Discriminant Ability of the Shock Index, Modified Shock Index, and Reverse Shock Index Multiplied by the Glasgow Coma Scale on Mortality in Adult Trauma Patients: A PATOS Study

NCT05549986 | Completed DMC

• 1 other identifier: 21MMHIS389e
• Study Type: observational
• Target: 105,641
• Locations: 0 countries
• Sites: N/A

Brief Summary

We evaluated a cohort of adult trauma patients transported to emergency departments. The first vital signs were used to calculate the SI, MSI, and rSIG. The areas under the receiver operating characteristic curves (AUROCs) and test results were used to compare the discriminant performance of the indices on short-term mortality and poor functional outcome. A subgroup analysis of geriatric patients, traumatic brain injury, penetrating injury, and non-penetrating injury was performed.

Conditions

Trauma; Shock, Traumatic; Morality

Keywords

Shock index(SI); Modified Shock Index (MSI); Reverse Shock Index Multiplied by the Glasgow Coma Scale (rSIG); Mortality; Pan-Asian Trauma Outcomes Study (PATOS)

Outcome Measures

Primary Outcomes (1)

• Discriminant power of SI, MSI, and rSIG on short-term mortality for adult traumatic patients

  AUROC in associated with short-term mortality with SI, MSI, rSIG

  30 days

Secondary Outcomes (1)

• Discriminant power of SI, MSI, and rSIG on functional outcome for adult traumatic patients

  We defined no symptoms, no significant disability, slight disability, and moderate disability (MRS 0-3) as favorable functional outcomes and moderately severe disability, severe disability, and death (MRS 4-6) as poor functional outcomes

Study Arms (2)

Mortality group

Patients encountered in-hospital mortality or 30-day mortality

Other: Observational

Survival group

Patients did not encounter in-hospital mortality or 30-day mortality

Other: Observational

Interventions

Observational OTHER

Observational

Mortality group; Survival group

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

This study included adult patients (≥18 years) EMS-transported from January 2016 to December 2020. Patients with missing entries of age, sex, triage, SBP, DBP, HR, or GCS were excluded. Entries with missing records of in-hospital mortality or 30-day mortality were excluded from the short-term mortality cohort analyses. Patients without a Modified Rankin Scale (MRS) record at discharge were excluded from the functional outcome cohort analyses.

You may qualify if:

• Adult patients (≥18 years) EMS-transported from January 2016 to December 2020

You may not qualify if:

• Patients with missing entries of age, sex, triage, SBP, DBP, HR, or GCS were excluded.
• Entries with missing records of in-hospital mortality or 30-day mortality were excluded from the short-term mortality cohort analyses.
• Patients without a Modified Rankin Scale (MRS) record at discharge were excluded from the functional outcome cohort analyses.

Sponsors & Collaborators

• Mackay Memorial Hospital: lead

Related Publications (1)

• Chen TH, Wu MY, Do Shin S, Jamaluddin SF, Son DN, Hong KJ, Jen-Tang S, Tanaka H, Hsiao CH, Hsieh SL, Chien DK, Tsai W, Chang WH, Chiang WC; PATOS Clinical Research Network. Discriminant ability of the shock index, modified shock index, and reverse shock index multiplied by the Glasgow coma scale on mortality in adult trauma patients: a PATOS retrospective cohort study. Int J Surg. 2023 May 1;109(5):1231-1238. doi: 10.1097/JS9.0000000000000287.

  PMID: 37222717 DERIVED

MeSH Terms

Conditions

Wounds and Injuries; Shock, Traumatic

Interventions

Watchful Waiting

Condition Hierarchy (Ancestors)

Shock; Pathologic Processes; Pathological Conditions, Signs and Symptoms

Intervention Hierarchy (Ancestors)

Outcome Assessment, Health Care; Outcome and Process Assessment, Health Care; Quality of Health Care; Health Services Administration

Study Officials

• Tse-Hao Chen, M.D.

  Mackay Memorial Hospital

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: RETROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Principal Investigator

Study Record Dates

• First Submitted: August 29, 2022
• First Posted: September 22, 2022
• Study Start: January 1, 2016
• Primary Completion: December 31, 2020
• Study Completion: December 31, 2020
• Last Updated: September 22, 2022

Record last verified: 2022-09

Data Sharing

• IPD Sharing: Will not share