Role Of Serum Adiponectin In The Ealy Detection Of Renal Impairment In Patients With Non Alcoholic Fatty Liver Disease

NCT05556135 | Unknown

• 1 other identifier: Serum Adiponectin in NAFLD
• Study Type: observational
• Target: 90
• Locations: 0 countries
• Sites: N/A

Brief Summary

Early detection of renal impairment in patients with Non-alcoholic fatty liver disease and its correlation with serum Adiponectin level.

Conditions

Renal Impairment

Outcome Measures

Primary Outcomes (1)

• Correlate serum Adiponectin level with renal impairment in non-alcoholic fatty liver disease.

  Correlate serum Adiponectin level with renal impairment in non-alcoholic fatty liver disease. /

  baseline

Study Arms (2)

group1

NAFLD patients

Diagnostic Test: level of serun adiponectin

group 2

non NAFLD patients

Diagnostic Test: level of serun adiponectin

Interventions

level of serun adiponectin DIAGNOSTIC_TEST

estimation of level of serum adiponectin in NAFLD for early detection of renal impairement

group 2; group1

Eligibility Criteria

• Age: 18 Years - 60 Years
• Sex: all
• Age Groups: Adult (18-64)
• Sampling Method: Non-Probability Sample

Study Population

All patients who fulfil inclusion and exclusion criteria then directed to nephrology unit to do other full investigations ,will be included in this study . 1)Full history and clinical examination .2) Investigation : * All patients will be investigated for detection of renal impairment by : 1)microalbuminurea. * 2)Urine analyses. * 3)Kidney function tests. * 4)calculate GFR. * 5)Complete blood count . * And also to detect the degree of liver affection by: * 1)liver function tests . * 2)abdominal ultrasound to grade fatty liver \& determine echogenicity of kidney . * 3)Non-invasive blood test to detect degree of hepatic steatosis ( FIB-4 , APRI, fibrosis score ). 4)fibroscane . * Detection of serum Adiponectin by ELISA technique using (EIA-3418) KIT, DRG international inc., USA \*Investigations to control risk factors of Non-alcoholic fatty liver disease: -Calculate Body Mass Index (BMI). - Measuring the fasting blood sugar and HbA1C level in all subjects. -Lipid Profile.

You may qualify if:

• Patients with fatty liver aged from 18 to 60 yrs either diabetic or not .
• Patient with normal echogenic kidney in ultrasound and eGFR more than 60 mL/min/1.73m2.
• The Control group are completely healthy subjects without any systemic or liver and kidney affection

You may not qualify if:

• )Patients less than 18 yrs \& more than 60 yrs 2)All patients having any other causes of renal and hepatic disease rather than Diabetes and having any other systemic problem.

Sponsors & Collaborators

• Assiut University: lead

Related Publications (2)

• Montesano R, Orci L, Vassalli P. In vitro rapid organization of endothelial cells into capillary-like networks is promoted by collagen matrices. J Cell Biol. 1983 Nov;97(5 Pt 1):1648-52. doi: 10.1083/jcb.97.5.1648.

  PMID: 6630296 BACKGROUND

• Stefan N, Stumvoll M. Adiponectin--its role in metabolism and beyond. Horm Metab Res. 2002 Sep;34(9):469-74. doi: 10.1055/s-2002-34785.

  PMID: 12384822 BACKGROUND

MeSH Terms

Conditions

Renal Insufficiency

Condition Hierarchy (Ancestors)

Kidney Diseases; Urologic Diseases; Female Urogenital Diseases; Female Urogenital Diseases and Pregnancy Complications; Urogenital Diseases; Male Urogenital Diseases

Study Officials

• mohamed hassan, MD

  master

  STUDY DIRECTOR

Central Study Contacts

Mustafa Abdelrafie, master

CONTACT

01010303737; mustafabadary@yahoo.com

mohamed elyamany, MD

CONTACT

01002228914; elyamany50@yahoo.com

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Target Duration: 1 Year
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: mohamed elyamany

Study Record Dates

• First Submitted: September 23, 2022
• First Posted: September 27, 2022
• Study Start: October 1, 2022
• Primary Completion: October 1, 2023
• Study Completion: October 1, 2023
• Last Updated: September 27, 2022

Record last verified: 2022-09