Assessing the Feasibility of Economic Approaches to Prevent Substance Abuse Among Adolescents

NCT05597865 | Completed Results

• 1 other identifier: 1R21AA030225-01
• Study Type: interventional
• Target: 95
• Locations: 1 country
• Sites: 1

Brief Summary

The proposed study will test the impact of an economic empowerment intervention on reducing alcohol and drug use (ADU) among adolescents and youth living with HIV (AYLHIV) in poverty-impacted communities in Uganda. It focuses on improving understanding of multi-level context- specific risk and protective factors for ADU among AYLHIV.

Conditions

Adolescent Drinking; HIV/AIDS; Drug Use

Outcome Measures

Primary Outcomes (2)

• Percentage of Participants Completing the Study at 6 Months

  Percentage of participants completing the study at 6 months

  Baseline and 6 months

• Number of Participants Enrolling in the Study at Baseline

  Number of participants enrolling in the study at baseline

  Baseline

Secondary Outcomes (16)

• Percentage of Participants That Self-reported Use of Any Drug in the Last 3 Months at the Baseline Assessment

  baseline

• Percentage of Participants That Self-reported Use of Any Drug in Last 3 Months at the 6-month Assessment

  6 month follow-up

• Optimism Scale Total Score at Baseline

  Baseline

• Optimism Scale Total Score at 6 Months

  6 months

• Beck Hopelessness Scale Total Score at Baseline

  Baseline

Study Arms (2)

Control Arm

OTHER

Control arm will received Alcohol and Drug Use Risk Reduction Sessions

Behavioral: Alcohol and Drug Use Risk Reduction Sessions

Intervention

EXPERIMENTAL

Participants in the intervention arm will receive four (4) Financial Literacy (FL) training sessions and receive a Youth Development Savings account (YDA) at a financial institution accredited by the Bank of Uganda for long-term savings. Each YDA account will be opened in the name of the participant. Savings will be matched at a 1:1 rate with money from the program.

Behavioral: Economic Empowerment Intervention; Behavioral: Alcohol and Drug Use Risk Reduction Sessions

Interventions

Economic Empowerment Intervention BEHAVIORAL

Economic Empowerment Intervention comprising Financial Literacy Sessions and Youth Development Accounts

Intervention

Alcohol and Drug Use Risk Reduction Sessions BEHAVIORAL

All participants in the control and treatment arm will receive Alcohol and Drug Use Risk Reduction sessions tailored for Adolescents and Youths Living with HIV.

Control Arm; Intervention

Eligibility Criteria

• Age: 18 Years - 24 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)

You may qualify if:

• male or female AYLHIV aged 15-24 years;
• medically diagnosed with HIV and aware of their HIV status;
• enrolled in care at one of the selected HIV clinics.
• positive self-report or urine test for alcohol or drug use

You may not qualify if:

• any AYLHIV with negative urine alcohol or drug use test and negative self-report for alcohol and drug use
• anyone with a significant cognitive impairment that interferes with their understanding of the informed consent process, or is unable/unwilling to consent.

Sponsors & Collaborators

• Washington University School of Medicine: lead
• National Institute on Alcohol Abuse and Alcoholism (NIAAA): collaborator

Study Sites (1)

International Center for Child Health and Development Field Office

Masaka, Uganda

Location

Related Publications (1)

• Brathwaite R, Mutumba M, Nanteza J, Filiatreau LM, Migadde H, Namatovu P, Nabisere B, Mugisha J, Mwebembezi A, Ssewamala FM. Assessing the Feasibility of Economic Approaches to Prevent Substance Abuse Among Adolescents: Protocol for a Mixed Methods Study. JMIR Res Protoc. 2023 Jun 14;12:e46486. doi: 10.2196/46486.

  PMID: 37314844 DERIVED

MeSH Terms

Conditions

Underage Drinking; Acquired Immunodeficiency Syndrome

Interventions

Ethanol

Condition Hierarchy (Ancestors)

Adolescent Behavior; Behavior; Alcohol Drinking; Drinking Behavior; HIV Infections; Blood-Borne Infections; Communicable Diseases; Infections; Sexually Transmitted Diseases, Viral; Sexually Transmitted Diseases; Lentivirus Infections; Retroviridae Infections; RNA Virus Infections; Virus Diseases; Slow Virus Diseases; Genital Diseases; Urogenital Diseases; Immunologic Deficiency Syndromes; Immune System Diseases

Intervention Hierarchy (Ancestors)

Alcohols; Organic Chemicals

Results Point of Contact

• Title: Rachel Brathwaite
• Organization: Washington University in St. Louis

rachel.brathwaite@yahoo.com

3147282869

Study Officials

• Rachel Brathwaite, PhD

  Washington University School of Medicine

  PRINCIPAL INVESTIGATOR

Publication Agreements

• PI is Sponsor Employee: Yes
• Restrictive Agreement: No

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: SINGLE
• Who Masked: PARTICIPANT
• Purpose: PREVENTION
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: October 20, 2022
• First Posted: October 28, 2022
• Study Start: October 12, 2023
• Primary Completion: June 6, 2024
• Study Completion: June 6, 2024
• Last Updated: December 2, 2025
• Results First Posted: December 2, 2025

Record last verified: 2025-11

Data Sharing

• IPD Sharing: Will share
• Shared Documents: STUDY PROTOCOL
• Time Frame: These data will be available within 24 months after completing the study, and access will be maintained for 10 years.

Locations

UG (1)