NCT05590780|Completed
Analysis of Cell-free DNA (cfDNA) During Periodontitis
Analysis of the Impact of Cell-free DNA (cfDNA) During Periodontitis and Cardiovascular Disease
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Analysis of the Impact of Cell-free DNA (cfDNA) During Periodontitis and Cardiovascular Disease
Sponsor study identifier
observational
122
1 country
1
Study Start
November 1, 2019
Actual (reported)Primary Completion
June 30, 2022
Actual (reported)Study Completion
June 30, 2022
Actual (reported)The purpose of this study was to examine the association between circulating cfDNA concentration and CVD risk in patients with periodontitis, CVD, and periodontitis plus CVD. In addition, the secondary objective was to identify, among other confounders, the impact of periodontitis and cardiovascular disease as potential significant predictors of circulating cfDNA levels in the enrolled population.
Registry-reported information. Elapsed time and enrollment totals alone do not measure study progress or recruitment pace.
June 30, 2022
Actual (reported)Click on a node to explore related trials.
Some registry-reported names shown below are not yet linked in this graph.
Dates and qualifiers reported by the registry. Estimated dates do not confirm that a milestone has occurred.
November 1, 2019
Actual (reported)June 30, 2022
Actual (reported)June 30, 2022
Actual (reported)October 18, 2022
Actual (reported)October 21, 2022
Actual (reported)Clinical attachment level loss
Evaluation of changes (in millimeters) of Clinical attachment level loss
baseline changes
circulating cell-free DNA
Evaluation of changes (in millimeters) of plasma circulating cell-free DNA
baseline changes
Evaluation of plasma cfDNA levels
Evaluation of plasma cfDNA levels
Evaluation of plasma cfDNA levels
Evaluation of plasma cfDNA levels
1-year
Registry-reported names are shown in full. Names without a link have not yet been matched to a Syfrah profile.
healthy controls (n=30) and subjects with CVD (n=31), periodontitis (n=31) and periodontitis+CVD (n=30) were enrolled.
University of Catania
Catania, CT, 95124, Italy
Gaetano Isola
Università degli Studi di Catania
122 participants (actual enrollment reported by the registry).
First Submitted
October 18, 2022
First Posted
October 21, 2022
Study Start
November 1, 2019
Actual (reported)Connecting Periodontal and Coronary Artery Disease Via the Inflammatory State of the Body
Contact the study team to confirm eligibility.
Primary Completion
June 30, 2022
Actual (reported)Study Completion
June 30, 2022
Actual (reported)Last Updated
May 23, 2023
Record last verified: 2023-05
Download the complete ClinicalTrials.gov record imported by Syfrah, including fields not shown in this page. The registry may contain a newer revision.
Source: ClinicalTrials.gov.
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