NCT04375137

Completed

Correlation Between Oxidative Stress Status and COVID-19 Sev...

Shahid Beheshti University of Medical Sciences Source

Compare

Other study identifiers

Sponsor study identifier

SBMU.12543

Study Type

observational

Actual enrollment (reported)

90

Locations

1 country

Sites

1

Timeline

Study Start

April 20, 2020

Actual (reported)

Primary Completion

April 1, 2022

Actual (reported)

Study Completion

May 30, 2022

Actual (reported)

Brief Summary

During the new COVID-19 pandemic physicians all over the world have faced different challenges .Oxidative stress is a probable cause of multi organ failure in this setting which never has been evaluated in COVID-19 infection to the best of knowledge.Present study aimed to evaluate oxidative stress marker and redox system status in different COVID-19 patients regarding the severity of involvement.

Registry Overview

Registry-reported information. Elapsed time and enrollment totals alone do not measure study progress or recruitment pace.

Recruitment status: completed
Actual enrollment (reported): 90 participants
Study completion date: May 30, 2022
Actual (reported)
Listed locations: 1 countries · 1 sites

Trial Relationships

Click on a node to explore related trials.

Some registry-reported names shown below are not yet linked in this graph.

Study Timeline

Dates and qualifiers reported by the registry. Estimated dates do not confirm that a milestone has occurred.

Study Start
April 20, 2020
Actual (reported)
First Submitted
May 3, 2020
Actual (reported)
First Posted
May 5, 2020
Actual (reported)
Primary Completion
April 1, 2022
Actual (reported)
Study Completion
May 30, 2022
Actual (reported)

Last Updated: July 18, 2023
Status Verified: July 2023
Last Update Submitted: July 15, 2023

Conditions

Oxidative Stress

Outcome Measures

Primary Outcomes (1)

MDA concentration
MDA x 2 ULN in severe COVID
2 weeks

Secondary Outcomes (2)

Biopterin concentration
2 weeks
Neopterin rate of increase
2 weeks

Study Arms (3)

Severe COVID

patients with positive PCR or compatible CT admitted in ICU or intubated

Diagnostic Test: Oxidative Stress ELISA Kit

Non-severe COVID-19

patients with positive PCR or compatible CT admitted in ward without hypoxia

Diagnostic Test: Oxidative Stress ELISA Kit

Healthy Controls

Healthy controls with negative IgM/IgG for COVID-19

Diagnostic Test: Oxidative Stress ELISA Kit

Interventions

Oxidative Stress ELISA KitDiagnostic test

Checking oxidative stress markers and redox system status

Healthy ControlsNon-severe COVID-19Severe COVID

Registry-reported names are shown in full. Names without a link have not yet been matched to a Syfrah profile.

Eligibility Criteria

Age18 Years+

Sexall

Healthy VolunteersYes

Age GroupsAdult (18-64), Older Adult (65+)

Sampling MethodNon-Probability Sample

Study Population

Severe COVID:Hypoxic intubated Non-severe COVID: non-hypoxic in ward Healthy Controls

You may qualify if:

more than 18 years old

Sponsors & Collaborators

Shahid Beheshti University of Medical Sciences
Otherlead

Study Sites (1)

Nooshin Dalili

Tehran, Iran

Study Officials

Dalili
SBMU
PRINCIPAL INVESTIGATOR

Enrollment

90 participants (actual enrollment reported by the registry).

Study Design

Study Type: observational
Observational Model: CASE CONTROL
Time Perspective: CROSS SECTIONAL
Sponsor Type: OTHER
Responsible Party: PRINCIPAL INVESTIGATOR
PI Title: Principal Investigator

Study Record Dates

First Submitted

May 3, 2020

First Posted

May 5, 2020

Study Start

April 20, 2020

Actual (reported)

NCT05149716

Taurine as a Possible Anti-aging Therapy?

Not ApplicableCompleted

NCT05673395

Drinking Effect of Electrolyzed Alkaline Reduced Water on Oxidative Stress and Fatigue After Intense Exercise

Not ApplicableCompleted

NCT02577692

Inspired Oxygen on Oxidative Stress and Breath Volatile Organic Compound Composition in Healthy Volunteers

Not ApplicableUnknown

NCT05756842

Honey Consumption, Oxidative Stress and Health

Not ApplicableUnknown

NCT03798821

The Antioxidant Efficacy of a Product Probiotic in Research

Not ApplicableCompleted

NCT05232370

The Effect of Enalapril, Losartan or Not Antihypertensive on the Oxidative Status in Renal Transplant Recipients

Phase 2Completed

positive RT-PCR COVID-19

compatible lung CT with COVID-19

You may not qualify if:

not signing informed consent
using antioxidants
using statins

Contact the study team to confirm eligibility.

Primary Completion

April 1, 2022

Actual (reported)

Study Completion

May 30, 2022

Actual (reported)

Last Updated

July 18, 2023

Record last verified: 2023-07

Data Sharing

IPD Sharing: Will not share

Source record

Download the complete ClinicalTrials.gov record imported by Syfrah, including fields not shown in this page. The registry may contain a newer revision.

Source: ClinicalTrials.gov.

JSON downloads include source attribution and retrieval details alongside the unchanged original record or the separately normalized values.

Registry identifier: NCT04375137
Data provider: ClinicalTrials.gov
Source updated: 2023-07-18
Normalization version: ctgov-legacy-1

Open registry record

Source retrieved: 2026-10-25 22:21:47 UTC

Locations

IR(1)

Brief Summary

Registry Overview

Trial Relationships

Related Scientific Literature

Study Timeline

Study Start

First Submitted

First Posted

Primary Completion

Study Completion

Conditions

Outcome Measures

Primary Outcomes (1)

Secondary Outcomes (2)

Study Arms (3)

Severe COVID

Non-severe COVID-19

Healthy Controls

Interventions

Eligibility Criteria

You may qualify if:

Sponsors & Collaborators

Study Sites (1)

Study Officials

Enrollment

Study Design

Study Record Dates

You may not qualify if:

Data Sharing

Source record

Locations