The Validation and Development of Termination-of-Resuscitation (TOR) Rules in OHCA Patients in Asia Countries

NCT05545176 | Recruiting DMC

• 1 other identifier: 202206030RINC
• Study Type: observational
• Target: 140,000
• Locations: 1 country
• Sites: 1

Brief Summary

Objectives/Hypotheses

1. 1.Prehospital termination-of-resuscitation (TOR) rules were developed in North American and European sites. Whether they remained valid in different geographic, ethnic, and cultural background areas is still under debate.
2. 2.Differences in characteristics of out-of-hospital cardiac arrests (OHCAs) and configurations of emergency medical service (EMS) between the Western and Asian countries, including relatively lower rate of presenting shockable rhythm (i.e. ventricular fibrillation / ventricular tachycardia; VF/VT), lower rates of bystander CPR, less advanced life support (ALS) implementation, and less public access defibrillators, might create potential threats to the prediction accuracy of TOR rules.
3. 3.We aim to conduct a study to validate the performance of ever published TOR rules in Asian OHCA population, including non-traumatic, traumatic, and pediatric OHCA patients. Furthermore, assess the possible variables that may impact the performance of TOR rules.
4. 4.We also aim to develop new TOR rules based on PAROS registry for Asia population, focusing on non-traumatic, traumatic, and pediatric OHCA patients, respectively.

Conditions

Out-Of-Hospital Cardiac Arrest

Keywords

Out-Of-Hospital Cardiac Arrest; OHCA

Outcome Measures

Primary Outcomes (1)

• survival to hospital discharge

  survival to 30-day hospitalisation

  survival to 30-day hospitalisation

Secondary Outcomes (1)

• Cerebral Performance Categories Scale (CPC)

  CPC within 30-day hospitalisation

Study Arms (1)

out of hospital cardiac arrest patients in Asia countries

Other: termination of resuscitation rules

Interventions

termination of resuscitation rules OTHER

Use retrospective data to analyze the accuracy termination of resuscitation rules and further develope a termination of resuscitation rule.

out of hospital cardiac arrest patients in Asia countries

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Probability Sample

Study Population

The study population included adults, OHCA patients since1 January 2007, identified from the PAROS registry. The PAROS data encompass 13 countries. The exclusion criteria include: (1) age \<18 years, (2) non-EMS transport to the emergency department, (3) obvious signs of death (e.g. decapitation, rigor mortis, lividity, and decapitation) or having do-not-resuscitate (DNR) orders, and (4) missing data despite meeting the inclusion criteria.

You may qualify if:

• out of hospital cardiac arrest (OHCA) patients

You may not qualify if:

• age \<18 years
• non-EMS transport to the emergency department
• obvious signs of death (e.g. decapitation, rigor mortis, lividity, and decapitation) or having do-not-resuscitate (DNR) orders

Sponsors & Collaborators

• Singapore Clinical Research Institute: collaborator
• National Taiwan University Hospital: lead

Study Sites (1)

National Taiwan University

Taipei, Taiwan

RECRUITING

MeSH Terms

Conditions

Out-of-Hospital Cardiac Arrest

Condition Hierarchy (Ancestors)

Heart Arrest; Heart Diseases; Cardiovascular Diseases

Study Officials

• Shu-Hsien Hsu, MPH

  National Taiwan University

  PRINCIPAL INVESTIGATOR

Central Study Contacts

Shu-Hsien Hsu, MPH

CONTACT

pedroe929@gmail.com

Study Design

• Study Type: observational
• Observational Model: OTHER
• Time Perspective: OTHER
• Target Duration: 20 Years
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: September 14, 2022
• First Posted: September 19, 2022
• Study Start: January 1, 2007
• Primary Completion (Estimated): June 1, 2032
• Study Completion (Estimated): December 31, 2032
• Last Updated: February 25, 2026

Record last verified: 2024-12

Data Sharing

• IPD Sharing: Will share
• Shared Documents: CSR
• Time Frame: 30 years
• Access Criteria: PAROS study members

Locations

TW (1)