NCT05541133

Completed

Effect of Acute Exercise on Exosome Associated Biomarkers

Mayo Clinic Source

Other study identifiers

Sponsor study identifier

22-000001

Study Type

observational

Actual enrollment (reported)

12

Locations

1 country

Sites

1

Timeline

Study Start

June 21, 2022

Actual (reported)

Primary Completion

July 9, 2022

Actual (reported)

Study Completion

December 31, 2024

Actual (reported)

Brief Summary

This research study is being done to understand the underlying mechanism by which exercise affects the body on the cellular level, in an acute aerobic endurance setting. This may help to better understand the overall benefits of endurance exercise.

Registry Overview

Registry-reported information. Elapsed time and enrollment totals alone do not measure study progress or recruitment pace.

Recruitment status: completed
Actual enrollment (reported): 12 participants
Study completion date: December 31, 2024
Actual (reported)
Listed locations: 1 countries · 1 sites

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Dates and qualifiers reported by the registry. Estimated dates do not confirm that a milestone has occurred.

Study Start
June 21, 2022
Actual (reported)
Primary Completion
July 9, 2022
Actual (reported)
First Submitted
September 12, 2022
Actual (reported)
First Posted
September 15, 2022
Actual (reported)
Study Completion
December 31, 2024
Actual (reported)

Last Updated: April 9, 2025
Status Verified: April 2025
Last Update Submitted: April 7, 2025

Conditions

Healthy

Outcome Measures

Primary Outcomes (1)

List of biomarkers
Exosome proteomes and MiRNA from blood samples
Baseline

Eligibility Criteria

Age18 Years - 45 Years

Sexall

Healthy VolunteersYes

Age GroupsAdult (18-64)

Sampling MethodNon-Probability Sample

Study Population

Generally healthy individuals around the Rochester MN area.

You may qualify if:

Ages: 18 to 45 years

You may not qualify if:

Sponsors & Collaborators

Mayo Clinic
Otherlead

Study Sites (1)

Mayo Clinic in Rochester

Rochester, Minnesota, 55905, United States

Biospecimen

Retention: SAMPLES WITHOUT DNA

Blood samples collected before, during, and after acute exercise.

Study Officials

K. Sreekumaran Nair, MD, PhD
Mayo Clinic
PRINCIPAL INVESTIGATOR

Enrollment

12 participants (actual enrollment reported by the registry).

Study Design

Study Type: observational
Observational Model: COHORT
Time Perspective: PROSPECTIVE
Sponsor Type: OTHER
Responsible Party: PRINCIPAL INVESTIGATOR
PI Title: Principal Investigator

Study Record Dates

First Submitted

September 12, 2022

First Posted

September 15, 2022

Study Start

June 21, 2022

Actual (reported)

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BMI \>32 kg/m2. Cardiovascular, metabolic (type 2 diabetes, fasting plasma glucose at or above 110 mg/dL and untreated hypo- or hyperthyroidism) or renal disease.
Orthopedic problems that would keep them from being able to perform an exercise. - --
Medications that are known to affect mitochondrial function: Corticosteroids, opiates, benzodiazepines, tricyclic antidepressants, beta-blockers, sulfonylureas, insulin, anticoagulants, barbiturates, insulin sensitizers, fibrates (PPAR gamma agonist).
Smoking.
Pregnancy.

Contact the study team to confirm eligibility.

Primary Completion

July 9, 2022

Actual (reported)

Study Completion

December 31, 2024

Actual (reported)

Last Updated

April 9, 2025

Record last verified: 2025-04

Data Sharing

IPD Sharing: Will not share

Source record

Download the complete ClinicalTrials.gov record imported by Syfrah, including fields not shown in this page. The registry may contain a newer revision.

Source: ClinicalTrials.gov.

JSON downloads include source attribution and retrieval details alongside the unchanged original record or the separately normalized values.

Registry identifier: NCT05541133
Data provider: ClinicalTrials.gov
Source updated: 2025-04-09
Normalization version: ctgov-legacy-1

Open registry record

Source retrieved: 2026-10-25 22:21:43 UTC

Locations

US(1)

Brief Summary

Registry Overview

Trial Relationships

Related Scientific Literature

Study Timeline

Study Start

Primary Completion

First Submitted

First Posted

Study Completion

Conditions

Outcome Measures

Primary Outcomes (1)

Eligibility Criteria

You may qualify if:

You may not qualify if:

Sponsors & Collaborators

Study Sites (1)

Related Links

Biospecimen

Study Officials

Enrollment

Study Design

Study Record Dates

Data Sharing

Source record

Locations