NCT05275127

Completed

Impact of Periodontal Treatment on Local miRNA Expression

University of Catania Source

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Other study identifiers

Sponsor study identifier

215/21/PO

Study Type

observational

Actual enrollment (reported)

89

Locations

1 country

Sites

1

Timeline

Study Start

March 14, 2022

Actual (reported)

Primary Completion

November 15, 2022

Actual (reported)

Study Completion

November 20, 2022

Actual (reported)

Brief Summary

To assess the impact of Fill Mouth Scaling and Root planing or Quadrant Scaling and Root planing gingival crevicular fluid (GCF) levels of miRNA 7a-5p, miRNA 21-3p, miRNA 21-5p, miRNA 100-5p, miRNA 125-5p, miRNA 200b-3p and miRNA 200b-5p and their correlation with periodontitis extent.

Registry Overview

Registry-reported information. Elapsed time and enrollment totals alone do not measure study progress or recruitment pace.

Recruitment status: completed
Actual enrollment (reported): 89 participants
Study completion date: November 20, 2022
Actual (reported)
Listed locations: 1 countries · 1 sites

Trial Relationships

Click on a node to explore related trials.

Some registry-reported names shown below are not yet linked in this graph.

Study Timeline

Dates and qualifiers reported by the registry. Estimated dates do not confirm that a milestone has occurred.

First Submitted
February 8, 2022
Actual (reported)
First Posted
March 11, 2022
Actual (reported)
Study Start
March 14, 2022
Actual (reported)
Primary Completion
November 15, 2022
Actual (reported)
Study Completion
November 20, 2022
Actual (reported)

Last Updated: October 16, 2026
Status Verified: October 2026
Last Update Submitted: October 13, 2026

Conditions

Cardiovascular Diseases Periodontal Diseases

Keywords

Periodontitis, GCF

Outcome Measures

Primary Outcomes (2)

miR-7a-5p, miR-21-5p, miR-100-5p, miR-125b-5p and miR-200b-5p changes
Changes in miR-7a-5p, miR-21-5p, miR-100-5p, miR-125b-5p and miR-200b-5p after treatment
1-year
Clinical attachment level reduction
evaluation of millimeters reduction of clinical attachment level (CAL) after periodontal therapy
1-year

Study Arms (2)

Q-SRP

Evaluation of changes of gingival crevicular fluid miRNA

Other: changes of gingival crevicular fluid miRNA

FM-SRP

Evaluation of changes of gingival crevicular fluid miRNA

Other: changes of gingival crevicular fluid miRNA

Interventions

changes of gingival crevicular fluid miRNAOther

Evaluation of changes of gingival crevicular fluid miRNA after periodontal treatment

FM-SRPQ-SRP

Registry-reported names are shown in full. Names without a link have not yet been matched to a Syfrah profile.

Eligibility Criteria

Age18 Years - 70 Years

Sexall

Healthy VolunteersYes

Age GroupsAdult (18-64), Older Adult (65+)

Sampling MethodNon-Probability Sample

Study Population

Q-SRP (no. 44 patients), FM-SRP (no. 45 patients)

You may qualify if:

Presence of at least 15 teeth

Sponsors & Collaborators

University of Catania
Otherlead

Study Sites (1)

University of Catania

Catania, CT, 95124, Italy

MeSH Terms

Conditions

Cardiovascular DiseasesPeriodontal DiseasesPeriodontitis

Condition Hierarchy (Ancestors)

Mouth DiseasesStomatognathic Diseases

Study Officials

Gaetano Isola
Università degli Studi di Catania
PRINCIPAL INVESTIGATOR

Enrollment

89 participants (actual enrollment reported by the registry).

Study Design

Study Type: observational
Observational Model: CASE CONTROL
Time Perspective: CROSS SECTIONAL
Sponsor Type: OTHER
Responsible Party: PRINCIPAL INVESTIGATOR
PI Title: Researcher

Study Record Dates

First Submitted

February 8, 2022

First Posted

March 11, 2022

Study Start

March 14, 2022

Actual (reported)

Connecting Periodontal and Coronary Artery Disease Via the Inflammatory State of the Body

Withdrawn

NCT00093236

Impact of Gum Infection on Heart Disease

Not ApplicableCompleted

NCT05720481

Impact of Periodontal Treatment on Growth Differentiation Factor-15 Levels

Not ApplicableCompleted

NCT06354972

Impact of SASP in the GCF on the Outcomes of Periodontal Regeneration

Completed

NCT05263622

Guided Biofilm Therapy for Periodontal Patients.

Not ApplicableCompleted

NCT05254288

In-office and Domiciliary Use of a New Ozonized Gel for the Management of Periodontal Disease

Not ApplicableCompleted

CP with a minimum of 40% of sites with a clinical attachment level (CAL)

≥2mm and probing depth (PD) ≥4mm;

Presence of at least ≥2 mm of crestal alveolar bone loss verified on digital periapical radiographs

Presence of ≥40% sites with bleeding on probing (BOP)

You may not qualify if:

Intake of contraceptives
Intake of immunosuppressive or anti-inflammatory drugs throughout the last three months prior to the study
Status of pregnancy or lactation
Previous history of excessive drinking
Allergy to local anaesthetic
Intake of drugs that may potentially determine gingival hyperplasia such as Hydantoin, Nifedipine, Cyclosporin A or similar drugs.

Contact the study team to confirm eligibility.

Primary Completion

November 15, 2022

Actual (reported)

Study Completion

November 20, 2022

Actual (reported)

Last Updated

October 16, 2026

Record last verified: 2026-10

Source record

Download the complete ClinicalTrials.gov record imported by Syfrah, including fields not shown in this page. The registry may contain a newer revision.

Source: ClinicalTrials.gov.

JSON downloads include source attribution and retrieval details alongside the unchanged original record or the separately normalized values.

Registry identifier: NCT05275127
Data provider: ClinicalTrials.gov
Source updated: 2026-10-16
Normalization version: ctgov-legacy-1

Open registry record

Source retrieved: 2026-10-25 22:31:34 UTC

Locations

IT(1)

Brief Summary

Registry Overview

Trial Relationships

Related Scientific Literature

Study Timeline

First Submitted

First Posted

Study Start

Primary Completion

Study Completion

Conditions

Keywords

Outcome Measures

Primary Outcomes (2)

Study Arms (2)

Q-SRP

FM-SRP

Interventions

Eligibility Criteria

You may qualify if:

Sponsors & Collaborators

Study Sites (1)

MeSH Terms

Conditions

Condition Hierarchy (Ancestors)

Study Officials

Enrollment

Study Design

Study Record Dates

You may not qualify if:

Source record

Locations