventional
Phase
not applicable
Allocation
RANDOMIZED
Masking
SINGLE
Who Masked
OUTCOMES ASSESSOR
Purpose
PREVENTION
Intervention Model
PARALLEL
Sponsor Type
OTHER
Responsible Party
SPONSOR

Study Record Dates

First Submitted

April 2, 2021

First Posted

April 6, 2021

Study Start

July 23, 2021

Primary Completion

April 1, 2023

Study Completion

April 1, 2023

Last Updated

December 15, 2022

Record last verified: 2022-07

Data Sharing

IPD Sharing
Will share

The project team will share all individual participant data that underlie the results reported in any future published manuscript, after deidentification (text, tables, figures, and appendices). We will make available the study protocol and statistical analysis plan. The project team will make the data available beginning 3 months and ending 5 years following article publication to investigators whose proposed use of the data has been approved by an independent review committee identified for this purpose. Investigators will be approved to conduct analyses to achieve the aims in the proposal that they submit for approval by an independent review committee. Proposals should be directed to Dr. Holly Hagan (hh50@nyu.edu). To gain access, data requesters will need to sign a data access agreement.

Shared Documents
STUDY PROTOCOL, SAP
Time Frame
The project team will make the data available beginning 3 months and ending 5 years following article publication.
Access Criteria
The project team will make the data available for investigators whose proposed use of the data has been approved by an independent review committee identified for this purpose.

Locations