NCT05575739|Unknown
Evaluation of the Relationship Between Oxidative Stress and Human Reproduction
OxidStressHR
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OxidStressHR
Sponsor study identifier
observational
80
1 country
1
Study Start
February 14, 2021
Actual (reported)Primary Completion
December 31, 2022
Estimated (date passed)This estimate has passed. The registry has not confirmed an actual date for this milestone.
Study Completion
February 14, 2023
Estimated (date passed)This estimate has passed. The registry has not confirmed an actual date for this milestone.
The aim of the study is to investigate the role of oxidative stress in female infertility and the relationship between the stress as it is illustrated by questionnaires, serum markers, follicular fluid markers, and ovarian response in assisted reproduction.
Registry-reported information. Elapsed time and enrollment totals alone do not measure study progress or recruitment pace.
February 14, 2023
Estimated (date passed)This estimate has passed. The registry has not confirmed an actual date for this milestone.
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Some registry-reported names shown below are not yet linked in this graph.
Dates and qualifiers reported by the registry. Estimated dates do not confirm that a milestone has occurred.
February 14, 2021
Actual (reported)September 16, 2022
Actual (reported)October 12, 2022
Actual (reported)December 31, 2022
Estimated (date passed)This estimate has passed. The registry has not confirmed an actual date for this milestone.
February 14, 2023
Estimated (date passed)This estimate has passed. The registry has not confirmed an actual date for this milestone.
Follicular fluid and serum: malondialdehide, glutathione disulphate, total antioxidant capacity, superoxide dismutase and carbonated proteins on the day of ovarian puncture in in vitro fertilisation procedures.
The primary outcome of the study is to establish the correlation between the oxidative stress markers and the ovarian response and the IVF(in vitro fertilization) success (number of oocytes retrieved, mature oocytes, fertilization rate, blastulation rate).
7 days (from ovulation trigger to day 5 embryo, meaning blastocyst)
Correlation between the levels of oxidative stress markers (malondialdehide, glutathione disulphate, total antioxidant capacity, superoxide dismutase and carbonated proteins) and the cause of infertility.
The values of malondialdehide, glutathione disulphate, total antioxidant capacity, superoxide dismutase and carbonated proteins in patients going trough an IVF procedure and the way the are associated with the cause of infertility. If the values differ between the two groups and if they impact the outcome of the IVF procedure (number of oocytes retrieved, mature oocytes, fertilization rate, blastulation rate) in either group.
7 days (from ovulation trigger to day 5 embryo, meaning blastocyst)
Couples that have just the male factor as cause of infertility
diminished ovarian reserve polycystic ovarian syndrome unexplained infertility tubal factor
Follicular fluid and serum were obtained within 1 hour of oocyte recovery. Considerable care was taken to pool follicular fluid uncontaminated with blood. The samples were processed by centrifuge and 1-mL aliquots stored ar -80ºC until assay. Malondialdehide, glutathione disulphate, total antioxidant capacity, superoxide dismutase and carbonylated proteins were measured from follicular fluid and plasma according to manufacturer's protocol. This assay has been described as highly sensitive. Data were expressed as millimoles per liter from the reference curve.
Registry-reported names are shown in full. Names without a link have not yet been matched to a Syfrah profile.
Population is homogeneous. Study group are females that struggle with infertility.
Calla Ivf
Oradea, Bihor County, Romania
Anca Huniadi
CALLA IVF
First Submitted
September 16, 2022
First Posted
October 12, 2022
Study Start
February 14, 2021
Actual (reported)Primary Completion
December 31, 2022
Estimated (date passed)EValuation of the Antioxidant and Anti-inflammatory Capacity of Nutraceutical IMMU·SYSTEM Food Supplement (EVAANIS)
Antioxidant-rich Diet and Oxidative Stress in Healthy Preschoolers
Questionnaire of psychological evaluation of perception of the day to day level of stress and the association with the levels of oxidative stress in the day of ovarian puncture.
1-2 hours
Correlation between maternal age and ovarian reserve and the values of oxidative stress markers (malondialdehide, glutathione disulphate, total antioxidant capacity, superoxide dismutase and carbonated proteins) in the ovarian stimulation outcome.
18 months
Correlation between HOMA-IR value (fasting insulin (microU/L) x fasting glucose (nmol/L)/22.5), insulino-resistance and the body mass index, values of oxidative stress markers and ovarian stimulation outcome.
Day 1 of ovarian stimulation
Contact the study team to confirm eligibility.
This estimate has passed. The registry has not confirmed an actual date for this milestone.
Study Completion
February 14, 2023
Estimated (date passed)This estimate has passed. The registry has not confirmed an actual date for this milestone.
Last Updated
October 12, 2022
Record last verified: 2022-10
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Source: ClinicalTrials.gov.
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