Resistance Training, Detraining, and Retraining Study 2022

NCT05553769 | Completed

• 1 other identifier: TraDeRe2022
• Study Type: interventional
• Target: 42
• Locations: 1 country
• Sites: 1

Brief Summary

The research project is aiming to examine the muscular adaptations to resistance training (RT), detraining (DT) and repeated RT (i.e. retraining). The research project will also examine differences in muscular adaptations between 20 weeks of continuous RT and 20 weeks of intermittent RT including a 10-week DT period in the middle of the training intervention. This is randomized controlled trial in which the research participants will be randomized into discontinuous and continuous groups (both n=\~20). Both will be doing a 2-3-week familiarization and control period at the start. Then in the former there will be an initial strength training period (10-wks), a DT period (10-wks), and a second strength training (retraining) period (10-wks). The second group includes a 10-wk non-training control period (10-wks) followed by a RT period (20-wks). Participants will be young, healthy men and women (age 18-35, which 50% are females) with no systematic RT experience during the last 6 months. Measurements will be completed before and after each study period. Body composition will be measured via bioelectrical impedance analysis (BIA) and 3D body scans. Dynamic leg press and elbow flexion one repetition-maximum (1RM) will be used to test maximal strength. Anaerobic performance and strength endurance will be tested in elbow flexion and dynamic leg press using RM tests. Vastus lateralis (VL) and biceps brachii muscle cross-sectional area (CSA) will be assessed via ultrasound. Muscle biopsies of the VL muscle will be obtained to assess changes in muscle fiber morphology and factors regulating and associated with the hypertrophic processes and metabolism. Blood samples will be collected to analyze changes in metabolism and physiology. A rating of perceived exertion (RPE) during training will be collected after every exercise to ensure proper training intensity. Finally, nutrition and habitual physical activity will be assessed with 4-day diet diaries and physical activity questionnaires before the intervention and during each 10-week period.

Conditions

Exercise Training; Skeletal Muscle; Skeletal Muscle Atrophy

Outcome Measures

Primary Outcomes (1)

• Change in upper and lower limb maximal strength after 10-week RT

  Maximal muscle strength will be assessed via one repetition maximum (1RM) tests of both the leg press and barbell biceps curl exercises according to the NSCA's guidelines.

  week -2, week 0, week 10

Secondary Outcomes (7)

• Change in muscular performance after 20-week continuous RT period and two 10-week RT periods separated by a 10-week DT period

  week -2, week 0, week 10, week 20, week 30

• Change in upper and lower limb muscle CSA after 10-week RT period

  week -2, week 0, week 10

• Change in upper and lower limb muscle CSA after 20-week continuous RT period and two 10-week RT periods separated by a 10-week DT period

  week 0, week 10, week 20, week 30

• Changes in muscle fiber size during the intervention period

  week 0, week 10, week 20, week 30

• Change in lean mass during the intervention period

  week -2, week 0, week 10, week 20, week 30

Other Outcomes (3)

• Changes in muscle fiber morphology and metabolism during the intervention period

  week 0, week 10, week 20, week 30

• Changes in metabolomics during the intervention period

  week 0, week 10, week 20, week 30

• Changes in proteomics during the intervention period

  week 0, week 10, week 20, week 30

Study Arms (2)

10 week training, 10 week detraining, 10 week retraining

EXPERIMENTAL

Participants (healthy untrained men and women, age 18-40) will conduct 10-week RT intervention and a 10-week DT period and the exact same 10-week RT intervention again. RT consists of two training sessions per week of total body workouts.

Other: Resistance training, detraining, retraining

10 week non-training, 20 week continuous training

EXPERIMENTAL

Participants (healthy untrained men and women, age 18-40) start with a 10-week non-training period and then continues with a 20-week RT intervention. RT consists of two training sessions per week of total body workouts.

Other: Resistance training, detraining, retraining

Interventions

Resistance training, detraining, retraining OTHER

Participants (healthy untrained men and women, age 18-40) start with a 3-week familiarization and baseline measurement period. After that, they are randomized to two intervention groups, where other group will conduct 10-week RT intervention and a 10-week DT period and again the exact same 10-week RT intervention again whereas the other group start with a 10-week non-training period and then continues with a 20-week RT intervention. RT consists of two training sessions per week of total body workouts. Same measurements are conducted for both groups with the same time intervals.

10 week non-training, 20 week continuous training; 10 week training, 10 week detraining, 10 week retraining

Eligibility Criteria

• Age: 18 Years - 40 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)

You may qualify if:

• No regular resistance training history
• BMI within range 18.5-30 kg/m2
• Participants must be 18-40 years old
• No history in systematic endurance-type training (\> 2 endurance exercise sessions lasting \> 30 minutes per week for the last six months)
• non-smoker
• not currently consuming any anti-inflammatory drug(s)

You may not qualify if:

• history of medication that could affect exercise responses
• use of nutritional supplements aside from those that are protein- or carbohydrate-based (ex. creatine) or basic minerals, vitamins, or fish oil products
• any acute or chronic illness affecting cardiovascular, respiratory, musculoskeletal and/or endocrine function
• any other condition that may limit the ability to perform resistance training and testing (ex. uncontrolled hypertension, diabetes, arthritic conditions, neuromuscular complications)

Sponsors & Collaborators

• University of Jyvaskyla: lead

Study Sites (1)

University of Jyväkylä

Jyväskylä, Central Finland, 40014, Finland

Location

Related Publications (1)

• Halonen EJ, Gabriel I, Kelahaara MM, Ahtiainen JP, Hulmi JJ. Does Taking a Break Matter-Adaptations in Muscle Strength and Size Between Continuous and Periodic Resistance Training. Scand J Med Sci Sports. 2024 Oct;34(10):e14739. doi: 10.1111/sms.14739.

  PMID: 39364857 DERIVED

MeSH Terms

Conditions

Muscular Atrophy

Interventions

Resistance Training

Condition Hierarchy (Ancestors)

Neuromuscular Manifestations; Neurologic Manifestations; Nervous System Diseases; Atrophy; Pathological Conditions, Anatomical; Pathological Conditions, Signs and Symptoms; Signs and Symptoms

Intervention Hierarchy (Ancestors)

Exercise Therapy; Rehabilitation; Aftercare; Continuity of Patient Care; Patient Care; Therapeutics; Physical Therapy Modalities; Physical Conditioning, Human; Exercise; Motor Activity; Movement; Musculoskeletal Physiological Phenomena; Musculoskeletal and Neural Physiological Phenomena

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: DOUBLE
• Who Masked: INVESTIGATOR, OUTCOMES ASSESSOR
• Purpose: BASIC SCIENCE
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Model Details: Participants (healthy untrained men and women, age 18-40) start with a 3-week familiarization and baseline measurement period. After that, they are randomized to two intervention groups, where other group will conduct 10-week RT intervention and a 10-week DT period and again the exact same 10-week RT intervention again whereas the other group start with a 10-week non-training period and then continues with a 20-week RT intervention. RT consists of two training sessions per week of total body workouts. Same measurements are conducted for both groups with the same time intervals.

Study Record Dates

• First Submitted: March 2, 2022
• First Posted: September 23, 2022
• Study Start: March 1, 2022
• Primary Completion: December 31, 2022
• Study Completion: December 31, 2022
• Last Updated: April 10, 2024

Record last verified: 2024-04

Data Sharing

• IPD Sharing: Will not share

Locations

FI (1)