YoUng Adolescents' behaViour, musculoskeletAl heAlth, Growth & Nutrition

NCT05603793 | Active Not Recruiting DMC

• 1 other identifier: YUVAAN
• Study Type: observational
• Target: 1,304
• Locations: 1 country
• Sites: 1

Brief Summary

More children will survive to adulthood today than at any other point in human history, as evidenced by the proportion of live births and absolute numbers. The present generation of young people who have lived to the age of five will reach adulthood around 2030 and will be the generation of the Sustainable Development Goals (SDGs). These children's health and nutrition as they grow from 5 to 19 years will have permanent ramifications on the development of the coming generation. The Comprehensive National Nutrition Survey was conducted between 2016 and 2018, indicating unacceptably high levels of malnutrition among Indian children and adolescents. It was discovered that one out of every five children aged 5 to 9 was stunted, indicating they were malnourished for their age. Undernourished girls are more likely to become short-statured mothers, giving birth to low-birth-weight and stunted newborns who are more prone to disease and linear growth failure. Evidence suggests that maternal short stature (less than 150 cm) predicts childhood growth failure and increases the risk of having a stunted baby by two years. The common genetic background and environmental influences that affect the mother during her early childhood and adolescence play a substantial role in the relationship between maternal stature and the linear growth of the child. This causes a cycle of undernutrition and poor growth that continues through generations and impacts the offspring's growth. Adolescence is a key period of physical and social development when the physiological, mental, and behavioural underpinnings of long-term health are established. The development of critical bone mass is crucial during this time because it lays the foundation for preserving bone mineral integrity later in life. During adolescence, over 40% of peak bone mass is achieved. Changes in body composition are also seen during early adolescence. These physiological processes are both nutritionally sensitive and predictive of their future health. Adolescent behaviour is also linked to 33 percent of sickness and 60 percent of premature deaths in adulthood. Because adolescence is also a critical period for the development of the ability to make independent decisions, follow them through, and achieve goals- enabling healthy social networks, is critical. This includes Social and Behavioural Change Communications, which can assist early adolescents create lifetime behaviour patterns, such as good nutrition and physical exercise choices. Investing in adolescent health and well-being pays off in three ways: during their adolescence, in their adulthood, and for their future offspring generations. Thus, young adolescence provides a "window of opportunity" for children to improve their nutritional health and outcomes. Therefore, this cohort aims to explore the trajectories of growth (including anthropometric measures, bone mass, and muscle mass and function) among rural young adolescents and its association with intergenerational nutritional status through a longitudinal study. A greater understanding of growth trajectories set in a longitudinal study would aid in the discovery of particular variables that influence the timing of young adolescents' growth and the factors associated with intergenerational nutritional status.

Conditions

Arrest of Bone Development or Growth; Constitutional Delay of Growth and Puberty; Malnutrition, Child; Gestational Diabetes; Muscle Tone Abnormalities; Anemia

Keywords

adolescent; growth; malnutrition; cycle of nutrition; cohort

Outcome Measures

Primary Outcomes (2)

• Wasting

  Wasting measured as \< -2 Weight-for-height z-score

  From date of enrolment, until study completion, assessed every 6 months

• Stunting

  Stunting measured as \< -2 Height-for-age z-score

  From date of enrolment, until study completion, assessed every 6 months

Secondary Outcomes (5)

• Body mass and composition

  From date of enrolment, until study completion, assessed every 6 months

• Dynamic muscle function

  From date of enrolment, until study completion, assessed every 1 year

• Bone mineral density (BMD)

  From date of enrolment, until study completion, assessed every 1 year

• Bone volumetric density

  From date of enrolment, until study completion, assessed every 1 year

• Bone age

  From date of enrolment, until study completion, assessed every 6 months

Other Outcomes (1)

• Household Dietary Diversity Scale (HDDS)

  From date of enrolment, until study completion, assessed every 6 months

Interventions

Knowledge, Attitude & Practices BEHAVIORAL

The objective the of the KAP intervention is to explore key aspects related to child health and nutrition to better understand the community's knowledge, perception and practices. In addition to child health, we are also tracking the transition of health from urban to rural areas in terms of the prevalence of adult non-communicable diseases.

Eligibility Criteria

• Age: 8 Years - 10 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Child (0-17)
• Sampling Method: Probability Sample

Study Population

The population is homogeneous in living conditions, socioeconomic status, and dietary habits. Most people are engaged in agriculture and have a low migration rate, which makes it an optimal setting for conducting cohort studies. Since our study aims to find the association between intergenerational nutritional status and growth in three generations, the study will extend to years. For such long-duration investigations, it was important to select study cohorts that are not likely to migrate, are cooperative and are likely to be so throughout the duration of the study, and most importantly, easily accessible to the investigator so that the expense and efforts are kept within reasonable limits (Banerjee \& Chaudhury, 2010).

You may qualify if:

• Age between 8 and 10 years during the period of enrollment
• Children with both biological parents (mother and father) present during the period of enrollment
• Apparently healthy children

You may not qualify if:

• Any chronic untreated/ progressive condition that would adversely affect growth, bone and/or muscle health of the participant
• Migrant families and temporary residents as defined by Census of India (Office of the Registrar General \& Census Commissioner, India Ministry of Home Affairs, 2022)
• Refusal to give informed consent and/or parental assent

Sponsors & Collaborators

• Hirabai Cowasji Jehangir Medical Research Institute: lead

Study Sites (1)

Hirabai Cowasji Jehangir Medical Research Institute

Pune, Maharashtra, 411001, India

Location

Related Publications (1)

• Miriam D, Mandlik R, Patwardhan V, Ladkat D, Khadilkar V, Kajale N, More C, Gondhalekar K, Bhawra J, Katapally TR, Khadilkar AV. An observational, multigenerational platform for health systems and population health interventions to minimise intergenerational transmission of non-communicable diseases in India: the YUVAAN cohort study protocol. BMJ Public Health. 2025 Feb 6;3(1):e001741. doi: 10.1136/bmjph-2024-001741. eCollection 2025.

  PMID: 40017955 DERIVED

Related Links

• Cardiovascular and metabolic consequences of obesity.
• Maternal and child undernutrition and overweight in low-income \& middle-income countries
• Prevalence and factors associated with anemia in 6-18 years urban and rural Indian children and adolescents: A multicenter study.
• Determinants of muscle power and force as assessed by Jumping Mechanography in rural Indian children.

MeSH Terms

Conditions

Child Nutrition Disorders; Diabetes, Gestational; Anemia; Malnutrition

Condition Hierarchy (Ancestors)

Nutrition Disorders; Nutritional and Metabolic Diseases; Pregnancy Complications; Female Urogenital Diseases and Pregnancy Complications; Urogenital Diseases; Diabetes Mellitus; Glucose Metabolism Disorders; Metabolic Diseases; Endocrine System Diseases; Hematologic Diseases; Hemic and Lymphatic Diseases

Study Officials

• Anuradha V Khadilkar, MD

  HCJMRI

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Deputy director

Study Record Dates

• First Submitted: October 10, 2022
• First Posted: November 3, 2022
• Study Start: September 13, 2022
• Primary Completion (Estimated): September 25, 2047
• Study Completion (Estimated): September 25, 2050
• Last Updated: September 23, 2025

Record last verified: 2025-09

Data Sharing

• IPD Sharing: Will not share

Locations

IN (1)